In situ printing of mesenchymal stromal cells, by laser-assisted bioprinting, for in vivo bone regeneration applications

Abstract Bioprinting has emerged as a novel technological approach with the potential to address unsolved questions in the field of tissue engineering. We have recently shown that Laser Assisted Bioprinting (LAB), due to its unprecedented cell printing resolution and precision, is an attractive tool...

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Autores principales:	Virginie Keriquel, Hugo Oliveira, Murielle Rémy, Sophia Ziane, Samantha Delmond, Benoit Rousseau, Sylvie Rey, Sylvain Catros, Joelle Amédée, Fabien Guillemot, Jean-Christophe Fricain
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/31515092bb594a1391ad8cb290dcdc74
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spelling	oai:doaj.org-article:31515092bb594a1391ad8cb290dcdc742021-12-02T11:52:41ZIn situ printing of mesenchymal stromal cells, by laser-assisted bioprinting, for in vivo bone regeneration applications10.1038/s41598-017-01914-x2045-2322https://doaj.org/article/31515092bb594a1391ad8cb290dcdc742017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01914-xhttps://doaj.org/toc/2045-2322Abstract Bioprinting has emerged as a novel technological approach with the potential to address unsolved questions in the field of tissue engineering. We have recently shown that Laser Assisted Bioprinting (LAB), due to its unprecedented cell printing resolution and precision, is an attractive tool for the in situ printing of a bone substitute. Here, we show that LAB can be used for the in situ printing of mesenchymal stromal cells, associated with collagen and nano-hydroxyapatite, in order to favor bone regeneration, in a calvaria defect model in mice. Also, by testing different cell printing geometries, we show that different cellular arrangements impact on bone tissue regeneration. This work opens new avenues on the development of novel strategies, using in situ bioprinting, for the building of tissues, from the ground up.Virginie KeriquelHugo OliveiraMurielle RémySophia ZianeSamantha DelmondBenoit RousseauSylvie ReySylvain CatrosJoelle AmédéeFabien GuillemotJean-Christophe FricainNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Virginie Keriquel Hugo Oliveira Murielle Rémy Sophia Ziane Samantha Delmond Benoit Rousseau Sylvie Rey Sylvain Catros Joelle Amédée Fabien Guillemot Jean-Christophe Fricain In situ printing of mesenchymal stromal cells, by laser-assisted bioprinting, for in vivo bone regeneration applications
description	Abstract Bioprinting has emerged as a novel technological approach with the potential to address unsolved questions in the field of tissue engineering. We have recently shown that Laser Assisted Bioprinting (LAB), due to its unprecedented cell printing resolution and precision, is an attractive tool for the in situ printing of a bone substitute. Here, we show that LAB can be used for the in situ printing of mesenchymal stromal cells, associated with collagen and nano-hydroxyapatite, in order to favor bone regeneration, in a calvaria defect model in mice. Also, by testing different cell printing geometries, we show that different cellular arrangements impact on bone tissue regeneration. This work opens new avenues on the development of novel strategies, using in situ bioprinting, for the building of tissues, from the ground up.
format	article
author	Virginie Keriquel Hugo Oliveira Murielle Rémy Sophia Ziane Samantha Delmond Benoit Rousseau Sylvie Rey Sylvain Catros Joelle Amédée Fabien Guillemot Jean-Christophe Fricain
author_facet	Virginie Keriquel Hugo Oliveira Murielle Rémy Sophia Ziane Samantha Delmond Benoit Rousseau Sylvie Rey Sylvain Catros Joelle Amédée Fabien Guillemot Jean-Christophe Fricain
author_sort	Virginie Keriquel
title	In situ printing of mesenchymal stromal cells, by laser-assisted bioprinting, for in vivo bone regeneration applications
title_short	In situ printing of mesenchymal stromal cells, by laser-assisted bioprinting, for in vivo bone regeneration applications
title_full	In situ printing of mesenchymal stromal cells, by laser-assisted bioprinting, for in vivo bone regeneration applications
title_fullStr	In situ printing of mesenchymal stromal cells, by laser-assisted bioprinting, for in vivo bone regeneration applications
title_full_unstemmed	In situ printing of mesenchymal stromal cells, by laser-assisted bioprinting, for in vivo bone regeneration applications
title_sort	in situ printing of mesenchymal stromal cells, by laser-assisted bioprinting, for in vivo bone regeneration applications
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/31515092bb594a1391ad8cb290dcdc74
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In situ printing of mesenchymal stromal cells, by laser-assisted bioprinting, for in vivo bone regeneration applications

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