Genetic drug target validation using Mendelian randomisation

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Genetic drug target validation using Mendelian randomisation

Mendelian randomisation (MR) analysis of drug targets has potential to aid drug development. Here, the authors introduce a mathematical framework to elucidate this specific application of MR.

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Detalles Bibliográficos
Autores principales:	Amand F. Schmidt, Chris Finan, Maria Gordillo-Marañón, Folkert W. Asselbergs, Daniel F. Freitag, Riyaz S. Patel, Benoît Tyl, Sandesh Chopade, Rupert Faraway, Magdalena Zwierzyna, Aroon D. Hingorani
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/314860a99a3044359893ed3a7d40aa29
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

Descripción
Sumario:	Mendelian randomisation (MR) analysis of drug targets has potential to aid drug development. Here, the authors introduce a mathematical framework to elucidate this specific application of MR.