Coupling chemical mutagenesis to next generation sequencing for the identification of drug resistance mutations in Leishmania

Coupling chemical mutagenesis to next generation sequencing for the identification of drug resistance mutations in Leishmania

Here, Bhattacharya et al. chemically mutagenize Leishmania and identify genes associated with resistance to miltefosine and paromomycin by next generation sequencing. The study shows that a protein kinase (CDPK1) can mediate resistance to paromomycin by affecting translation.

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Detalles Bibliográficos
Autores principales: Arijit Bhattacharya, Philippe Leprohon, Sophia Bigot, Prasad Kottayil Padmanabhan, Angana Mukherjee, Gaétan Roy, Hélène Gingras, Anais Mestdagh, Barbara Papadopoulou, Marc Ouellette
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/31297421268e443fb05fa40f1379e120
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