Elevated 5hmC levels characterize DNA of the cerebellum in Parkinson’s disease

Abstract 5-methylcytosine and the oxidation product 5-hydroxymethylcytosine are two prominent epigenetic variants of the cytosine base in nuclear DNA of mammalian brains. We measured levels of 5-methylcytosine and 5-hydroxymethylcytosine by enzyme-linked immunosorbent assay in DNA from post-mortem c...

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Autores principales:	Reinhard Stöger, Paula J. Scaife, Freya Shephard, Lisa Chakrabarti
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/313bead6c40041298b4aafaba6c38a62
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spelling	oai:doaj.org-article:313bead6c40041298b4aafaba6c38a622021-12-02T15:10:26ZElevated 5hmC levels characterize DNA of the cerebellum in Parkinson’s disease10.1038/s41531-017-0007-32373-8057https://doaj.org/article/313bead6c40041298b4aafaba6c38a622017-02-01T00:00:00Zhttps://doi.org/10.1038/s41531-017-0007-3https://doaj.org/toc/2373-8057Abstract 5-methylcytosine and the oxidation product 5-hydroxymethylcytosine are two prominent epigenetic variants of the cytosine base in nuclear DNA of mammalian brains. We measured levels of 5-methylcytosine and 5-hydroxymethylcytosine by enzyme-linked immunosorbent assay in DNA from post-mortem cerebella of individuals with Parkinson’s disease and age-matched controls. 5-methylcytosine levels showed no significant differences between Parkinson’s disease and control DNA sample sets. In contrast, median 5-hydroxymethylcytosine levels were almost twice as high (p < 0.001) in both male and female Parkinson’s disease individuals compared with controls. The distinct epigenetic profile identified in cerebellar DNA of Parkinson’s disease patients raises the question whether elevated 5-hydroxymethylcytosine levels are a driver or a consequence of Parkinson’s disease.Reinhard StögerPaula J. ScaifeFreya ShephardLisa ChakrabartiNature PortfolioarticleNeurology. Diseases of the nervous systemRC346-429ENnpj Parkinson's Disease, Vol 3, Iss 1, Pp 1-3 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurology. Diseases of the nervous system RC346-429 Reinhard Stöger Paula J. Scaife Freya Shephard Lisa Chakrabarti Elevated 5hmC levels characterize DNA of the cerebellum in Parkinson’s disease
description	Abstract 5-methylcytosine and the oxidation product 5-hydroxymethylcytosine are two prominent epigenetic variants of the cytosine base in nuclear DNA of mammalian brains. We measured levels of 5-methylcytosine and 5-hydroxymethylcytosine by enzyme-linked immunosorbent assay in DNA from post-mortem cerebella of individuals with Parkinson’s disease and age-matched controls. 5-methylcytosine levels showed no significant differences between Parkinson’s disease and control DNA sample sets. In contrast, median 5-hydroxymethylcytosine levels were almost twice as high (p < 0.001) in both male and female Parkinson’s disease individuals compared with controls. The distinct epigenetic profile identified in cerebellar DNA of Parkinson’s disease patients raises the question whether elevated 5-hydroxymethylcytosine levels are a driver or a consequence of Parkinson’s disease.
format	article
author	Reinhard Stöger Paula J. Scaife Freya Shephard Lisa Chakrabarti
author_facet	Reinhard Stöger Paula J. Scaife Freya Shephard Lisa Chakrabarti
author_sort	Reinhard Stöger
title	Elevated 5hmC levels characterize DNA of the cerebellum in Parkinson’s disease
title_short	Elevated 5hmC levels characterize DNA of the cerebellum in Parkinson’s disease
title_full	Elevated 5hmC levels characterize DNA of the cerebellum in Parkinson’s disease
title_fullStr	Elevated 5hmC levels characterize DNA of the cerebellum in Parkinson’s disease
title_full_unstemmed	Elevated 5hmC levels characterize DNA of the cerebellum in Parkinson’s disease
title_sort	elevated 5hmc levels characterize dna of the cerebellum in parkinson’s disease
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/313bead6c40041298b4aafaba6c38a62
work_keys_str_mv	AT reinhardstoger elevated5hmclevelscharacterizednaofthecerebelluminparkinsonsdisease AT paulajscaife elevated5hmclevelscharacterizednaofthecerebelluminparkinsonsdisease AT freyashephard elevated5hmclevelscharacterizednaofthecerebelluminparkinsonsdisease AT lisachakrabarti elevated5hmclevelscharacterizednaofthecerebelluminparkinsonsdisease
_version_	1718387681958821888

Elevated 5hmC levels characterize DNA of the cerebellum in Parkinson’s disease

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