Harnessing supramolecular peptide nanotechnology in biomedical applications

Kiat Hwa Chan,1 Wei Hao Lee,2 Shuangmu Zhuo,3 Ming Ni3 1Division of Science, Yale-NUS College, Singapore; 2Department of Chemistry, Krieger School of Arts & Sciences, Johns Hopkins University, Baltimore, MD, USA; 3Fujian Provincial Key Laboratory for Photonics Technology, Key Laboratory of...

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Autores principales:	Chan KH, Lee WH, Zhuo S, Ni M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	peptides self-assembly nanotechnology Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/315ac2fec7dd41ebb9f1287a5c4212b8
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spelling	oai:doaj.org-article:315ac2fec7dd41ebb9f1287a5c4212b82021-12-02T02:48:59ZHarnessing supramolecular peptide nanotechnology in biomedical applications1178-2013https://doaj.org/article/315ac2fec7dd41ebb9f1287a5c4212b82017-02-01T00:00:00Zhttps://www.dovepress.com/harnessing-supramolecular-peptide-nanotechnology-in-biomedical-applica-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Kiat Hwa Chan,1 Wei Hao Lee,2 Shuangmu Zhuo,3 Ming Ni3 1Division of Science, Yale-NUS College, Singapore; 2Department of Chemistry, Krieger School of Arts & Sciences, Johns Hopkins University, Baltimore, MD, USA; 3Fujian Provincial Key Laboratory for Photonics Technology, Key Laboratory of OptoElectronic Science and Technology for Medicine of Ministry of Education, Fujian Normal University, Fuzhou, People’s Republic of China Abstract: The harnessing of peptides in biomedical applications is a recent hot topic. This arises mainly from the general biocompatibility of peptides, as well as from the ease of tunability of peptide structure to engineer desired properties. The ease of progression from laboratory testing to clinical trials is evident from the plethora of examples available. In this review, we compare and contrast how three distinct self-assembled peptide nanostructures possess different functions. We have 1) nanofibrils in biomaterials that can interact with cells, 2) nanoparticles that can traverse the bloodstream to deliver its payload and also be bioimaged, and 3) nanotubes that can serve as cross-membrane conduits and as a template for nanowire formation. Through this review, we aim to illustrate how various peptides, in their various self-assembled nanostructures, possess great promise in a wide range of biomedical applications and what more can be expected. Keywords: peptides, self-assembly, nanotechnologyChan KHLee WHZhuo SNi MDove Medical Pressarticlepeptidesself-assemblynanotechnologyMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 1171-1182 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	peptides self-assembly nanotechnology Medicine (General) R5-920
spellingShingle	peptides self-assembly nanotechnology Medicine (General) R5-920 Chan KH Lee WH Zhuo S Ni M Harnessing supramolecular peptide nanotechnology in biomedical applications
description	Kiat Hwa Chan,1 Wei Hao Lee,2 Shuangmu Zhuo,3 Ming Ni3 1Division of Science, Yale-NUS College, Singapore; 2Department of Chemistry, Krieger School of Arts & Sciences, Johns Hopkins University, Baltimore, MD, USA; 3Fujian Provincial Key Laboratory for Photonics Technology, Key Laboratory of OptoElectronic Science and Technology for Medicine of Ministry of Education, Fujian Normal University, Fuzhou, People’s Republic of China Abstract: The harnessing of peptides in biomedical applications is a recent hot topic. This arises mainly from the general biocompatibility of peptides, as well as from the ease of tunability of peptide structure to engineer desired properties. The ease of progression from laboratory testing to clinical trials is evident from the plethora of examples available. In this review, we compare and contrast how three distinct self-assembled peptide nanostructures possess different functions. We have 1) nanofibrils in biomaterials that can interact with cells, 2) nanoparticles that can traverse the bloodstream to deliver its payload and also be bioimaged, and 3) nanotubes that can serve as cross-membrane conduits and as a template for nanowire formation. Through this review, we aim to illustrate how various peptides, in their various self-assembled nanostructures, possess great promise in a wide range of biomedical applications and what more can be expected. Keywords: peptides, self-assembly, nanotechnology
format	article
author	Chan KH Lee WH Zhuo S Ni M
author_facet	Chan KH Lee WH Zhuo S Ni M
author_sort	Chan KH
title	Harnessing supramolecular peptide nanotechnology in biomedical applications
title_short	Harnessing supramolecular peptide nanotechnology in biomedical applications
title_full	Harnessing supramolecular peptide nanotechnology in biomedical applications
title_fullStr	Harnessing supramolecular peptide nanotechnology in biomedical applications
title_full_unstemmed	Harnessing supramolecular peptide nanotechnology in biomedical applications
title_sort	harnessing supramolecular peptide nanotechnology in biomedical applications
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/315ac2fec7dd41ebb9f1287a5c4212b8
work_keys_str_mv	AT chankh harnessingsupramolecularpeptidenanotechnologyinbiomedicalapplications AT leewh harnessingsupramolecularpeptidenanotechnologyinbiomedicalapplications AT zhuos harnessingsupramolecularpeptidenanotechnologyinbiomedicalapplications AT nim harnessingsupramolecularpeptidenanotechnologyinbiomedicalapplications
_version_	1718402094237483008

Harnessing supramolecular peptide nanotechnology in biomedical applications

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