MANF regulates hypothalamic control of food intake and body weight

MANF is a neurotrophic factor that is secreted but also mediates the unfolded protein response acting intracellularly. Here, the authors show that MANF expression in the brain is influenced by nutritional cues, and hypothalamic MANF influences food intake and systemic energy homeostasis.

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Autores principales:	Su Yang, Huiming Yang, Renbao Chang, Peng Yin, Yang Yang, Weili Yang, Shanshan Huang, Marta A. Gaertig, Shihua Li, Xiao-Jiang Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3145dea6879743cc979c30ea0084a9a5
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spelling	oai:doaj.org-article:3145dea6879743cc979c30ea0084a9a52021-12-02T15:38:36ZMANF regulates hypothalamic control of food intake and body weight10.1038/s41467-017-00750-x2041-1723https://doaj.org/article/3145dea6879743cc979c30ea0084a9a52017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00750-xhttps://doaj.org/toc/2041-1723MANF is a neurotrophic factor that is secreted but also mediates the unfolded protein response acting intracellularly. Here, the authors show that MANF expression in the brain is influenced by nutritional cues, and hypothalamic MANF influences food intake and systemic energy homeostasis.Su YangHuiming YangRenbao ChangPeng YinYang YangWeili YangShanshan HuangMarta A. GaertigShihua LiXiao-Jiang LiNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Su Yang Huiming Yang Renbao Chang Peng Yin Yang Yang Weili Yang Shanshan Huang Marta A. Gaertig Shihua Li Xiao-Jiang Li MANF regulates hypothalamic control of food intake and body weight
description	MANF is a neurotrophic factor that is secreted but also mediates the unfolded protein response acting intracellularly. Here, the authors show that MANF expression in the brain is influenced by nutritional cues, and hypothalamic MANF influences food intake and systemic energy homeostasis.
format	article
author	Su Yang Huiming Yang Renbao Chang Peng Yin Yang Yang Weili Yang Shanshan Huang Marta A. Gaertig Shihua Li Xiao-Jiang Li
author_facet	Su Yang Huiming Yang Renbao Chang Peng Yin Yang Yang Weili Yang Shanshan Huang Marta A. Gaertig Shihua Li Xiao-Jiang Li
author_sort	Su Yang
title	MANF regulates hypothalamic control of food intake and body weight
title_short	MANF regulates hypothalamic control of food intake and body weight
title_full	MANF regulates hypothalamic control of food intake and body weight
title_fullStr	MANF regulates hypothalamic control of food intake and body weight
title_full_unstemmed	MANF regulates hypothalamic control of food intake and body weight
title_sort	manf regulates hypothalamic control of food intake and body weight
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/3145dea6879743cc979c30ea0084a9a5
work_keys_str_mv	AT suyang manfregulateshypothalamiccontroloffoodintakeandbodyweight AT huimingyang manfregulateshypothalamiccontroloffoodintakeandbodyweight AT renbaochang manfregulateshypothalamiccontroloffoodintakeandbodyweight AT pengyin manfregulateshypothalamiccontroloffoodintakeandbodyweight AT yangyang manfregulateshypothalamiccontroloffoodintakeandbodyweight AT weiliyang manfregulateshypothalamiccontroloffoodintakeandbodyweight AT shanshanhuang manfregulateshypothalamiccontroloffoodintakeandbodyweight AT martaagaertig manfregulateshypothalamiccontroloffoodintakeandbodyweight AT shihuali manfregulateshypothalamiccontroloffoodintakeandbodyweight AT xiaojiangli manfregulateshypothalamiccontroloffoodintakeandbodyweight
_version_	1718386102453141504

MANF regulates hypothalamic control of food intake and body weight

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