Aerobic exercise intensity does not affect the anabolic signaling following resistance exercise in endurance athletes

Abstract This study examined whether intensity of endurance stimulus within a concurrent training paradigm influenced the phosphorylation of signaling proteins associated with the mTOR and AMPK networks. Eight male cyclists completed (1) resistance exercise (RES), 6 × 8 squats at 80% 1-RM; (2) resis...

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Autores principales:	T. W. Jones, L. Eddens, J. Kupusarevic, D. C. M. Simoes, M. J. W. Furber, K. A. van Someren, G. Howatson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3131fe4a99774a7387f9c1e54e7a7f28
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spelling	oai:doaj.org-article:3131fe4a99774a7387f9c1e54e7a7f282021-12-02T14:49:17ZAerobic exercise intensity does not affect the anabolic signaling following resistance exercise in endurance athletes10.1038/s41598-021-90274-82045-2322https://doaj.org/article/3131fe4a99774a7387f9c1e54e7a7f282021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90274-8https://doaj.org/toc/2045-2322Abstract This study examined whether intensity of endurance stimulus within a concurrent training paradigm influenced the phosphorylation of signaling proteins associated with the mTOR and AMPK networks. Eight male cyclists completed (1) resistance exercise (RES), 6 × 8 squats at 80% 1-RM; (2) resistance exercise and moderate intensity cycling of 40 min at 65% V̇O2peak, (RES + MIC); (3) resistance exercise and high intensity interval cycling of 40 min with 6 alternating 3 min intervals of 85 and 45% V̇O2peak (RES + HIIC), in a cross-over design. Muscle biopsies were collected at rest and 3 h post-RES. There was a main effect of condition for mTORS2448 (p = 0.043), with a greater response in the RES + MIC relative to RES condition (p = 0.033). There was a main effect of condition for AMPKα2T172 (p = 0.041), with a greater response in RES + MIC, relative to both RES + HIIC (p = 0.026) and RES (p = 0.046). There were no other condition effects for the remaining protein kinases assessed (p > 0.05). These data do not support a molecular interference effect in cyclists under controlled conditions. There was no intensity-dependent regulation of AMPK, nor differential activation of anabolism with the manipulation of endurance exercise intensity.T. W. JonesL. EddensJ. KupusarevicD. C. M. SimoesM. J. W. FurberK. A. van SomerenG. HowatsonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q T. W. Jones L. Eddens J. Kupusarevic D. C. M. Simoes M. J. W. Furber K. A. van Someren G. Howatson Aerobic exercise intensity does not affect the anabolic signaling following resistance exercise in endurance athletes
description	Abstract This study examined whether intensity of endurance stimulus within a concurrent training paradigm influenced the phosphorylation of signaling proteins associated with the mTOR and AMPK networks. Eight male cyclists completed (1) resistance exercise (RES), 6 × 8 squats at 80% 1-RM; (2) resistance exercise and moderate intensity cycling of 40 min at 65% V̇O2peak, (RES + MIC); (3) resistance exercise and high intensity interval cycling of 40 min with 6 alternating 3 min intervals of 85 and 45% V̇O2peak (RES + HIIC), in a cross-over design. Muscle biopsies were collected at rest and 3 h post-RES. There was a main effect of condition for mTORS2448 (p = 0.043), with a greater response in the RES + MIC relative to RES condition (p = 0.033). There was a main effect of condition for AMPKα2T172 (p = 0.041), with a greater response in RES + MIC, relative to both RES + HIIC (p = 0.026) and RES (p = 0.046). There were no other condition effects for the remaining protein kinases assessed (p > 0.05). These data do not support a molecular interference effect in cyclists under controlled conditions. There was no intensity-dependent regulation of AMPK, nor differential activation of anabolism with the manipulation of endurance exercise intensity.
format	article
author	T. W. Jones L. Eddens J. Kupusarevic D. C. M. Simoes M. J. W. Furber K. A. van Someren G. Howatson
author_facet	T. W. Jones L. Eddens J. Kupusarevic D. C. M. Simoes M. J. W. Furber K. A. van Someren G. Howatson
author_sort	T. W. Jones
title	Aerobic exercise intensity does not affect the anabolic signaling following resistance exercise in endurance athletes
title_short	Aerobic exercise intensity does not affect the anabolic signaling following resistance exercise in endurance athletes
title_full	Aerobic exercise intensity does not affect the anabolic signaling following resistance exercise in endurance athletes
title_fullStr	Aerobic exercise intensity does not affect the anabolic signaling following resistance exercise in endurance athletes
title_full_unstemmed	Aerobic exercise intensity does not affect the anabolic signaling following resistance exercise in endurance athletes
title_sort	aerobic exercise intensity does not affect the anabolic signaling following resistance exercise in endurance athletes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3131fe4a99774a7387f9c1e54e7a7f28
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Aerobic exercise intensity does not affect the anabolic signaling following resistance exercise in endurance athletes

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