The effect of the COVID-19 pandemic on the epidemiology of positive blood cultures in Swiss intensive care units: a nationwide surveillance study

Abstract Background Evidence about the impact of the pandemic of COVID-19 on the incidence rates of blood cultures contaminations and bloodstream infections in intensive care units (ICUs) remains scant. The objective of this study was to investigate the nationwide epidemiology of positive blood cult...

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Autores principales:	Lauro Damonti, Andreas Kronenberg, Jonas Marschall, Philipp Jent, Rami Sommerstein, Marlieke E. A. De Kraker, Stephan Harbarth, Michael Gasser, Niccolò Buetti
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	COVID-19 ICU Bloodstream infections Blood culture contaminations Surveillance Medical emergencies. Critical care. Intensive care. First aid RC86-88.9
Acceso en línea:	https://doaj.org/article/3157ab94008b4146ae2e6f3e51d38f9a
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spelling	oai:doaj.org-article:3157ab94008b4146ae2e6f3e51d38f9a2021-11-28T12:03:48ZThe effect of the COVID-19 pandemic on the epidemiology of positive blood cultures in Swiss intensive care units: a nationwide surveillance study10.1186/s13054-021-03814-z1364-8535https://doaj.org/article/3157ab94008b4146ae2e6f3e51d38f9a2021-11-01T00:00:00Zhttps://doi.org/10.1186/s13054-021-03814-zhttps://doaj.org/toc/1364-8535Abstract Background Evidence about the impact of the pandemic of COVID-19 on the incidence rates of blood cultures contaminations and bloodstream infections in intensive care units (ICUs) remains scant. The objective of this study was to investigate the nationwide epidemiology of positive blood cultures drawn in ICUs during the first two pandemic waves of COVID-19 in Switzerland. Methods We analyzed data on positive blood cultures among ICU patients, prospectively collected through a nationwide surveillance system (ANRESIS), from March 30, 2020, to May 31, 2021, a 14-month timeframe that included a first wave of COVID-19, which affected the French and Italian-speaking regions, an interim period (summer 2020) and a second wave that affected the entire country. We used the number of ICU patient-days provided by the Swiss Federal Office of Public Health as denominator to calculate incidence rates of blood culture contaminations and bloodstream infections (ICU-BSI). Incidence rate ratios comparing the interim period with the second wave were determined by segmented Poisson regression models. Results A total of 1099 blood culture contaminations and 1616 ICU-BSIs were identified in 52 ICUs during the study. Overall, more episodes of blood culture contaminations and ICU-BSI were observed during the pandemic waves, compared to the interim period. The proportions of blood culture contaminations and ICU-BSI were positively associated with the ICU occupancy rate, which was higher during the COVID-19 waves. During the more representative second wave (versus interim period), we observed an increased incidence of blood culture contaminations (IRR 1.57, 95% CI 1.16–2.12) and ICU-BSI (IRR 1.20, 95% CI 1.03–1.39). Conclusions An increase in blood culture contaminations and ICU-BSIs was observed during the second COVID-19 pandemic wave, especially in months when the ICU burden of COVID-19 patients was high.Lauro DamontiAndreas KronenbergJonas MarschallPhilipp JentRami SommersteinMarlieke E. A. De KrakerStephan HarbarthMichael GasserNiccolò BuettiBMCarticleCOVID-19ICUBloodstream infectionsBlood culture contaminationsSurveillanceMedical emergencies. Critical care. Intensive care. First aidRC86-88.9ENCritical Care, Vol 25, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	COVID-19 ICU Bloodstream infections Blood culture contaminations Surveillance Medical emergencies. Critical care. Intensive care. First aid RC86-88.9
spellingShingle	COVID-19 ICU Bloodstream infections Blood culture contaminations Surveillance Medical emergencies. Critical care. Intensive care. First aid RC86-88.9 Lauro Damonti Andreas Kronenberg Jonas Marschall Philipp Jent Rami Sommerstein Marlieke E. A. De Kraker Stephan Harbarth Michael Gasser Niccolò Buetti The effect of the COVID-19 pandemic on the epidemiology of positive blood cultures in Swiss intensive care units: a nationwide surveillance study
description	Abstract Background Evidence about the impact of the pandemic of COVID-19 on the incidence rates of blood cultures contaminations and bloodstream infections in intensive care units (ICUs) remains scant. The objective of this study was to investigate the nationwide epidemiology of positive blood cultures drawn in ICUs during the first two pandemic waves of COVID-19 in Switzerland. Methods We analyzed data on positive blood cultures among ICU patients, prospectively collected through a nationwide surveillance system (ANRESIS), from March 30, 2020, to May 31, 2021, a 14-month timeframe that included a first wave of COVID-19, which affected the French and Italian-speaking regions, an interim period (summer 2020) and a second wave that affected the entire country. We used the number of ICU patient-days provided by the Swiss Federal Office of Public Health as denominator to calculate incidence rates of blood culture contaminations and bloodstream infections (ICU-BSI). Incidence rate ratios comparing the interim period with the second wave were determined by segmented Poisson regression models. Results A total of 1099 blood culture contaminations and 1616 ICU-BSIs were identified in 52 ICUs during the study. Overall, more episodes of blood culture contaminations and ICU-BSI were observed during the pandemic waves, compared to the interim period. The proportions of blood culture contaminations and ICU-BSI were positively associated with the ICU occupancy rate, which was higher during the COVID-19 waves. During the more representative second wave (versus interim period), we observed an increased incidence of blood culture contaminations (IRR 1.57, 95% CI 1.16–2.12) and ICU-BSI (IRR 1.20, 95% CI 1.03–1.39). Conclusions An increase in blood culture contaminations and ICU-BSIs was observed during the second COVID-19 pandemic wave, especially in months when the ICU burden of COVID-19 patients was high.
format	article
author	Lauro Damonti Andreas Kronenberg Jonas Marschall Philipp Jent Rami Sommerstein Marlieke E. A. De Kraker Stephan Harbarth Michael Gasser Niccolò Buetti
author_facet	Lauro Damonti Andreas Kronenberg Jonas Marschall Philipp Jent Rami Sommerstein Marlieke E. A. De Kraker Stephan Harbarth Michael Gasser Niccolò Buetti
author_sort	Lauro Damonti
title	The effect of the COVID-19 pandemic on the epidemiology of positive blood cultures in Swiss intensive care units: a nationwide surveillance study
title_short	The effect of the COVID-19 pandemic on the epidemiology of positive blood cultures in Swiss intensive care units: a nationwide surveillance study
title_full	The effect of the COVID-19 pandemic on the epidemiology of positive blood cultures in Swiss intensive care units: a nationwide surveillance study
title_fullStr	The effect of the COVID-19 pandemic on the epidemiology of positive blood cultures in Swiss intensive care units: a nationwide surveillance study
title_full_unstemmed	The effect of the COVID-19 pandemic on the epidemiology of positive blood cultures in Swiss intensive care units: a nationwide surveillance study
title_sort	effect of the covid-19 pandemic on the epidemiology of positive blood cultures in swiss intensive care units: a nationwide surveillance study
publisher	BMC
publishDate	2021
url	https://doaj.org/article/3157ab94008b4146ae2e6f3e51d38f9a
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The effect of the COVID-19 pandemic on the epidemiology of positive blood cultures in Swiss intensive care units: a nationwide surveillance study

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