Cancer of an ectopic parathyroid gland: from diagnosis to treatment (clinical case)

The article presents a clinical case of a prolonged course of gastrointestinal ulcer disease, followed by dysphagia. During the examination, severe hyperparathyroidism was revealed, which subsequently prompted a diagnostic search for a parathyroid adenoma, which is the cause of hyperathyroidism in 8...

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Autores principales:	Arif K. Allakhverdiev, Nataliya A. Malkina, Karina K. Noskova, Vyacheslav N. Grinevich, Ilia Yu. Feidorov, Astanda F. Ketsba, Elena V. Bystrovskay, Yuliya V. Embutniex, Mariya V. Putova, Daria A. Synkova
Formato:	article
Lenguaje:	RU
Publicado:	IP Habib O.N. 2021
Materias:	parathyroid cancer parathyroid adenoma primary hyperparathyroidism osteoporosis transesophageal aspiration biopsy denosumab Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/312e48f9c1dc4f4cad250e0efa5aa207
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spelling	oai:doaj.org-article:312e48f9c1dc4f4cad250e0efa5aa2072021-11-30T17:03:34ZCancer of an ectopic parathyroid gland: from diagnosis to treatment (clinical case)1815-14341815-144210.26442/18151434.2020.4.200293https://doaj.org/article/312e48f9c1dc4f4cad250e0efa5aa2072021-02-01T00:00:00Zhttps://modernonco.orscience.ru/1815-1434/article/viewFile/61189/44275https://doaj.org/toc/1815-1434https://doaj.org/toc/1815-1442The article presents a clinical case of a prolonged course of gastrointestinal ulcer disease, followed by dysphagia. During the examination, severe hyperparathyroidism was revealed, which subsequently prompted a diagnostic search for a parathyroid adenoma, which is the cause of hyperathyroidism in 8085% of cases. With instrumental methods of research, the cause of the main complaint is dysphagia, a formation in the posterior upper mediastinum up to 5 cm, compressing the esophagus. With transoesophageal aspiration biopsy (EUS-TYPE). The cytological picture is similar to the thyroid epithelium with part of the oncocytic differentiation. In an immunological study, lavage for parathyroid hormone showed high expression. Scintigraphy with Tc-99m pertechnetate revealed the exact topic of the formation of the parathyroid gland in the posterior mediastinum an atypical location. Surgical treatment was performed in the amount of thoracoscopic removal of the mediastinal tumor. The radical nature of the surgical intervention was confirmed by laboratory. Serum PTH levels decreased significantly. Upon receipt of the morphological conclusion, reliable data on malignant damage to the parathyroid gland were obtained. Subsequent treatment of the patient consisted in the correction of severe hypercalcemia in the postoperative period by prescribing denosumab, which led to the stabilization of the patients condition.Arif K. AllakhverdievNataliya A. MalkinaKarina K. NoskovaVyacheslav N. GrinevichIlia Yu. FeidorovAstanda F. KetsbaElena V. BystrovskayYuliya V. EmbutniexMariya V. PutovaDaria A. SynkovaIP Habib O.N.articleparathyroid cancerparathyroid adenomaprimary hyperparathyroidismosteoporosistransesophageal aspiration biopsydenosumabNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282RUСовременная онкология, Vol 22, Iss 4, Pp 115-119 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	parathyroid cancer parathyroid adenoma primary hyperparathyroidism osteoporosis transesophageal aspiration biopsy denosumab Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	parathyroid cancer parathyroid adenoma primary hyperparathyroidism osteoporosis transesophageal aspiration biopsy denosumab Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Arif K. Allakhverdiev Nataliya A. Malkina Karina K. Noskova Vyacheslav N. Grinevich Ilia Yu. Feidorov Astanda F. Ketsba Elena V. Bystrovskay Yuliya V. Embutniex Mariya V. Putova Daria A. Synkova Cancer of an ectopic parathyroid gland: from diagnosis to treatment (clinical case)
description	The article presents a clinical case of a prolonged course of gastrointestinal ulcer disease, followed by dysphagia. During the examination, severe hyperparathyroidism was revealed, which subsequently prompted a diagnostic search for a parathyroid adenoma, which is the cause of hyperathyroidism in 8085% of cases. With instrumental methods of research, the cause of the main complaint is dysphagia, a formation in the posterior upper mediastinum up to 5 cm, compressing the esophagus. With transoesophageal aspiration biopsy (EUS-TYPE). The cytological picture is similar to the thyroid epithelium with part of the oncocytic differentiation. In an immunological study, lavage for parathyroid hormone showed high expression. Scintigraphy with Tc-99m pertechnetate revealed the exact topic of the formation of the parathyroid gland in the posterior mediastinum an atypical location. Surgical treatment was performed in the amount of thoracoscopic removal of the mediastinal tumor. The radical nature of the surgical intervention was confirmed by laboratory. Serum PTH levels decreased significantly. Upon receipt of the morphological conclusion, reliable data on malignant damage to the parathyroid gland were obtained. Subsequent treatment of the patient consisted in the correction of severe hypercalcemia in the postoperative period by prescribing denosumab, which led to the stabilization of the patients condition.
format	article
author	Arif K. Allakhverdiev Nataliya A. Malkina Karina K. Noskova Vyacheslav N. Grinevich Ilia Yu. Feidorov Astanda F. Ketsba Elena V. Bystrovskay Yuliya V. Embutniex Mariya V. Putova Daria A. Synkova
author_facet	Arif K. Allakhverdiev Nataliya A. Malkina Karina K. Noskova Vyacheslav N. Grinevich Ilia Yu. Feidorov Astanda F. Ketsba Elena V. Bystrovskay Yuliya V. Embutniex Mariya V. Putova Daria A. Synkova
author_sort	Arif K. Allakhverdiev
title	Cancer of an ectopic parathyroid gland: from diagnosis to treatment (clinical case)
title_short	Cancer of an ectopic parathyroid gland: from diagnosis to treatment (clinical case)
title_full	Cancer of an ectopic parathyroid gland: from diagnosis to treatment (clinical case)
title_fullStr	Cancer of an ectopic parathyroid gland: from diagnosis to treatment (clinical case)
title_full_unstemmed	Cancer of an ectopic parathyroid gland: from diagnosis to treatment (clinical case)
title_sort	cancer of an ectopic parathyroid gland: from diagnosis to treatment (clinical case)
publisher	IP Habib O.N.
publishDate	2021
url	https://doaj.org/article/312e48f9c1dc4f4cad250e0efa5aa207
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Cancer of an ectopic parathyroid gland: from diagnosis to treatment (clinical case)

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