Optical coherence tomographic angiography study of perfusion recovery after surgical lowering of intraocular pressure

Abstract We investigated the time and location of retinal perfusion recovery after surgical intraocular pressure (IOP) lowering in glaucoma by using optical coherent tomography angiography (OCTA). Seventeen patients were analyzed. The 4.5 × 4.5-mm OCTA scans centered on the disc were performed preop...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Liang Liu, Hana L. Takusagawa, Miles F. Greenwald, Jie Wang, Brock Alonzo, Beth Edmunds, John C. Morrison, Ou Tan, Yali Jia, David Huang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/314b50f0398f428f929f5a10b8f8c623
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:314b50f0398f428f929f5a10b8f8c623
record_format	dspace
spelling	oai:doaj.org-article:314b50f0398f428f929f5a10b8f8c6232021-12-02T16:34:54ZOptical coherence tomographic angiography study of perfusion recovery after surgical lowering of intraocular pressure10.1038/s41598-021-96225-72045-2322https://doaj.org/article/314b50f0398f428f929f5a10b8f8c6232021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96225-7https://doaj.org/toc/2045-2322Abstract We investigated the time and location of retinal perfusion recovery after surgical intraocular pressure (IOP) lowering in glaucoma by using optical coherent tomography angiography (OCTA). Seventeen patients were analyzed. The 4.5 × 4.5-mm OCTA scans centered on the disc were performed preoperatively and postoperatively at 6 weeks, 3 months, and 6 months. The peripapillary retinal nerve fiber layer (NFL) thickness, NFL plexus capillary density (NFLP-CD) and visual field (VF) were measured overall and in 8 corresponding sectors. The low-perfusion area (LPA) was used to assess the cumulative area where local NFLP-CD was significantly below normal. At 6 months, the average IOP decreased 5.3 mmHg (P = 0.004), LPA decreased by 15% (P = 0.005), and NFLP-CD improved by 12% (P < 0.001). The NFL thickness and VF mean deviation didn’t change significantly at any time point. Among the sectors with significant preoperative NFLP-CD loss, the recovery at 6 months was greatest in sectors with minimal preoperative NFL thinning (P < 0.001). In conclusion, surgical IOP lowering may improve NFLP capillary perfusion after 6 months. The perfusion recovery tended to occur in areas with minimal NFL thinning at baseline. OCTA parameters may have potential usefulness as pharmacodynamic biomarkers for glaucoma therapy.Liang LiuHana L. TakusagawaMiles F. GreenwaldJie WangBrock AlonzoBeth EdmundsJohn C. MorrisonOu TanYali JiaDavid HuangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Liang Liu Hana L. Takusagawa Miles F. Greenwald Jie Wang Brock Alonzo Beth Edmunds John C. Morrison Ou Tan Yali Jia David Huang Optical coherence tomographic angiography study of perfusion recovery after surgical lowering of intraocular pressure
description	Abstract We investigated the time and location of retinal perfusion recovery after surgical intraocular pressure (IOP) lowering in glaucoma by using optical coherent tomography angiography (OCTA). Seventeen patients were analyzed. The 4.5 × 4.5-mm OCTA scans centered on the disc were performed preoperatively and postoperatively at 6 weeks, 3 months, and 6 months. The peripapillary retinal nerve fiber layer (NFL) thickness, NFL plexus capillary density (NFLP-CD) and visual field (VF) were measured overall and in 8 corresponding sectors. The low-perfusion area (LPA) was used to assess the cumulative area where local NFLP-CD was significantly below normal. At 6 months, the average IOP decreased 5.3 mmHg (P = 0.004), LPA decreased by 15% (P = 0.005), and NFLP-CD improved by 12% (P < 0.001). The NFL thickness and VF mean deviation didn’t change significantly at any time point. Among the sectors with significant preoperative NFLP-CD loss, the recovery at 6 months was greatest in sectors with minimal preoperative NFL thinning (P < 0.001). In conclusion, surgical IOP lowering may improve NFLP capillary perfusion after 6 months. The perfusion recovery tended to occur in areas with minimal NFL thinning at baseline. OCTA parameters may have potential usefulness as pharmacodynamic biomarkers for glaucoma therapy.
format	article
author	Liang Liu Hana L. Takusagawa Miles F. Greenwald Jie Wang Brock Alonzo Beth Edmunds John C. Morrison Ou Tan Yali Jia David Huang
author_facet	Liang Liu Hana L. Takusagawa Miles F. Greenwald Jie Wang Brock Alonzo Beth Edmunds John C. Morrison Ou Tan Yali Jia David Huang
author_sort	Liang Liu
title	Optical coherence tomographic angiography study of perfusion recovery after surgical lowering of intraocular pressure
title_short	Optical coherence tomographic angiography study of perfusion recovery after surgical lowering of intraocular pressure
title_full	Optical coherence tomographic angiography study of perfusion recovery after surgical lowering of intraocular pressure
title_fullStr	Optical coherence tomographic angiography study of perfusion recovery after surgical lowering of intraocular pressure
title_full_unstemmed	Optical coherence tomographic angiography study of perfusion recovery after surgical lowering of intraocular pressure
title_sort	optical coherence tomographic angiography study of perfusion recovery after surgical lowering of intraocular pressure
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/314b50f0398f428f929f5a10b8f8c623
work_keys_str_mv	AT liangliu opticalcoherencetomographicangiographystudyofperfusionrecoveryaftersurgicalloweringofintraocularpressure AT hanaltakusagawa opticalcoherencetomographicangiographystudyofperfusionrecoveryaftersurgicalloweringofintraocularpressure AT milesfgreenwald opticalcoherencetomographicangiographystudyofperfusionrecoveryaftersurgicalloweringofintraocularpressure AT jiewang opticalcoherencetomographicangiographystudyofperfusionrecoveryaftersurgicalloweringofintraocularpressure AT brockalonzo opticalcoherencetomographicangiographystudyofperfusionrecoveryaftersurgicalloweringofintraocularpressure AT bethedmunds opticalcoherencetomographicangiographystudyofperfusionrecoveryaftersurgicalloweringofintraocularpressure AT johncmorrison opticalcoherencetomographicangiographystudyofperfusionrecoveryaftersurgicalloweringofintraocularpressure AT outan opticalcoherencetomographicangiographystudyofperfusionrecoveryaftersurgicalloweringofintraocularpressure AT yalijia opticalcoherencetomographicangiographystudyofperfusionrecoveryaftersurgicalloweringofintraocularpressure AT davidhuang opticalcoherencetomographicangiographystudyofperfusionrecoveryaftersurgicalloweringofintraocularpressure
_version_	1718383743533580288

Optical coherence tomographic angiography study of perfusion recovery after surgical lowering of intraocular pressure

Ejemplares similares