Myofibroblast transcriptome indicates SFRP2hi fibroblast progenitors in systemic sclerosis skin

Myofibroblasts drive fibrosis in systemic sclerosis (SSc), but the cellular progenitors are unknown. Utilizing single cell RNA-sequencing, the authors show that SSc dermal myofibroblasts arise in a two-step process from SFRP2/DPP4-expressing progenitors and implicate upstream transcription factors.

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Autores principales:	Tracy Tabib, Mengqi Huang, Nina Morse, Anna Papazoglou, Rithika Behera, Minxue Jia, Melissa Bulik, Daisy E. Monier, Panayiotis V. Benos, Wei Chen, Robyn Domsic, Robert Lafyatis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/315941fe1fd14c9aa1d7eb8778f6f9fe
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spelling	oai:doaj.org-article:315941fe1fd14c9aa1d7eb8778f6f9fe2021-12-02T16:26:25ZMyofibroblast transcriptome indicates SFRP2hi fibroblast progenitors in systemic sclerosis skin10.1038/s41467-021-24607-62041-1723https://doaj.org/article/315941fe1fd14c9aa1d7eb8778f6f9fe2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24607-6https://doaj.org/toc/2041-1723Myofibroblasts drive fibrosis in systemic sclerosis (SSc), but the cellular progenitors are unknown. Utilizing single cell RNA-sequencing, the authors show that SSc dermal myofibroblasts arise in a two-step process from SFRP2/DPP4-expressing progenitors and implicate upstream transcription factors.Tracy TabibMengqi HuangNina MorseAnna PapazoglouRithika BeheraMinxue JiaMelissa BulikDaisy E. MonierPanayiotis V. BenosWei ChenRobyn DomsicRobert LafyatisNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tracy Tabib Mengqi Huang Nina Morse Anna Papazoglou Rithika Behera Minxue Jia Melissa Bulik Daisy E. Monier Panayiotis V. Benos Wei Chen Robyn Domsic Robert Lafyatis Myofibroblast transcriptome indicates SFRP2hi fibroblast progenitors in systemic sclerosis skin
description	Myofibroblasts drive fibrosis in systemic sclerosis (SSc), but the cellular progenitors are unknown. Utilizing single cell RNA-sequencing, the authors show that SSc dermal myofibroblasts arise in a two-step process from SFRP2/DPP4-expressing progenitors and implicate upstream transcription factors.
format	article
author	Tracy Tabib Mengqi Huang Nina Morse Anna Papazoglou Rithika Behera Minxue Jia Melissa Bulik Daisy E. Monier Panayiotis V. Benos Wei Chen Robyn Domsic Robert Lafyatis
author_facet	Tracy Tabib Mengqi Huang Nina Morse Anna Papazoglou Rithika Behera Minxue Jia Melissa Bulik Daisy E. Monier Panayiotis V. Benos Wei Chen Robyn Domsic Robert Lafyatis
author_sort	Tracy Tabib
title	Myofibroblast transcriptome indicates SFRP2hi fibroblast progenitors in systemic sclerosis skin
title_short	Myofibroblast transcriptome indicates SFRP2hi fibroblast progenitors in systemic sclerosis skin
title_full	Myofibroblast transcriptome indicates SFRP2hi fibroblast progenitors in systemic sclerosis skin
title_fullStr	Myofibroblast transcriptome indicates SFRP2hi fibroblast progenitors in systemic sclerosis skin
title_full_unstemmed	Myofibroblast transcriptome indicates SFRP2hi fibroblast progenitors in systemic sclerosis skin
title_sort	myofibroblast transcriptome indicates sfrp2hi fibroblast progenitors in systemic sclerosis skin
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/315941fe1fd14c9aa1d7eb8778f6f9fe
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Myofibroblast transcriptome indicates SFRP2hi fibroblast progenitors in systemic sclerosis skin

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