Antivirulence Activity of the Human Gut Metabolome

ABSTRACT The mammalian gut contains a complex assembly of commensal microbes termed microbiota. Although much has been learned about the role of these microbes in health, the mechanisms underlying these functions are ill defined. We have recently shown that the mammalian gut contains thousands of sm...

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Autores principales:	L. Caetano M. Antunes, Julie A. K. McDonald, Kathleen Schroeter, Christian Carlucci, Rosana B. R. Ferreira, Melody Wang, Sophie Yurist-Doutsch, Gill Hira, Kevan Jacobson, Julian Davies, Emma Allen-Vercoe, B. Brett Finlay
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2014
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/31426e0979bd4386b6d2703131aafb7d
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spelling	oai:doaj.org-article:31426e0979bd4386b6d2703131aafb7d2021-11-15T15:47:21ZAntivirulence Activity of the Human Gut Metabolome10.1128/mBio.01183-142150-7511https://doaj.org/article/31426e0979bd4386b6d2703131aafb7d2014-08-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.01183-14https://doaj.org/toc/2150-7511ABSTRACT The mammalian gut contains a complex assembly of commensal microbes termed microbiota. Although much has been learned about the role of these microbes in health, the mechanisms underlying these functions are ill defined. We have recently shown that the mammalian gut contains thousands of small molecules, most of which are currently unidentified. Therefore, we hypothesized that these molecules function as chemical cues used by hosts and microbes during their interactions in health and disease. Thus, a search was initiated to identify molecules produced by the microbiota that are sensed by pathogens. We found that a secreted molecule produced by clostridia acts as a strong repressor of Salmonella virulence, obliterating expression of the Salmonella pathogenicity island 1 as well as host cell invasion. It has been known for decades that the microbiota protects its hosts from invading pathogens, and these data suggest that chemical sensing may be involved in this phenomenon. Further investigations should reveal the exact biological role of this molecule as well as its therapeutic potential. IMPORTANCE Microbes can communicate through the production and sensing of small molecules. Within the complex ecosystem formed by commensal microbes living in and on the human body, it is likely that these molecular messages are used extensively during the interactions between different microbial species as well as with host cells. Deciphering such a molecular dialect will be fundamental to our understanding of host-microbe interactions in health and disease and may prove useful for the design of new therapeutic strategies that target these mechanisms of communication.L. Caetano M. AntunesJulie A. K. McDonaldKathleen SchroeterChristian CarlucciRosana B. R. FerreiraMelody WangSophie Yurist-DoutschGill HiraKevan JacobsonJulian DaviesEmma Allen-VercoeB. Brett FinlayAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 5, Iss 4 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 L. Caetano M. Antunes Julie A. K. McDonald Kathleen Schroeter Christian Carlucci Rosana B. R. Ferreira Melody Wang Sophie Yurist-Doutsch Gill Hira Kevan Jacobson Julian Davies Emma Allen-Vercoe B. Brett Finlay Antivirulence Activity of the Human Gut Metabolome
description	ABSTRACT The mammalian gut contains a complex assembly of commensal microbes termed microbiota. Although much has been learned about the role of these microbes in health, the mechanisms underlying these functions are ill defined. We have recently shown that the mammalian gut contains thousands of small molecules, most of which are currently unidentified. Therefore, we hypothesized that these molecules function as chemical cues used by hosts and microbes during their interactions in health and disease. Thus, a search was initiated to identify molecules produced by the microbiota that are sensed by pathogens. We found that a secreted molecule produced by clostridia acts as a strong repressor of Salmonella virulence, obliterating expression of the Salmonella pathogenicity island 1 as well as host cell invasion. It has been known for decades that the microbiota protects its hosts from invading pathogens, and these data suggest that chemical sensing may be involved in this phenomenon. Further investigations should reveal the exact biological role of this molecule as well as its therapeutic potential. IMPORTANCE Microbes can communicate through the production and sensing of small molecules. Within the complex ecosystem formed by commensal microbes living in and on the human body, it is likely that these molecular messages are used extensively during the interactions between different microbial species as well as with host cells. Deciphering such a molecular dialect will be fundamental to our understanding of host-microbe interactions in health and disease and may prove useful for the design of new therapeutic strategies that target these mechanisms of communication.
format	article
author	L. Caetano M. Antunes Julie A. K. McDonald Kathleen Schroeter Christian Carlucci Rosana B. R. Ferreira Melody Wang Sophie Yurist-Doutsch Gill Hira Kevan Jacobson Julian Davies Emma Allen-Vercoe B. Brett Finlay
author_facet	L. Caetano M. Antunes Julie A. K. McDonald Kathleen Schroeter Christian Carlucci Rosana B. R. Ferreira Melody Wang Sophie Yurist-Doutsch Gill Hira Kevan Jacobson Julian Davies Emma Allen-Vercoe B. Brett Finlay
author_sort	L. Caetano M. Antunes
title	Antivirulence Activity of the Human Gut Metabolome
title_short	Antivirulence Activity of the Human Gut Metabolome
title_full	Antivirulence Activity of the Human Gut Metabolome
title_fullStr	Antivirulence Activity of the Human Gut Metabolome
title_full_unstemmed	Antivirulence Activity of the Human Gut Metabolome
title_sort	antivirulence activity of the human gut metabolome
publisher	American Society for Microbiology
publishDate	2014
url	https://doaj.org/article/31426e0979bd4386b6d2703131aafb7d
work_keys_str_mv	AT lcaetanomantunes antivirulenceactivityofthehumangutmetabolome AT julieakmcdonald antivirulenceactivityofthehumangutmetabolome AT kathleenschroeter antivirulenceactivityofthehumangutmetabolome AT christiancarlucci antivirulenceactivityofthehumangutmetabolome AT rosanabrferreira antivirulenceactivityofthehumangutmetabolome AT melodywang antivirulenceactivityofthehumangutmetabolome AT sophieyuristdoutsch antivirulenceactivityofthehumangutmetabolome AT gillhira antivirulenceactivityofthehumangutmetabolome AT kevanjacobson antivirulenceactivityofthehumangutmetabolome AT juliandavies antivirulenceactivityofthehumangutmetabolome AT emmaallenvercoe antivirulenceactivityofthehumangutmetabolome AT bbrettfinlay antivirulenceactivityofthehumangutmetabolome
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Antivirulence Activity of the Human Gut Metabolome

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