A patient-specific lumped-parameter model of coronary circulation

Abstract A new lumped-parameter model for coronary hemodynamics is developed. This model is developed for the whole coronary network based on CT scans of a patient-specific geometry including the right coronary tree, which is absent in many previous mathematical models. The model adopts the structur...

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Autores principales:	Zheng Duanmu, Min Yin, Xueling Fan, Xilan Yang, Xiaoyu Luo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/313841bdf1c24de38ad98a5c0aebff33
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spelling	oai:doaj.org-article:313841bdf1c24de38ad98a5c0aebff332021-12-02T15:08:16ZA patient-specific lumped-parameter model of coronary circulation10.1038/s41598-018-19164-w2045-2322https://doaj.org/article/313841bdf1c24de38ad98a5c0aebff332018-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-19164-whttps://doaj.org/toc/2045-2322Abstract A new lumped-parameter model for coronary hemodynamics is developed. This model is developed for the whole coronary network based on CT scans of a patient-specific geometry including the right coronary tree, which is absent in many previous mathematical models. The model adopts the structured tree model boundary conditions similar to the work of Olufsen et al., thus avoiding the necessity of invasive perfusion measurements. In addition, we also incorporated the effects of the head loss at the two inlets of the large coronary arteries for the first time. The head loss could explain the phenomenon of a sudden increase of the resistance at the inlet of coronary vessel. The estimated blood pressure and flow rate results from the model agree well with the clinical measurements. The computed impedances also match the experimental perfusion measurement. The effects of coronary arterial stenosis are considered and the fractional flow reserve and relative flow in the coronary vessels for a stenotic vessel computed in this model show good agreement with published experimental data. It is believed that the approach could be readily translated to clinical practice to facilitate real time clinical diagnosis.Zheng DuanmuMin YinXueling FanXilan YangXiaoyu LuoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Zheng Duanmu Min Yin Xueling Fan Xilan Yang Xiaoyu Luo A patient-specific lumped-parameter model of coronary circulation
description	Abstract A new lumped-parameter model for coronary hemodynamics is developed. This model is developed for the whole coronary network based on CT scans of a patient-specific geometry including the right coronary tree, which is absent in many previous mathematical models. The model adopts the structured tree model boundary conditions similar to the work of Olufsen et al., thus avoiding the necessity of invasive perfusion measurements. In addition, we also incorporated the effects of the head loss at the two inlets of the large coronary arteries for the first time. The head loss could explain the phenomenon of a sudden increase of the resistance at the inlet of coronary vessel. The estimated blood pressure and flow rate results from the model agree well with the clinical measurements. The computed impedances also match the experimental perfusion measurement. The effects of coronary arterial stenosis are considered and the fractional flow reserve and relative flow in the coronary vessels for a stenotic vessel computed in this model show good agreement with published experimental data. It is believed that the approach could be readily translated to clinical practice to facilitate real time clinical diagnosis.
format	article
author	Zheng Duanmu Min Yin Xueling Fan Xilan Yang Xiaoyu Luo
author_facet	Zheng Duanmu Min Yin Xueling Fan Xilan Yang Xiaoyu Luo
author_sort	Zheng Duanmu
title	A patient-specific lumped-parameter model of coronary circulation
title_short	A patient-specific lumped-parameter model of coronary circulation
title_full	A patient-specific lumped-parameter model of coronary circulation
title_fullStr	A patient-specific lumped-parameter model of coronary circulation
title_full_unstemmed	A patient-specific lumped-parameter model of coronary circulation
title_sort	patient-specific lumped-parameter model of coronary circulation
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/313841bdf1c24de38ad98a5c0aebff33
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A patient-specific lumped-parameter model of coronary circulation

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