Confronting false discoveries in single-cell differential expression

Differential expression analysis of single-cell transcriptomics allows scientists to dissect cell-type-specific responses to biological perturbations. Here, the authors show that many commonly used methods are biased and can produce false discoveries.

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Detalles Bibliográficos
Autores principales:	Jordan W. Squair, Matthieu Gautier, Claudia Kathe, Mark A. Anderson, Nicholas D. James, Thomas H. Hutson, Rémi Hudelle, Taha Qaiser, Kaya J. E. Matson, Quentin Barraud, Ariel J. Levine, Gioele La Manno, Michael A. Skinnider, Grégoire Courtine
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/315bac3c84574451adbbba4a10948a12
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spelling	oai:doaj.org-article:315bac3c84574451adbbba4a10948a122021-12-02T17:37:13ZConfronting false discoveries in single-cell differential expression10.1038/s41467-021-25960-22041-1723https://doaj.org/article/315bac3c84574451adbbba4a10948a122021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25960-2https://doaj.org/toc/2041-1723Differential expression analysis of single-cell transcriptomics allows scientists to dissect cell-type-specific responses to biological perturbations. Here, the authors show that many commonly used methods are biased and can produce false discoveries.Jordan W. SquairMatthieu GautierClaudia KatheMark A. AndersonNicholas D. JamesThomas H. HutsonRémi HudelleTaha QaiserKaya J. E. MatsonQuentin BarraudAriel J. LevineGioele La MannoMichael A. SkinniderGrégoire CourtineNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jordan W. Squair Matthieu Gautier Claudia Kathe Mark A. Anderson Nicholas D. James Thomas H. Hutson Rémi Hudelle Taha Qaiser Kaya J. E. Matson Quentin Barraud Ariel J. Levine Gioele La Manno Michael A. Skinnider Grégoire Courtine Confronting false discoveries in single-cell differential expression
description	Differential expression analysis of single-cell transcriptomics allows scientists to dissect cell-type-specific responses to biological perturbations. Here, the authors show that many commonly used methods are biased and can produce false discoveries.
format	article
author	Jordan W. Squair Matthieu Gautier Claudia Kathe Mark A. Anderson Nicholas D. James Thomas H. Hutson Rémi Hudelle Taha Qaiser Kaya J. E. Matson Quentin Barraud Ariel J. Levine Gioele La Manno Michael A. Skinnider Grégoire Courtine
author_facet	Jordan W. Squair Matthieu Gautier Claudia Kathe Mark A. Anderson Nicholas D. James Thomas H. Hutson Rémi Hudelle Taha Qaiser Kaya J. E. Matson Quentin Barraud Ariel J. Levine Gioele La Manno Michael A. Skinnider Grégoire Courtine
author_sort	Jordan W. Squair
title	Confronting false discoveries in single-cell differential expression
title_short	Confronting false discoveries in single-cell differential expression
title_full	Confronting false discoveries in single-cell differential expression
title_fullStr	Confronting false discoveries in single-cell differential expression
title_full_unstemmed	Confronting false discoveries in single-cell differential expression
title_sort	confronting false discoveries in single-cell differential expression
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/315bac3c84574451adbbba4a10948a12
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Confronting false discoveries in single-cell differential expression

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