A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation
As resident macrophages of the brain, microglia are important for neuroinflammatory responses. This work shows that nuclear factor kappa B regulatory protein A20 is important for microglia activation and regulation during inflammation of the central nervous system.
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Nature Portfolio
2018
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oai:doaj.org-article:3142b0c70aa74f90b3c6f5b5f17ce0662021-12-02T15:33:40ZA20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation10.1038/s41467-018-04376-52041-1723https://doaj.org/article/3142b0c70aa74f90b3c6f5b5f17ce0662018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04376-5https://doaj.org/toc/2041-1723As resident macrophages of the brain, microglia are important for neuroinflammatory responses. This work shows that nuclear factor kappa B regulatory protein A20 is important for microglia activation and regulation during inflammation of the central nervous system.Sofie VoetConor Mc GuireNora HagemeyerArne MartensAnna SchroederPeter WieghoferCarmen DaemsOri StaszewskiLieselotte Vande WalleMarta Joana Costa JordaoMozes SzeHanna-Kaisa VikkulaDelphine DemeestereGriet Van ImschootCharlotte L. ScottEsther HosteAmanda GonçalvesMartin GuilliamsSaskia LippensClaude LibertRoos E. VandenbrouckeKi-Wook KimSteffen JungZsuzsanna Callaerts-VeghPatrick CallaertsJoris de WitMohamed LamkanfiMarco PrinzGeert van LooNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Sofie Voet Conor Mc Guire Nora Hagemeyer Arne Martens Anna Schroeder Peter Wieghofer Carmen Daems Ori Staszewski Lieselotte Vande Walle Marta Joana Costa Jordao Mozes Sze Hanna-Kaisa Vikkula Delphine Demeestere Griet Van Imschoot Charlotte L. Scott Esther Hoste Amanda Gonçalves Martin Guilliams Saskia Lippens Claude Libert Roos E. Vandenbroucke Ki-Wook Kim Steffen Jung Zsuzsanna Callaerts-Vegh Patrick Callaerts Joris de Wit Mohamed Lamkanfi Marco Prinz Geert van Loo A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation |
| description |
As resident macrophages of the brain, microglia are important for neuroinflammatory responses. This work shows that nuclear factor kappa B regulatory protein A20 is important for microglia activation and regulation during inflammation of the central nervous system. |
| format |
article |
| author |
Sofie Voet Conor Mc Guire Nora Hagemeyer Arne Martens Anna Schroeder Peter Wieghofer Carmen Daems Ori Staszewski Lieselotte Vande Walle Marta Joana Costa Jordao Mozes Sze Hanna-Kaisa Vikkula Delphine Demeestere Griet Van Imschoot Charlotte L. Scott Esther Hoste Amanda Gonçalves Martin Guilliams Saskia Lippens Claude Libert Roos E. Vandenbroucke Ki-Wook Kim Steffen Jung Zsuzsanna Callaerts-Vegh Patrick Callaerts Joris de Wit Mohamed Lamkanfi Marco Prinz Geert van Loo |
| author_facet |
Sofie Voet Conor Mc Guire Nora Hagemeyer Arne Martens Anna Schroeder Peter Wieghofer Carmen Daems Ori Staszewski Lieselotte Vande Walle Marta Joana Costa Jordao Mozes Sze Hanna-Kaisa Vikkula Delphine Demeestere Griet Van Imschoot Charlotte L. Scott Esther Hoste Amanda Gonçalves Martin Guilliams Saskia Lippens Claude Libert Roos E. Vandenbroucke Ki-Wook Kim Steffen Jung Zsuzsanna Callaerts-Vegh Patrick Callaerts Joris de Wit Mohamed Lamkanfi Marco Prinz Geert van Loo |
| author_sort |
Sofie Voet |
| title |
A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation |
| title_short |
A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation |
| title_full |
A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation |
| title_fullStr |
A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation |
| title_full_unstemmed |
A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation |
| title_sort |
a20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/3142b0c70aa74f90b3c6f5b5f17ce066 |
| work_keys_str_mv |
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