The Factors Influencing the Renal Glucose Threshold in Patients with Newly Diagnosed Type 2 Diabetes Mellitus

Shan-Shan Cui,1 Li-Jun Duan,1 Jun-Feng Li,1 Yong-Zhang Qin,2 Su-Qing Bao,1 Xia Jiang1 1Department of Endocrinology and Metabolism, Tianjin First Central Hospital, Tianjin, People’s Republic of China; 2Department of Endocrinology, First Affiliated Hospital of Gannan Medical University, Ganzhou, Peopl...

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Autores principales:	Cui SS, Duan LJ, Li JF, Qin YZ, Bao SQ, Jiang X
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	newly diagnosed type 2 diabetes mellitus renal glucose threshold continuous glucose monitoring Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/313ceffeacc3452e9d876d317a3db50b
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spelling	oai:doaj.org-article:313ceffeacc3452e9d876d317a3db50b2021-12-02T19:36:19ZThe Factors Influencing the Renal Glucose Threshold in Patients with Newly Diagnosed Type 2 Diabetes Mellitus1178-7007https://doaj.org/article/313ceffeacc3452e9d876d317a3db50b2021-11-01T00:00:00Zhttps://www.dovepress.com/the-factors-influencing-the-renal-glucose-threshold-in-patients-with-n-peer-reviewed-fulltext-article-DMSOhttps://doaj.org/toc/1178-7007Shan-Shan Cui,1 Li-Jun Duan,1 Jun-Feng Li,1 Yong-Zhang Qin,2 Su-Qing Bao,1 Xia Jiang1 1Department of Endocrinology and Metabolism, Tianjin First Central Hospital, Tianjin, People’s Republic of China; 2Department of Endocrinology, First Affiliated Hospital of Gannan Medical University, Ganzhou, People’s Republic of ChinaCorrespondence: Shan-Shan CuiDepartment of Endocrinology and Metabolism, Tianjin First Central Hospital, No. 24 of Fukang Road, Nankai District, Tianjin, People’s Republic of ChinaTel +86 15022353629Email shanshan87@tom.comObjective: This study aims to explore the factors influencing the renal glucose threshold (RTG) in patients with newly diagnosed type 2 diabetes mellitus (T2DM).Methods: A cross-sectional study was conducted on 1009 hospitalized patients with T2DM using stratified random sampling. Blood glucose was monitored using a dynamic blood glucose monitor to obtain the mean blood glucose (MBG), which is used to calculate the RTG. The factors influencing the RTG were then analyzed.Results: The mean RTG in patients with newly diagnosed T2DM was 203.58 ± 55.22 mg/dl. The correlation between the RTG and the various variables was analyzed, and the results demonstrated that the RTG was correlated with the patient’s age (r = − 0.14539, P = 0.0001); MBG (r = − 0.35009, P = 0.0001); renal long neck (r = 0.16762, P = 0.0001); homeostatic model assessment for insulin resistance (r = − 0.38322, P = 0.0001); homeostatic model assessment for beta-cell function (r = − 0.22770, P = 0.0001); and the levels of glycated hemoglobin (HbA1c; r = 0.98994, P = 0.0001), blood urea nitrogen (r = − 0.11093, P = 0.0004), creatinine (r = − 0.26414, P = 0.0001), uric acid (r = − 0.20149, P = 0.0001), total cholesterol (r = 0.13192, P = 0.0001), low-density lipoprotein (r = 0.12466, P = 0.0001), thyroid-stimulating hormone (r = − 0.06346, P = 0.0460), beta-2 microglobulin (r = − 0.08884, P = 0.0056), and 24-hour urine glucose (r = 0.32115, P = 0.0001). Multiple linear stepwise regression analysis revealed that the HbA1c, 24-hour urine glucose, estimated glomerular filtration rate (eGFR), D-dimer, and body mass index (BMI) should be included in the final model, and HbA1c had the greatest impact on the RTG followed in descending order by the 24-hour urine glucose, eGFR, D-dimer, and BMI (P < 0.05).Conclusion: The RTG increases in most patients with newly diagnosed diabetes. The risk factors for the RTG are HbA1c, 24-hour urine glucose, eGFR, D-dimer, and BMI.Keywords: newly diagnosed, type 2 diabetes mellitus, renal glucose threshold, continuous glucose monitoringCui SSDuan LJLi JFQin YZBao SQJiang XDove Medical Pressarticlenewly diagnosedtype 2 diabetes mellitusrenal glucose thresholdcontinuous glucose monitoringSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 14, Pp 4497-4503 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	newly diagnosed type 2 diabetes mellitus renal glucose threshold continuous glucose monitoring Specialties of internal medicine RC581-951
