Hepatic p63 regulates steatosis via IKKβ/ER stress

p53 regulates lipid metabolism and fatty acid oxidation, and its inactivation promotes diet-induced liver steatosis. Here Porteiroet al. show that p53 deficiency leads to compensatory p63 upregulation, which, in turn, triggers endoplasmic reticulum stress through IKKβ activation, fatty acid synthesi...

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Autores principales:	Begoña Porteiro, Marcos F. Fondevila, Teresa C. Delgado, Cristina Iglesias, Monica Imbernon, Paula Iruzubieta, Javier Crespo, Amaia Zabala-Letona, Johan Fernø, Bárbara González-Terán, Nuria Matesanz, Lourdes Hernández-Cosido, Miguel Marcos, Sulay Tovar, Anxo Vidal, Julia Sánchez-Ceinos, Maria M. Malagon, Celia Pombo, Juan Zalvide, Arkaitz Carracedo, Xabier Buque, Carlos Dieguez, Guadalupe Sabio, Miguel López, Patricia Aspichueta, María L. Martínez-Chantar, Ruben Nogueiras
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/313d0cad52134cc688396b50bf36ea35
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spelling	oai:doaj.org-article:313d0cad52134cc688396b50bf36ea352021-12-02T17:06:09ZHepatic p63 regulates steatosis via IKKβ/ER stress10.1038/ncomms151112041-1723https://doaj.org/article/313d0cad52134cc688396b50bf36ea352017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15111https://doaj.org/toc/2041-1723p53 regulates lipid metabolism and fatty acid oxidation, and its inactivation promotes diet-induced liver steatosis. Here Porteiroet al. show that p53 deficiency leads to compensatory p63 upregulation, which, in turn, triggers endoplasmic reticulum stress through IKKβ activation, fatty acid synthesis and lipid accumulation.Begoña PorteiroMarcos F. FondevilaTeresa C. DelgadoCristina IglesiasMonica ImbernonPaula IruzubietaJavier CrespoAmaia Zabala-LetonaJohan FernøBárbara González-TeránNuria MatesanzLourdes Hernández-CosidoMiguel MarcosSulay TovarAnxo VidalJulia Sánchez-CeinosMaria M. MalagonCelia PomboJuan ZalvideArkaitz CarracedoXabier BuqueCarlos DieguezGuadalupe SabioMiguel LópezPatricia AspichuetaMaría L. Martínez-ChantarRuben NogueirasNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-19 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Begoña Porteiro Marcos F. Fondevila Teresa C. Delgado Cristina Iglesias Monica Imbernon Paula Iruzubieta Javier Crespo Amaia Zabala-Letona Johan Fernø Bárbara González-Terán Nuria Matesanz Lourdes Hernández-Cosido Miguel Marcos Sulay Tovar Anxo Vidal Julia Sánchez-Ceinos Maria M. Malagon Celia Pombo Juan Zalvide Arkaitz Carracedo Xabier Buque Carlos Dieguez Guadalupe Sabio Miguel López Patricia Aspichueta María L. Martínez-Chantar Ruben Nogueiras Hepatic p63 regulates steatosis via IKKβ/ER stress
description	p53 regulates lipid metabolism and fatty acid oxidation, and its inactivation promotes diet-induced liver steatosis. Here Porteiroet al. show that p53 deficiency leads to compensatory p63 upregulation, which, in turn, triggers endoplasmic reticulum stress through IKKβ activation, fatty acid synthesis and lipid accumulation.
format	article
author	Begoña Porteiro Marcos F. Fondevila Teresa C. Delgado Cristina Iglesias Monica Imbernon Paula Iruzubieta Javier Crespo Amaia Zabala-Letona Johan Fernø Bárbara González-Terán Nuria Matesanz Lourdes Hernández-Cosido Miguel Marcos Sulay Tovar Anxo Vidal Julia Sánchez-Ceinos Maria M. Malagon Celia Pombo Juan Zalvide Arkaitz Carracedo Xabier Buque Carlos Dieguez Guadalupe Sabio Miguel López Patricia Aspichueta María L. Martínez-Chantar Ruben Nogueiras
author_facet	Begoña Porteiro Marcos F. Fondevila Teresa C. Delgado Cristina Iglesias Monica Imbernon Paula Iruzubieta Javier Crespo Amaia Zabala-Letona Johan Fernø Bárbara González-Terán Nuria Matesanz Lourdes Hernández-Cosido Miguel Marcos Sulay Tovar Anxo Vidal Julia Sánchez-Ceinos Maria M. Malagon Celia Pombo Juan Zalvide Arkaitz Carracedo Xabier Buque Carlos Dieguez Guadalupe Sabio Miguel López Patricia Aspichueta María L. Martínez-Chantar Ruben Nogueiras
author_sort	Begoña Porteiro
title	Hepatic p63 regulates steatosis via IKKβ/ER stress
title_short	Hepatic p63 regulates steatosis via IKKβ/ER stress
title_full	Hepatic p63 regulates steatosis via IKKβ/ER stress
title_fullStr	Hepatic p63 regulates steatosis via IKKβ/ER stress
title_full_unstemmed	Hepatic p63 regulates steatosis via IKKβ/ER stress
title_sort	hepatic p63 regulates steatosis via ikkβ/er stress
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/313d0cad52134cc688396b50bf36ea35
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Hepatic p63 regulates steatosis via IKKβ/ER stress

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