Unconditioned stimulus revaluation to promote conditioned fear extinction in the memory reconsolidation window.

The retrieval-extinction paradigm, which disrupts the reconsolidation of fear memories in humans, is a non-invasive technique that can be used to prevent the return of fear in humans. In the present study, unconditioned stimulus revaluation was applied in the retrieval-extinction paradigm to investi...

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Autores principales:	Xiang-Xing Zeng, Juan Du, Chu-Qun Zhuang, Jun-Hua Zhang, Yan-Lei Jia, Xi-Fu Zheng
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/312ec70db0de44ae83abf03bff7f79b0
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spelling	oai:doaj.org-article:312ec70db0de44ae83abf03bff7f79b02021-11-25T06:08:04ZUnconditioned stimulus revaluation to promote conditioned fear extinction in the memory reconsolidation window.1932-620310.1371/journal.pone.0101589https://doaj.org/article/312ec70db0de44ae83abf03bff7f79b02014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25033450/?tool=EBIhttps://doaj.org/toc/1932-6203The retrieval-extinction paradigm, which disrupts the reconsolidation of fear memories in humans, is a non-invasive technique that can be used to prevent the return of fear in humans. In the present study, unconditioned stimulus revaluation was applied in the retrieval-extinction paradigm to investigate its promotion of conditioned fear extinction in the memory reconsolidation window after participants acquired conditioned fear. This experiment comprised three stages (acquisition, unconditioned stimulus revaluation, retrieval-extinction) and three methods for indexing fear (unconditioned stimulus expectancy, skin conductance response, conditioned stimulus pleasure rating). After the acquisition phase, we decreased the intensity of the unconditioned stimulus in one group (devaluation) and maintained constant for the other group (control). The results indicated that both groups exhibited similar levels of unconditioned stimulus expectancy, but the devaluation group had significantly smaller skin conductance responses and exhibited a growth in conditioned stimulus + pleasure. Thus, our findings indicate unconditioned stimulus revaluation effectively promoted the extinction of conditioned fear within the memory reconsolidation window.Xiang-Xing ZengJuan DuChu-Qun ZhuangJun-Hua ZhangYan-Lei JiaXi-Fu ZhengPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 7, p e101589 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xiang-Xing Zeng Juan Du Chu-Qun Zhuang Jun-Hua Zhang Yan-Lei Jia Xi-Fu Zheng Unconditioned stimulus revaluation to promote conditioned fear extinction in the memory reconsolidation window.
description	The retrieval-extinction paradigm, which disrupts the reconsolidation of fear memories in humans, is a non-invasive technique that can be used to prevent the return of fear in humans. In the present study, unconditioned stimulus revaluation was applied in the retrieval-extinction paradigm to investigate its promotion of conditioned fear extinction in the memory reconsolidation window after participants acquired conditioned fear. This experiment comprised three stages (acquisition, unconditioned stimulus revaluation, retrieval-extinction) and three methods for indexing fear (unconditioned stimulus expectancy, skin conductance response, conditioned stimulus pleasure rating). After the acquisition phase, we decreased the intensity of the unconditioned stimulus in one group (devaluation) and maintained constant for the other group (control). The results indicated that both groups exhibited similar levels of unconditioned stimulus expectancy, but the devaluation group had significantly smaller skin conductance responses and exhibited a growth in conditioned stimulus + pleasure. Thus, our findings indicate unconditioned stimulus revaluation effectively promoted the extinction of conditioned fear within the memory reconsolidation window.
format	article
author	Xiang-Xing Zeng Juan Du Chu-Qun Zhuang Jun-Hua Zhang Yan-Lei Jia Xi-Fu Zheng
author_facet	Xiang-Xing Zeng Juan Du Chu-Qun Zhuang Jun-Hua Zhang Yan-Lei Jia Xi-Fu Zheng
author_sort	Xiang-Xing Zeng
title	Unconditioned stimulus revaluation to promote conditioned fear extinction in the memory reconsolidation window.
title_short	Unconditioned stimulus revaluation to promote conditioned fear extinction in the memory reconsolidation window.
title_full	Unconditioned stimulus revaluation to promote conditioned fear extinction in the memory reconsolidation window.
title_fullStr	Unconditioned stimulus revaluation to promote conditioned fear extinction in the memory reconsolidation window.
title_full_unstemmed	Unconditioned stimulus revaluation to promote conditioned fear extinction in the memory reconsolidation window.
title_sort	unconditioned stimulus revaluation to promote conditioned fear extinction in the memory reconsolidation window.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/312ec70db0de44ae83abf03bff7f79b0
work_keys_str_mv	AT xiangxingzeng unconditionedstimulusrevaluationtopromoteconditionedfearextinctioninthememoryreconsolidationwindow AT juandu unconditionedstimulusrevaluationtopromoteconditionedfearextinctioninthememoryreconsolidationwindow AT chuqunzhuang unconditionedstimulusrevaluationtopromoteconditionedfearextinctioninthememoryreconsolidationwindow AT junhuazhang unconditionedstimulusrevaluationtopromoteconditionedfearextinctioninthememoryreconsolidationwindow AT yanleijia unconditionedstimulusrevaluationtopromoteconditionedfearextinctioninthememoryreconsolidationwindow AT xifuzheng unconditionedstimulusrevaluationtopromoteconditionedfearextinctioninthememoryreconsolidationwindow
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Unconditioned stimulus revaluation to promote conditioned fear extinction in the memory reconsolidation window.

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