Genotype-environment interaction on human cognitive function conditioned on the status of breastfeeding and maternal smoking around birth

Abstract We estimated genotype by environment interaction (G × E) on later cognitive performance and educational attainment across four unique environments, i.e. 1) breastfed without maternal smoking, 2) breastfed with maternal smoking, 3) non-breastfed without maternal smoking and 4) non-breastfed...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	S. Hong Lee, W. M. Shalanee P. Weerasinghe, Julius H. J. van der Werf
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/31422cd757134332a89b106443c2196e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:31422cd757134332a89b106443c2196e
record_format	dspace
spelling	oai:doaj.org-article:31422cd757134332a89b106443c2196e2021-12-02T12:32:12ZGenotype-environment interaction on human cognitive function conditioned on the status of breastfeeding and maternal smoking around birth10.1038/s41598-017-06214-y2045-2322https://doaj.org/article/31422cd757134332a89b106443c2196e2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06214-yhttps://doaj.org/toc/2045-2322Abstract We estimated genotype by environment interaction (G × E) on later cognitive performance and educational attainment across four unique environments, i.e. 1) breastfed without maternal smoking, 2) breastfed with maternal smoking, 3) non-breastfed without maternal smoking and 4) non-breastfed with maternal smoking, using a novel design and statistical approach that was facilitated by the availability of datasets with the genome-wide single nucleotide polymorphisms (SNPs). There was significant G × E for both fluid intelligence (p-value = 1.0E-03) and educational attainment (p-value = 8.3E-05) when comparing genetic effects in the group of individuals who were breastfed without maternal smoking with those not breastfed without maternal smoking. There was also significant G × E for fluid intelligence (p-value = 3.9E-05) when comparing the group of individuals who were breastfed with maternal smoking with those not breastfed without maternal smoking. Genome-wide significant SNPs were different between different environmental groups. Genomic prediction accuracies were significantly higher when using the target and discovery sample from the same environmental group than when using those from the different environmental groups. This finding demonstrates G × E has important implications for future studies on the genetic architecture, genome-wide association studies and genomic predictions.S. Hong LeeW. M. Shalanee P. WeerasingheJulius H. J. van der WerfNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q S. Hong Lee W. M. Shalanee P. Weerasinghe Julius H. J. van der Werf Genotype-environment interaction on human cognitive function conditioned on the status of breastfeeding and maternal smoking around birth
description	Abstract We estimated genotype by environment interaction (G × E) on later cognitive performance and educational attainment across four unique environments, i.e. 1) breastfed without maternal smoking, 2) breastfed with maternal smoking, 3) non-breastfed without maternal smoking and 4) non-breastfed with maternal smoking, using a novel design and statistical approach that was facilitated by the availability of datasets with the genome-wide single nucleotide polymorphisms (SNPs). There was significant G × E for both fluid intelligence (p-value = 1.0E-03) and educational attainment (p-value = 8.3E-05) when comparing genetic effects in the group of individuals who were breastfed without maternal smoking with those not breastfed without maternal smoking. There was also significant G × E for fluid intelligence (p-value = 3.9E-05) when comparing the group of individuals who were breastfed with maternal smoking with those not breastfed without maternal smoking. Genome-wide significant SNPs were different between different environmental groups. Genomic prediction accuracies were significantly higher when using the target and discovery sample from the same environmental group than when using those from the different environmental groups. This finding demonstrates G × E has important implications for future studies on the genetic architecture, genome-wide association studies and genomic predictions.
format	article
author	S. Hong Lee W. M. Shalanee P. Weerasinghe Julius H. J. van der Werf
author_facet	S. Hong Lee W. M. Shalanee P. Weerasinghe Julius H. J. van der Werf
author_sort	S. Hong Lee
title	Genotype-environment interaction on human cognitive function conditioned on the status of breastfeeding and maternal smoking around birth
title_short	Genotype-environment interaction on human cognitive function conditioned on the status of breastfeeding and maternal smoking around birth
title_full	Genotype-environment interaction on human cognitive function conditioned on the status of breastfeeding and maternal smoking around birth
title_fullStr	Genotype-environment interaction on human cognitive function conditioned on the status of breastfeeding and maternal smoking around birth
title_full_unstemmed	Genotype-environment interaction on human cognitive function conditioned on the status of breastfeeding and maternal smoking around birth
title_sort	genotype-environment interaction on human cognitive function conditioned on the status of breastfeeding and maternal smoking around birth
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/31422cd757134332a89b106443c2196e
work_keys_str_mv	AT shonglee genotypeenvironmentinteractiononhumancognitivefunctionconditionedonthestatusofbreastfeedingandmaternalsmokingaroundbirth AT wmshalaneepweerasinghe genotypeenvironmentinteractiononhumancognitivefunctionconditionedonthestatusofbreastfeedingandmaternalsmokingaroundbirth AT juliushjvanderwerf genotypeenvironmentinteractiononhumancognitivefunctionconditionedonthestatusofbreastfeedingandmaternalsmokingaroundbirth
_version_	1718394147471097856

Genotype-environment interaction on human cognitive function conditioned on the status of breastfeeding and maternal smoking around birth

Ejemplares similares