Genetic drug target validation using Mendelian randomisation

Mendelian randomisation (MR) analysis of drug targets has potential to aid drug development. Here, the authors introduce a mathematical framework to elucidate this specific application of MR.

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Detalles Bibliográficos
Autores principales:	Amand F. Schmidt, Chris Finan, Maria Gordillo-Marañón, Folkert W. Asselbergs, Daniel F. Freitag, Riyaz S. Patel, Benoît Tyl, Sandesh Chopade, Rupert Faraway, Magdalena Zwierzyna, Aroon D. Hingorani
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/314860a99a3044359893ed3a7d40aa29
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spelling	oai:doaj.org-article:314860a99a3044359893ed3a7d40aa292021-12-02T17:45:16ZGenetic drug target validation using Mendelian randomisation10.1038/s41467-020-16969-02041-1723https://doaj.org/article/314860a99a3044359893ed3a7d40aa292020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16969-0https://doaj.org/toc/2041-1723Mendelian randomisation (MR) analysis of drug targets has potential to aid drug development. Here, the authors introduce a mathematical framework to elucidate this specific application of MR.Amand F. SchmidtChris FinanMaria Gordillo-MarañónFolkert W. AsselbergsDaniel F. FreitagRiyaz S. PatelBenoît TylSandesh ChopadeRupert FarawayMagdalena ZwierzynaAroon D. HingoraniNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Amand F. Schmidt Chris Finan Maria Gordillo-Marañón Folkert W. Asselbergs Daniel F. Freitag Riyaz S. Patel Benoît Tyl Sandesh Chopade Rupert Faraway Magdalena Zwierzyna Aroon D. Hingorani Genetic drug target validation using Mendelian randomisation
description	Mendelian randomisation (MR) analysis of drug targets has potential to aid drug development. Here, the authors introduce a mathematical framework to elucidate this specific application of MR.
format	article
author	Amand F. Schmidt Chris Finan Maria Gordillo-Marañón Folkert W. Asselbergs Daniel F. Freitag Riyaz S. Patel Benoît Tyl Sandesh Chopade Rupert Faraway Magdalena Zwierzyna Aroon D. Hingorani
author_facet	Amand F. Schmidt Chris Finan Maria Gordillo-Marañón Folkert W. Asselbergs Daniel F. Freitag Riyaz S. Patel Benoît Tyl Sandesh Chopade Rupert Faraway Magdalena Zwierzyna Aroon D. Hingorani
author_sort	Amand F. Schmidt
title	Genetic drug target validation using Mendelian randomisation
title_short	Genetic drug target validation using Mendelian randomisation
title_full	Genetic drug target validation using Mendelian randomisation
title_fullStr	Genetic drug target validation using Mendelian randomisation
title_full_unstemmed	Genetic drug target validation using Mendelian randomisation
title_sort	genetic drug target validation using mendelian randomisation
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/314860a99a3044359893ed3a7d40aa29
work_keys_str_mv	AT amandfschmidt geneticdrugtargetvalidationusingmendelianrandomisation AT chrisfinan geneticdrugtargetvalidationusingmendelianrandomisation AT mariagordillomaranon geneticdrugtargetvalidationusingmendelianrandomisation AT folkertwasselbergs geneticdrugtargetvalidationusingmendelianrandomisation AT danielffreitag geneticdrugtargetvalidationusingmendelianrandomisation AT riyazspatel geneticdrugtargetvalidationusingmendelianrandomisation AT benoittyl geneticdrugtargetvalidationusingmendelianrandomisation AT sandeshchopade geneticdrugtargetvalidationusingmendelianrandomisation AT rupertfaraway geneticdrugtargetvalidationusingmendelianrandomisation AT magdalenazwierzyna geneticdrugtargetvalidationusingmendelianrandomisation AT aroondhingorani geneticdrugtargetvalidationusingmendelianrandomisation
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Genetic drug target validation using Mendelian randomisation

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