Translational control of breast cancer plasticity

Protein synthesis suppression protects breast cancer cells from clinically relevant stresses like hypoxia. Here, the authors show that unique mRNA isoforms that govern stem cell-like phenotypes escape translational repression to drive tumor progression and chemoresistance.

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Autores principales:	Michael Jewer, Laura Lee, Matthew Leibovitch, Guihua Zhang, Jiahui Liu, Scott D. Findlay, Krista M. Vincent, Kristofferson Tandoc, Dylan Dieters-Castator, Daniela F. Quail, Indrani Dutta, Mackenzie Coatham, Zhihua Xu, Aakshi Puri, Bo-Jhih Guan, Maria Hatzoglou, Andrea Brumwell, James Uniacke, Christos Patsis, Antonis Koromilas, Julia Schueler, Gabrielle M. Siegers, Ivan Topisirovic, Lynne-Marie Postovit
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/312a98522c974e78ae7065a78eaa0f90
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spelling	oai:doaj.org-article:312a98522c974e78ae7065a78eaa0f902021-12-02T15:52:45ZTranslational control of breast cancer plasticity10.1038/s41467-020-16352-z2041-1723https://doaj.org/article/312a98522c974e78ae7065a78eaa0f902020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16352-zhttps://doaj.org/toc/2041-1723Protein synthesis suppression protects breast cancer cells from clinically relevant stresses like hypoxia. Here, the authors show that unique mRNA isoforms that govern stem cell-like phenotypes escape translational repression to drive tumor progression and chemoresistance.Michael JewerLaura LeeMatthew LeibovitchGuihua ZhangJiahui LiuScott D. FindlayKrista M. VincentKristofferson TandocDylan Dieters-CastatorDaniela F. QuailIndrani DuttaMackenzie CoathamZhihua XuAakshi PuriBo-Jhih GuanMaria HatzoglouAndrea BrumwellJames UniackeChristos PatsisAntonis KoromilasJulia SchuelerGabrielle M. SiegersIvan TopisirovicLynne-Marie PostovitNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Michael Jewer Laura Lee Matthew Leibovitch Guihua Zhang Jiahui Liu Scott D. Findlay Krista M. Vincent Kristofferson Tandoc Dylan Dieters-Castator Daniela F. Quail Indrani Dutta Mackenzie Coatham Zhihua Xu Aakshi Puri Bo-Jhih Guan Maria Hatzoglou Andrea Brumwell James Uniacke Christos Patsis Antonis Koromilas Julia Schueler Gabrielle M. Siegers Ivan Topisirovic Lynne-Marie Postovit Translational control of breast cancer plasticity
description	Protein synthesis suppression protects breast cancer cells from clinically relevant stresses like hypoxia. Here, the authors show that unique mRNA isoforms that govern stem cell-like phenotypes escape translational repression to drive tumor progression and chemoresistance.
format	article
author	Michael Jewer Laura Lee Matthew Leibovitch Guihua Zhang Jiahui Liu Scott D. Findlay Krista M. Vincent Kristofferson Tandoc Dylan Dieters-Castator Daniela F. Quail Indrani Dutta Mackenzie Coatham Zhihua Xu Aakshi Puri Bo-Jhih Guan Maria Hatzoglou Andrea Brumwell James Uniacke Christos Patsis Antonis Koromilas Julia Schueler Gabrielle M. Siegers Ivan Topisirovic Lynne-Marie Postovit
author_facet	Michael Jewer Laura Lee Matthew Leibovitch Guihua Zhang Jiahui Liu Scott D. Findlay Krista M. Vincent Kristofferson Tandoc Dylan Dieters-Castator Daniela F. Quail Indrani Dutta Mackenzie Coatham Zhihua Xu Aakshi Puri Bo-Jhih Guan Maria Hatzoglou Andrea Brumwell James Uniacke Christos Patsis Antonis Koromilas Julia Schueler Gabrielle M. Siegers Ivan Topisirovic Lynne-Marie Postovit
author_sort	Michael Jewer
title	Translational control of breast cancer plasticity
title_short	Translational control of breast cancer plasticity
title_full	Translational control of breast cancer plasticity
title_fullStr	Translational control of breast cancer plasticity
title_full_unstemmed	Translational control of breast cancer plasticity
title_sort	translational control of breast cancer plasticity
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/312a98522c974e78ae7065a78eaa0f90
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Translational control of breast cancer plasticity

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