Conceptual disorganization and redistribution of resting-state cortical hubs in untreated first-episode psychosis: A 7T study

Abstract Network-level dysconnectivity has been studied in positive and negative symptoms of schizophrenia. Conceptual disorganization (CD) is a symptom subtype that predicts impaired real-world functioning in psychosis. Systematic reviews have reported aberrant connectivity in formal thought disord...

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Autores principales:	Avyarthana Dey, Kara Dempster, Michael MacKinley, Peter Jeon, Tushar Das, Ali Khan, Joe Gati, Lena Palaniyappan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Psychiatry RC435-571
Acceso en línea:	https://doaj.org/article/315f845d45e445cea4082edd32f9a210
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spelling	oai:doaj.org-article:315f845d45e445cea4082edd32f9a2102021-12-02T14:16:25ZConceptual disorganization and redistribution of resting-state cortical hubs in untreated first-episode psychosis: A 7T study10.1038/s41537-020-00130-32334-265Xhttps://doaj.org/article/315f845d45e445cea4082edd32f9a2102021-01-01T00:00:00Zhttps://doi.org/10.1038/s41537-020-00130-3https://doaj.org/toc/2334-265XAbstract Network-level dysconnectivity has been studied in positive and negative symptoms of schizophrenia. Conceptual disorganization (CD) is a symptom subtype that predicts impaired real-world functioning in psychosis. Systematic reviews have reported aberrant connectivity in formal thought disorder, a construct related to CD. However, no studies have investigated whole-brain functional correlates of CD in psychosis. We sought to investigate brain regions explaining the severity of CD in patients with first-episode psychosis (FEPs) compared with healthy controls (HCs). We computed whole-brain binarized degree centrality maps of 31 FEPs, 25 HCs, and characterized the patterns of network connectivity in the 2 groups. In FEPs, we related these findings to the severity of CD. We also studied the effect of positive and negative symptoms on altered network connectivity. Compared to HCs, reduced centrality of a right superior temporal gyrus (rSTG) cluster was observed in the FEPs. In patients exhibiting high CD, increased centrality of a medial superior parietal (mSPL) cluster was observed, compared to patients exhibiting low CD. This cluster was strongly correlated with CD scores but not with other symptom scores. Our observations are congruent with previous findings of reduced but not increased centrality. We observed increased centrality of mSPL suggesting that cortical reorganization occurs to provide alternate routes for information transfer. These findings provide insight into the underlying neural processes mediating the presentation of symptoms in untreated FEP. Longitudinal tracking of the symptom course will be useful to assess the mechanisms underlying these compensatory changes.Avyarthana DeyKara DempsterMichael MacKinleyPeter JeonTushar DasAli KhanJoe GatiLena PalaniyappanNature PortfolioarticlePsychiatryRC435-571ENnpj Schizophrenia, Vol 7, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Psychiatry RC435-571
spellingShingle	Psychiatry RC435-571 Avyarthana Dey Kara Dempster Michael MacKinley Peter Jeon Tushar Das Ali Khan Joe Gati Lena Palaniyappan Conceptual disorganization and redistribution of resting-state cortical hubs in untreated first-episode psychosis: A 7T study
description	Abstract Network-level dysconnectivity has been studied in positive and negative symptoms of schizophrenia. Conceptual disorganization (CD) is a symptom subtype that predicts impaired real-world functioning in psychosis. Systematic reviews have reported aberrant connectivity in formal thought disorder, a construct related to CD. However, no studies have investigated whole-brain functional correlates of CD in psychosis. We sought to investigate brain regions explaining the severity of CD in patients with first-episode psychosis (FEPs) compared with healthy controls (HCs). We computed whole-brain binarized degree centrality maps of 31 FEPs, 25 HCs, and characterized the patterns of network connectivity in the 2 groups. In FEPs, we related these findings to the severity of CD. We also studied the effect of positive and negative symptoms on altered network connectivity. Compared to HCs, reduced centrality of a right superior temporal gyrus (rSTG) cluster was observed in the FEPs. In patients exhibiting high CD, increased centrality of a medial superior parietal (mSPL) cluster was observed, compared to patients exhibiting low CD. This cluster was strongly correlated with CD scores but not with other symptom scores. Our observations are congruent with previous findings of reduced but not increased centrality. We observed increased centrality of mSPL suggesting that cortical reorganization occurs to provide alternate routes for information transfer. These findings provide insight into the underlying neural processes mediating the presentation of symptoms in untreated FEP. Longitudinal tracking of the symptom course will be useful to assess the mechanisms underlying these compensatory changes.
format	article
author	Avyarthana Dey Kara Dempster Michael MacKinley Peter Jeon Tushar Das Ali Khan Joe Gati Lena Palaniyappan
author_facet	Avyarthana Dey Kara Dempster Michael MacKinley Peter Jeon Tushar Das Ali Khan Joe Gati Lena Palaniyappan
author_sort	Avyarthana Dey
title	Conceptual disorganization and redistribution of resting-state cortical hubs in untreated first-episode psychosis: A 7T study
title_short	Conceptual disorganization and redistribution of resting-state cortical hubs in untreated first-episode psychosis: A 7T study
title_full	Conceptual disorganization and redistribution of resting-state cortical hubs in untreated first-episode psychosis: A 7T study
title_fullStr	Conceptual disorganization and redistribution of resting-state cortical hubs in untreated first-episode psychosis: A 7T study
title_full_unstemmed	Conceptual disorganization and redistribution of resting-state cortical hubs in untreated first-episode psychosis: A 7T study
title_sort	conceptual disorganization and redistribution of resting-state cortical hubs in untreated first-episode psychosis: a 7t study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/315f845d45e445cea4082edd32f9a210
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Conceptual disorganization and redistribution of resting-state cortical hubs in untreated first-episode psychosis: A 7T study

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