Current perspectives on the health risks associated with the consumption of advanced glycation end products: recommendations for dietary management

Sotiria Palimeri,* Eleni Palioura,* Evanthia Diamanti-KandarakisEndocrine Unit, Medical School University of Athens, Athens, Greece*These authors contributed equally to this workAbstract: Advanced glycation end products (AGEs) constitute a complex group of compounds produced endogenously during the...

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Autores principales:	Palimeri S, Palioura E, Diamanti-Kandarakis E
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/314ad5bfecdc47cbaafbde09b92bf2db
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spelling	oai:doaj.org-article:314ad5bfecdc47cbaafbde09b92bf2db2021-12-02T08:15:50ZCurrent perspectives on the health risks associated with the consumption of advanced glycation end products: recommendations for dietary management1178-7007https://doaj.org/article/314ad5bfecdc47cbaafbde09b92bf2db2015-09-01T00:00:00Zhttp://www.dovepress.com/current-perspectives-on-the-health-risks-associated-with-the-consumpti-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Sotiria Palimeri,* Eleni Palioura,* Evanthia Diamanti-KandarakisEndocrine Unit, Medical School University of Athens, Athens, Greece*These authors contributed equally to this workAbstract: Advanced glycation end products (AGEs) constitute a complex group of compounds produced endogenously during the aging process and under conditions of hyperglycemia and oxidative stress. AGEs also have an emerging exogenous origin. Cigarette smoke and diet are the two main exogenous sources of AGEs (glycotoxins). Modern Western diets are rich in AGEs which have been implicated in the pathogenesis of several metabolic and degenerative disorders. Accumulating evidence underlies the beneficial effect of the dietary restriction of AGEs not only in animal studies but also in patients with diabetic complications and metabolic diseases. This article reviews the evidence linking dietary glycotoxins to several disorders from diabetic complications and renal failure to liver dysfunction, female reproduction, eye and cognitive disorders as well as cancer. Furthermore, strategies for AGE reduction are discussed with a focus on dietary modification.Keywords: AGEs, dietary glycotoxins, dietary restriction, PCOS, MSR-1, RAGEPalimeri SPalioura EDiamanti-Kandarakis EDove Medical PressarticleSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol 2015, Iss default, Pp 415-426 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Specialties of internal medicine RC581-951
spellingShingle	Specialties of internal medicine RC581-951 Palimeri S Palioura E Diamanti-Kandarakis E Current perspectives on the health risks associated with the consumption of advanced glycation end products: recommendations for dietary management
description	Sotiria Palimeri,* Eleni Palioura,* Evanthia Diamanti-KandarakisEndocrine Unit, Medical School University of Athens, Athens, Greece*These authors contributed equally to this workAbstract: Advanced glycation end products (AGEs) constitute a complex group of compounds produced endogenously during the aging process and under conditions of hyperglycemia and oxidative stress. AGEs also have an emerging exogenous origin. Cigarette smoke and diet are the two main exogenous sources of AGEs (glycotoxins). Modern Western diets are rich in AGEs which have been implicated in the pathogenesis of several metabolic and degenerative disorders. Accumulating evidence underlies the beneficial effect of the dietary restriction of AGEs not only in animal studies but also in patients with diabetic complications and metabolic diseases. This article reviews the evidence linking dietary glycotoxins to several disorders from diabetic complications and renal failure to liver dysfunction, female reproduction, eye and cognitive disorders as well as cancer. Furthermore, strategies for AGE reduction are discussed with a focus on dietary modification.Keywords: AGEs, dietary glycotoxins, dietary restriction, PCOS, MSR-1, RAGE
format	article
author	Palimeri S Palioura E Diamanti-Kandarakis E
author_facet	Palimeri S Palioura E Diamanti-Kandarakis E
author_sort	Palimeri S
title	Current perspectives on the health risks associated with the consumption of advanced glycation end products: recommendations for dietary management
title_short	Current perspectives on the health risks associated with the consumption of advanced glycation end products: recommendations for dietary management
title_full	Current perspectives on the health risks associated with the consumption of advanced glycation end products: recommendations for dietary management
title_fullStr	Current perspectives on the health risks associated with the consumption of advanced glycation end products: recommendations for dietary management
title_full_unstemmed	Current perspectives on the health risks associated with the consumption of advanced glycation end products: recommendations for dietary management
title_sort	current perspectives on the health risks associated with the consumption of advanced glycation end products: recommendations for dietary management
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/314ad5bfecdc47cbaafbde09b92bf2db
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Current perspectives on the health risks associated with the consumption of advanced glycation end products: recommendations for dietary management

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