Targeting the Gut Mucosal Immune System Using Nanomaterials

The gastrointestinal (GI) tract is one the biggest mucosal surface in the body and one of the primary targets for the delivery of therapeutics, including immunotherapies. GI diseases, including, e.g., inflammatory bowel disease and intestinal infections such as cholera, pose a significant public hea...

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Autores principales:	Jacob McCright, Ann Ramirez, Mayowa Amosu, Arnav Sinha, Amanda Bogseth, Katharina Maisel
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	gastrointestinal tract lymph node gut-associated lymphoid tissues immunotherapy vaccine lectins Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/313dc876e5ae4a15b37820d1f9ca1b21
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spelling	oai:doaj.org-article:313dc876e5ae4a15b37820d1f9ca1b212021-11-25T18:40:23ZTargeting the Gut Mucosal Immune System Using Nanomaterials10.3390/pharmaceutics131117551999-4923https://doaj.org/article/313dc876e5ae4a15b37820d1f9ca1b212021-10-01T00:00:00Zhttps://www.mdpi.com/1999-4923/13/11/1755https://doaj.org/toc/1999-4923The gastrointestinal (GI) tract is one the biggest mucosal surface in the body and one of the primary targets for the delivery of therapeutics, including immunotherapies. GI diseases, including, e.g., inflammatory bowel disease and intestinal infections such as cholera, pose a significant public health burden and are on the rise. Many of these diseases involve inflammatory processes that can be targeted by immune modulatory therapeutics. However, nonspecific targeting of inflammation systemically can lead to significant side effects. This can be avoided by locally targeting therapeutics to the GI tract and its mucosal immune system. In this review, we discuss nanomaterial-based strategies targeting the GI mucosal immune system, including gut-associated lymphoid tissues, tissue resident immune cells, as well as GI lymph nodes, to modulate GI inflammation and disease outcomes, as well as take advantage of some of the primary mechanisms of GI immunity such as oral tolerance.Jacob McCrightAnn RamirezMayowa AmosuArnav SinhaAmanda BogsethKatharina MaiselMDPI AGarticlegastrointestinal tractlymph nodegut-associated lymphoid tissuesimmunotherapyvaccinelectinsPharmacy and materia medicaRS1-441ENPharmaceutics, Vol 13, Iss 1755, p 1755 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	gastrointestinal tract lymph node gut-associated lymphoid tissues immunotherapy vaccine lectins Pharmacy and materia medica RS1-441
spellingShingle	gastrointestinal tract lymph node gut-associated lymphoid tissues immunotherapy vaccine lectins Pharmacy and materia medica RS1-441 Jacob McCright Ann Ramirez Mayowa Amosu Arnav Sinha Amanda Bogseth Katharina Maisel Targeting the Gut Mucosal Immune System Using Nanomaterials
description	The gastrointestinal (GI) tract is one the biggest mucosal surface in the body and one of the primary targets for the delivery of therapeutics, including immunotherapies. GI diseases, including, e.g., inflammatory bowel disease and intestinal infections such as cholera, pose a significant public health burden and are on the rise. Many of these diseases involve inflammatory processes that can be targeted by immune modulatory therapeutics. However, nonspecific targeting of inflammation systemically can lead to significant side effects. This can be avoided by locally targeting therapeutics to the GI tract and its mucosal immune system. In this review, we discuss nanomaterial-based strategies targeting the GI mucosal immune system, including gut-associated lymphoid tissues, tissue resident immune cells, as well as GI lymph nodes, to modulate GI inflammation and disease outcomes, as well as take advantage of some of the primary mechanisms of GI immunity such as oral tolerance.
format	article
author	Jacob McCright Ann Ramirez Mayowa Amosu Arnav Sinha Amanda Bogseth Katharina Maisel
author_facet	Jacob McCright Ann Ramirez Mayowa Amosu Arnav Sinha Amanda Bogseth Katharina Maisel
author_sort	Jacob McCright
title	Targeting the Gut Mucosal Immune System Using Nanomaterials
title_short	Targeting the Gut Mucosal Immune System Using Nanomaterials
title_full	Targeting the Gut Mucosal Immune System Using Nanomaterials
title_fullStr	Targeting the Gut Mucosal Immune System Using Nanomaterials
title_full_unstemmed	Targeting the Gut Mucosal Immune System Using Nanomaterials
title_sort	targeting the gut mucosal immune system using nanomaterials
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/313dc876e5ae4a15b37820d1f9ca1b21
work_keys_str_mv	AT jacobmccright targetingthegutmucosalimmunesystemusingnanomaterials AT annramirez targetingthegutmucosalimmunesystemusingnanomaterials AT mayowaamosu targetingthegutmucosalimmunesystemusingnanomaterials AT arnavsinha targetingthegutmucosalimmunesystemusingnanomaterials AT amandabogseth targetingthegutmucosalimmunesystemusingnanomaterials AT katharinamaisel targetingthegutmucosalimmunesystemusingnanomaterials
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Targeting the Gut Mucosal Immune System Using Nanomaterials

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