Cell adhesion molecules and exercise

Yunsuk Koh,1 Jinkyung Park2 1Department of Health, Human Performance, and Recreation, Baylor University, Waco, TX, USA; 2Department of Kinesiology, George Mason University, Manassas, VA, USA Background: An extensive systematic review was undertaken in the current literature in order to explore the r...

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Autores principales:	Koh Y, Park J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	ICAM-1 VCAM-1 Endothelial dysfunction Inflammation Cardiovascular diseases Atherosclerosis Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/315bd4b4d884425abd1913c9c21f3967
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spelling	oai:doaj.org-article:315bd4b4d884425abd1913c9c21f39672021-12-02T04:48:24ZCell adhesion molecules and exercise1178-7031https://doaj.org/article/315bd4b4d884425abd1913c9c21f39672018-07-01T00:00:00Zhttps://www.dovepress.com/cell-adhesion-molecules-and-exercise-peer-reviewed-article-JIRhttps://doaj.org/toc/1178-7031Yunsuk Koh,1 Jinkyung Park2 1Department of Health, Human Performance, and Recreation, Baylor University, Waco, TX, USA; 2Department of Kinesiology, George Mason University, Manassas, VA, USA Background: An extensive systematic review was undertaken in the current literature in order to explore the role of different types and intensities of exercise in cell adhesion molecules (CAMs), one of the markers of vascular inflammation, endothelial dysfunction, and atherosclerosis. Methods: Twenty-eight qualifying studies were extensively reviewed to examine the effects of different intensities (low-to-moderate vs. high) and types (aerobic vs. resistance) of exercise on intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and selectins. Results: Low-to-moderate intensity aerobic exercise favorably decreased CAMs in a variety of subject populations, while CAMs momentarily increased immediately following high-intensity aerobic exercise, which then returned to the pre-exercise level within several hours post-exercise. Resistance exercise, regardless of its intensity, did not significantly influence CAMs. Conclusion: It is evident that the responses of CAMs are dependent upon the type and intensity of exercise performed. The most common, favorable outcome was a decrease in CAMs following low-to-moderate intensity aerobic exercise, while high-intensity aerobic exercise showed a short-lived, momentary increase in CAMs, which returned to the pre-exercise level within a few hours post-exercise. Resistance exercise, regardless of its intensity, neither significantly increased nor decreased CAMs. Future studies should focus more on the role of exercise in both soluble and membrane-bound CAMs as well as proinflammatory cytokines related to atherosclerosis in order to develop specific exercise programing that can effectively improve vascular inflammation and endothelial health. Keywords: ICAM-1, VCAM-1, endothelial dysfunction, inflammation, cardiovascular diseases, atherosclerosisKoh YPark JDove Medical PressarticleICAM-1VCAM-1Endothelial dysfunctionInflammationCardiovascular diseasesAtherosclerosisPathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 11, Pp 297-306 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	ICAM-1 VCAM-1 Endothelial dysfunction Inflammation Cardiovascular diseases Atherosclerosis Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	ICAM-1 VCAM-1 Endothelial dysfunction Inflammation Cardiovascular diseases Atherosclerosis Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Koh Y Park J Cell adhesion molecules and exercise
description	Yunsuk Koh,1 Jinkyung Park2 1Department of Health, Human Performance, and Recreation, Baylor University, Waco, TX, USA; 2Department of Kinesiology, George Mason University, Manassas, VA, USA Background: An extensive systematic review was undertaken in the current literature in order to explore the role of different types and intensities of exercise in cell adhesion molecules (CAMs), one of the markers of vascular inflammation, endothelial dysfunction, and atherosclerosis. Methods: Twenty-eight qualifying studies were extensively reviewed to examine the effects of different intensities (low-to-moderate vs. high) and types (aerobic vs. resistance) of exercise on intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and selectins. Results: Low-to-moderate intensity aerobic exercise favorably decreased CAMs in a variety of subject populations, while CAMs momentarily increased immediately following high-intensity aerobic exercise, which then returned to the pre-exercise level within several hours post-exercise. Resistance exercise, regardless of its intensity, did not significantly influence CAMs. Conclusion: It is evident that the responses of CAMs are dependent upon the type and intensity of exercise performed. The most common, favorable outcome was a decrease in CAMs following low-to-moderate intensity aerobic exercise, while high-intensity aerobic exercise showed a short-lived, momentary increase in CAMs, which returned to the pre-exercise level within a few hours post-exercise. Resistance exercise, regardless of its intensity, neither significantly increased nor decreased CAMs. Future studies should focus more on the role of exercise in both soluble and membrane-bound CAMs as well as proinflammatory cytokines related to atherosclerosis in order to develop specific exercise programing that can effectively improve vascular inflammation and endothelial health. Keywords: ICAM-1, VCAM-1, endothelial dysfunction, inflammation, cardiovascular diseases, atherosclerosis
format	article
author	Koh Y Park J
author_facet	Koh Y Park J
author_sort	Koh Y
title	Cell adhesion molecules and exercise
title_short	Cell adhesion molecules and exercise
title_full	Cell adhesion molecules and exercise
title_fullStr	Cell adhesion molecules and exercise
title_full_unstemmed	Cell adhesion molecules and exercise
title_sort	cell adhesion molecules and exercise
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/315bd4b4d884425abd1913c9c21f3967
work_keys_str_mv	AT kohy celladhesionmoleculesandexercise AT parkj celladhesionmoleculesandexercise
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Cell adhesion molecules and exercise

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