spellingShingle	newly diagnosed type 2 diabetes mellitus renal glucose threshold continuous glucose monitoring Specialties of internal medicine RC581-951 Cui SS Duan LJ Li JF Qin YZ Bao SQ Jiang X The Factors Influencing the Renal Glucose Threshold in Patients with Newly Diagnosed Type 2 Diabetes Mellitus
description	Shan-Shan Cui,1 Li-Jun Duan,1 Jun-Feng Li,1 Yong-Zhang Qin,2 Su-Qing Bao,1 Xia Jiang1 1Department of Endocrinology and Metabolism, Tianjin First Central Hospital, Tianjin, People’s Republic of China; 2Department of Endocrinology, First Affiliated Hospital of Gannan Medical University, Ganzhou, People’s Republic of ChinaCorrespondence: Shan-Shan CuiDepartment of Endocrinology and Metabolism, Tianjin First Central Hospital, No. 24 of Fukang Road, Nankai District, Tianjin, People’s Republic of ChinaTel +86 15022353629Email shanshan87@tom.comObjective: This study aims to explore the factors influencing the renal glucose threshold (RTG) in patients with newly diagnosed type 2 diabetes mellitus (T2DM).Methods: A cross-sectional study was conducted on 1009 hospitalized patients with T2DM using stratified random sampling. Blood glucose was monitored using a dynamic blood glucose monitor to obtain the mean blood glucose (MBG), which is used to calculate the RTG. The factors influencing the RTG were then analyzed.Results: The mean RTG in patients with newly diagnosed T2DM was 203.58 ± 55.22 mg/dl. The correlation between the RTG and the various variables was analyzed, and the results demonstrated that the RTG was correlated with the patient’s age (r = − 0.14539, P = 0.0001); MBG (r = − 0.35009, P = 0.0001); renal long neck (r = 0.16762, P = 0.0001); homeostatic model assessment for insulin resistance (r = − 0.38322, P = 0.0001); homeostatic model assessment for beta-cell function (r = − 0.22770, P = 0.0001); and the levels of glycated hemoglobin (HbA1c; r = 0.98994, P = 0.0001), blood urea nitrogen (r = − 0.11093, P = 0.0004), creatinine (r = − 0.26414, P = 0.0001), uric acid (r = − 0.20149, P = 0.0001), total cholesterol (r = 0.13192, P = 0.0001), low-density lipoprotein (r = 0.12466, P = 0.0001), thyroid-stimulating hormone (r = − 0.06346, P = 0.0460), beta-2 microglobulin (r = − 0.08884, P = 0.0056), and 24-hour urine glucose (r = 0.32115, P = 0.0001). Multiple linear stepwise regression analysis revealed that the HbA1c, 24-hour urine glucose, estimated glomerular filtration rate (eGFR), D-dimer, and body mass index (BMI) should be included in the final model, and HbA1c had the greatest impact on the RTG followed in descending order by the 24-hour urine glucose, eGFR, D-dimer, and BMI (P < 0.05).Conclusion: The RTG increases in most patients with newly diagnosed diabetes. The risk factors for the RTG are HbA1c, 24-hour urine glucose, eGFR, D-dimer, and BMI.Keywords: newly diagnosed, type 2 diabetes mellitus, renal glucose threshold, continuous glucose monitoring
format	article
author	Cui SS Duan LJ Li JF Qin YZ Bao SQ Jiang X
author_facet	Cui SS Duan LJ Li JF Qin YZ Bao SQ Jiang X
author_sort	Cui SS
title	The Factors Influencing the Renal Glucose Threshold in Patients with Newly Diagnosed Type 2 Diabetes Mellitus
title_short	The Factors Influencing the Renal Glucose Threshold in Patients with Newly Diagnosed Type 2 Diabetes Mellitus
title_full	The Factors Influencing the Renal Glucose Threshold in Patients with Newly Diagnosed Type 2 Diabetes Mellitus
title_fullStr	The Factors Influencing the Renal Glucose Threshold in Patients with Newly Diagnosed Type 2 Diabetes Mellitus
title_full_unstemmed	The Factors Influencing the Renal Glucose Threshold in Patients with Newly Diagnosed Type 2 Diabetes Mellitus
title_sort	factors influencing the renal glucose threshold in patients with newly diagnosed type 2 diabetes mellitus
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/313ceffeacc3452e9d876d317a3db50b
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The Factors Influencing the Renal Glucose Threshold in Patients with Newly Diagnosed Type 2 Diabetes Mellitus

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