Comparison between blood hemoglobin concentration determined by point-of-care device and complete blood count in adult patients with dengue.

<h4>Background</h4>Hematocrit measurement has been an indispensable tool for monitoring plasma leakage and bleeding in dengue patients. However, hematocrit measurement by automated methods is hampered by frequent venipunctures. Utility of point-of-care hemoglobin (POC-Hb) test for monito...

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Autores principales:	Kantasit Wisanuvej, Kochawan Boonyawat, Chutchaiwat Savetamornkul, Sirapong Virapongsiri, Jatupon Krongvorakul, Somnuek Sungkanuparph, Angsana Phuphuakrat
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/312c17243af040878fa0dadf5f191797
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spelling	oai:doaj.org-article:312c17243af040878fa0dadf5f1917972021-12-02T20:24:18ZComparison between blood hemoglobin concentration determined by point-of-care device and complete blood count in adult patients with dengue.1935-27271935-273510.1371/journal.pntd.0009692https://doaj.org/article/312c17243af040878fa0dadf5f1917972021-08-01T00:00:00Zhttps://doi.org/10.1371/journal.pntd.0009692https://doaj.org/toc/1935-2727https://doaj.org/toc/1935-2735<h4>Background</h4>Hematocrit measurement has been an indispensable tool for monitoring plasma leakage and bleeding in dengue patients. However, hematocrit measurement by automated methods is hampered by frequent venipunctures. Utility of point-of-care hemoglobin (POC-Hb) test for monitoring dengue patients has not been established. We evaluated the relationship between hemoglobin measured by POC-Hb testing and hematocrit measured by the automated method in adult dengue patients.<h4>Methodology and principal findings</h4>Adult dengue patients were recruited at two university hospitals in Thailand from October 2019 to December 2020. POC-Hb test was performed using capillary blood simultaneously with venipuncture to obtain whole blood for an automated complete blood count (CBC) analysis. The correlation of hemoglobin and hematocrit measurement was evaluated. A total of 44 dengue patients were enrolled. Twenty-nine patients (65.9%) were female, with a median age of 31 years (interquartile range 22-41). Of the enrolled patients, 30 (68.2%), 11 (25.0%), and 3 (6.8%) were classified as dengue without warning signs, with warning signs, and severe dengue, respectively. Seven patients (15.9%) had hemoconcentration, and five patients (11.3%) had bleeding. A total of 216 pairs of POC-Hb and CBC were evaluated. A significant positive correlation was observed between hemoglobin measured by POC-Hb testing and hematocrit measured by an automated CBC (r = 0.869, p <0.001). Bland-Altman analysis between hemoglobin measured by POC-Hb testing and an automated CBC showed a bias of -0.43 (95% limit of agreement of -1.81 and 0.95). Using the cutoff of POC-Hb ≥20% as a criteria for hemoconcentration, the sensitivity and specificity of hemoconcentration detected by POC-Hb device were 71.4% and 100.0%, respectively.<h4>Conclusions</h4>Hemoglobin measurement by POC-Hb testing has a strong correlation with hematocrit in adult patients with dengue fever. However, the sensitivity in detecting hemoconcentration is fair. The adjunct use of capillary POC-Hb testing can decrease the frequency of venipuncture. Further study in children is encouraged.Kantasit WisanuvejKochawan BoonyawatChutchaiwat SavetamornkulSirapong VirapongsiriJatupon KrongvorakulSomnuek SungkanuparphAngsana PhuphuakratPublic Library of Science (PLoS)articleArctic medicine. Tropical medicineRC955-962Public aspects of medicineRA1-1270ENPLoS Neglected Tropical Diseases, Vol 15, Iss 8, p e0009692 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
spellingShingle	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Kantasit Wisanuvej Kochawan Boonyawat Chutchaiwat Savetamornkul Sirapong Virapongsiri Jatupon Krongvorakul Somnuek Sungkanuparph Angsana Phuphuakrat Comparison between blood hemoglobin concentration determined by point-of-care device and complete blood count in adult patients with dengue.
description	<h4>Background</h4>Hematocrit measurement has been an indispensable tool for monitoring plasma leakage and bleeding in dengue patients. However, hematocrit measurement by automated methods is hampered by frequent venipunctures. Utility of point-of-care hemoglobin (POC-Hb) test for monitoring dengue patients has not been established. We evaluated the relationship between hemoglobin measured by POC-Hb testing and hematocrit measured by the automated method in adult dengue patients.<h4>Methodology and principal findings</h4>Adult dengue patients were recruited at two university hospitals in Thailand from October 2019 to December 2020. POC-Hb test was performed using capillary blood simultaneously with venipuncture to obtain whole blood for an automated complete blood count (CBC) analysis. The correlation of hemoglobin and hematocrit measurement was evaluated. A total of 44 dengue patients were enrolled. Twenty-nine patients (65.9%) were female, with a median age of 31 years (interquartile range 22-41). Of the enrolled patients, 30 (68.2%), 11 (25.0%), and 3 (6.8%) were classified as dengue without warning signs, with warning signs, and severe dengue, respectively. Seven patients (15.9%) had hemoconcentration, and five patients (11.3%) had bleeding. A total of 216 pairs of POC-Hb and CBC were evaluated. A significant positive correlation was observed between hemoglobin measured by POC-Hb testing and hematocrit measured by an automated CBC (r = 0.869, p <0.001). Bland-Altman analysis between hemoglobin measured by POC-Hb testing and an automated CBC showed a bias of -0.43 (95% limit of agreement of -1.81 and 0.95). Using the cutoff of POC-Hb ≥20% as a criteria for hemoconcentration, the sensitivity and specificity of hemoconcentration detected by POC-Hb device were 71.4% and 100.0%, respectively.<h4>Conclusions</h4>Hemoglobin measurement by POC-Hb testing has a strong correlation with hematocrit in adult patients with dengue fever. However, the sensitivity in detecting hemoconcentration is fair. The adjunct use of capillary POC-Hb testing can decrease the frequency of venipuncture. Further study in children is encouraged.
format	article
author	Kantasit Wisanuvej Kochawan Boonyawat Chutchaiwat Savetamornkul Sirapong Virapongsiri Jatupon Krongvorakul Somnuek Sungkanuparph Angsana Phuphuakrat
author_facet	Kantasit Wisanuvej Kochawan Boonyawat Chutchaiwat Savetamornkul Sirapong Virapongsiri Jatupon Krongvorakul Somnuek Sungkanuparph Angsana Phuphuakrat
author_sort	Kantasit Wisanuvej
title	Comparison between blood hemoglobin concentration determined by point-of-care device and complete blood count in adult patients with dengue.
title_short	Comparison between blood hemoglobin concentration determined by point-of-care device and complete blood count in adult patients with dengue.
title_full	Comparison between blood hemoglobin concentration determined by point-of-care device and complete blood count in adult patients with dengue.
title_fullStr	Comparison between blood hemoglobin concentration determined by point-of-care device and complete blood count in adult patients with dengue.
title_full_unstemmed	Comparison between blood hemoglobin concentration determined by point-of-care device and complete blood count in adult patients with dengue.
title_sort	comparison between blood hemoglobin concentration determined by point-of-care device and complete blood count in adult patients with dengue.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/312c17243af040878fa0dadf5f191797
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Comparison between blood hemoglobin concentration determined by point-of-care device and complete blood count in adult patients with dengue.

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