Immune microenvironment and intrinsic subtyping in hormone receptor-positive/HER2-negative breast cancer

Abstract Little is known regarding the interaction between immune microenvironment and tumor biology in hormone receptor (HR)+/HER2− breast cancer (BC). We here assess pretreatment gene-expression data from 66 HR+/HER2− early BCs from the LETLOB trial and show that non-luminal tumors (HER2-enriched,...

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Autores principales:	Gaia Griguolo, Maria Vittoria Dieci, Laia Paré, Federica Miglietta, Daniele Giulio Generali, Antonio Frassoldati, Luigi Cavanna, Giancarlo Bisagni, Federico Piacentini, Enrico Tagliafico, Katia Cagossi, Guido Ficarra, Aleix Prat, Pierfranco Conte, Valentina Guarneri
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/3153978b88de488eab2304b48b93ed3a
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spelling	oai:doaj.org-article:3153978b88de488eab2304b48b93ed3a2021-12-02T13:30:14ZImmune microenvironment and intrinsic subtyping in hormone receptor-positive/HER2-negative breast cancer10.1038/s41523-021-00223-x2374-4677https://doaj.org/article/3153978b88de488eab2304b48b93ed3a2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41523-021-00223-xhttps://doaj.org/toc/2374-4677Abstract Little is known regarding the interaction between immune microenvironment and tumor biology in hormone receptor (HR)+/HER2− breast cancer (BC). We here assess pretreatment gene-expression data from 66 HR+/HER2− early BCs from the LETLOB trial and show that non-luminal tumors (HER2-enriched, Basal-like) present higher tumor-infiltrating lymphocyte levels than luminal tumors. Moreover, significant differences in immune infiltrate composition, assessed by CIBERSORT, were observed: non-luminal tumors showed a more proinflammatory antitumor immune infiltrate composition than luminal ones.Gaia GriguoloMaria Vittoria DieciLaia ParéFederica MigliettaDaniele Giulio GeneraliAntonio FrassoldatiLuigi CavannaGiancarlo BisagniFederico PiacentiniEnrico TagliaficoKatia CagossiGuido FicarraAleix PratPierfranco ConteValentina GuarneriNature PortfolioarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Breast Cancer, Vol 7, Iss 1, Pp 1-5 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Gaia Griguolo Maria Vittoria Dieci Laia Paré Federica Miglietta Daniele Giulio Generali Antonio Frassoldati Luigi Cavanna Giancarlo Bisagni Federico Piacentini Enrico Tagliafico Katia Cagossi Guido Ficarra Aleix Prat Pierfranco Conte Valentina Guarneri Immune microenvironment and intrinsic subtyping in hormone receptor-positive/HER2-negative breast cancer
description	Abstract Little is known regarding the interaction between immune microenvironment and tumor biology in hormone receptor (HR)+/HER2− breast cancer (BC). We here assess pretreatment gene-expression data from 66 HR+/HER2− early BCs from the LETLOB trial and show that non-luminal tumors (HER2-enriched, Basal-like) present higher tumor-infiltrating lymphocyte levels than luminal tumors. Moreover, significant differences in immune infiltrate composition, assessed by CIBERSORT, were observed: non-luminal tumors showed a more proinflammatory antitumor immune infiltrate composition than luminal ones.
format	article
author	Gaia Griguolo Maria Vittoria Dieci Laia Paré Federica Miglietta Daniele Giulio Generali Antonio Frassoldati Luigi Cavanna Giancarlo Bisagni Federico Piacentini Enrico Tagliafico Katia Cagossi Guido Ficarra Aleix Prat Pierfranco Conte Valentina Guarneri
author_facet	Gaia Griguolo Maria Vittoria Dieci Laia Paré Federica Miglietta Daniele Giulio Generali Antonio Frassoldati Luigi Cavanna Giancarlo Bisagni Federico Piacentini Enrico Tagliafico Katia Cagossi Guido Ficarra Aleix Prat Pierfranco Conte Valentina Guarneri
author_sort	Gaia Griguolo
title	Immune microenvironment and intrinsic subtyping in hormone receptor-positive/HER2-negative breast cancer
title_short	Immune microenvironment and intrinsic subtyping in hormone receptor-positive/HER2-negative breast cancer
title_full	Immune microenvironment and intrinsic subtyping in hormone receptor-positive/HER2-negative breast cancer
title_fullStr	Immune microenvironment and intrinsic subtyping in hormone receptor-positive/HER2-negative breast cancer
title_full_unstemmed	Immune microenvironment and intrinsic subtyping in hormone receptor-positive/HER2-negative breast cancer
title_sort	immune microenvironment and intrinsic subtyping in hormone receptor-positive/her2-negative breast cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3153978b88de488eab2304b48b93ed3a
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Immune microenvironment and intrinsic subtyping in hormone receptor-positive/HER2-negative breast cancer

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