Evaluation of antidepressant activities of Rose oil and Geranium oil in the mouse forced swim test

Background and Objective: Depression is one of the most common psychiatric disorders that results in significant consequences in active population of the society. In traditional manuscripts, there are many indications about the anti-depressant effects of Rose oil. The purpose of this study was to de...

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Autores principales:	D Farzin, M Zarghami, L Khalaj
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2005
Materias:	depression forced swim test rose oil geranium oil mouse Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/3161bb98f532447e9ec5e6322b162be1
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spelling	oai:doaj.org-article:3161bb98f532447e9ec5e6322b162be12021-11-10T09:14:24ZEvaluation of antidepressant activities of Rose oil and Geranium oil in the mouse forced swim test1561-41072251-7170https://doaj.org/article/3161bb98f532447e9ec5e6322b162be12005-01-01T00:00:00Zhttp://jbums.org/article-1-2646-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170Background and Objective: Depression is one of the most common psychiatric disorders that results in significant consequences in active population of the society. In traditional manuscripts, there are many indications about the anti-depressant effects of Rose oil. The purpose of this study was to determine the anti-depressant effects of Rose oil and Geranium oil. Methods: All experiments were carried out on male Swiss-Webster mice (25-30 gr). The anti-depressant activities of Rose oil and Geranium oil were assessed using the forced swim test. In this test, mice were placed into a cylindrical glass (25 cm height, 12 cm in diameter) containing a column of 17 cm of water at 25±1°C. After 30 min (For the injection route) or 2 weeks (For the oral route) of the Rose oil and Geranium oil administrations, the mice were subjected to forced swimming test for 8 min. Findings: Acute subcutaneous (SC) injection or chronic oral administration of Rose oil and Geranium oil significantly decreased the immobility time in the mouse forced swim test. The Geranium oil response was biphasic. Pre-treatment of animals with amphetamine and nortryptiline also reduced the immobility time. The inhibitory effects elicited by Rose oil, Geranium oil and amphetamine but not nortryptiline were antagonized by reserpine. Conclusion: The results suggest that the anti-depressant activities of Rose oil and Geranium oil may be mediated through a pre-synaptic mechanism.D FarzinM ZarghamiL KhalajBabol University of Medical Sciencesarticledepressionforced swim testrose oilgeranium oilmouseMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 7, Iss 1, Pp 7-13 (2005)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	depression forced swim test rose oil geranium oil mouse Medicine R Medicine (General) R5-920
spellingShingle	depression forced swim test rose oil geranium oil mouse Medicine R Medicine (General) R5-920 D Farzin M Zarghami L Khalaj Evaluation of antidepressant activities of Rose oil and Geranium oil in the mouse forced swim test
description	Background and Objective: Depression is one of the most common psychiatric disorders that results in significant consequences in active population of the society. In traditional manuscripts, there are many indications about the anti-depressant effects of Rose oil. The purpose of this study was to determine the anti-depressant effects of Rose oil and Geranium oil. Methods: All experiments were carried out on male Swiss-Webster mice (25-30 gr). The anti-depressant activities of Rose oil and Geranium oil were assessed using the forced swim test. In this test, mice were placed into a cylindrical glass (25 cm height, 12 cm in diameter) containing a column of 17 cm of water at 25±1°C. After 30 min (For the injection route) or 2 weeks (For the oral route) of the Rose oil and Geranium oil administrations, the mice were subjected to forced swimming test for 8 min. Findings: Acute subcutaneous (SC) injection or chronic oral administration of Rose oil and Geranium oil significantly decreased the immobility time in the mouse forced swim test. The Geranium oil response was biphasic. Pre-treatment of animals with amphetamine and nortryptiline also reduced the immobility time. The inhibitory effects elicited by Rose oil, Geranium oil and amphetamine but not nortryptiline were antagonized by reserpine. Conclusion: The results suggest that the anti-depressant activities of Rose oil and Geranium oil may be mediated through a pre-synaptic mechanism.
format	article
author	D Farzin M Zarghami L Khalaj
author_facet	D Farzin M Zarghami L Khalaj
author_sort	D Farzin
title	Evaluation of antidepressant activities of Rose oil and Geranium oil in the mouse forced swim test
title_short	Evaluation of antidepressant activities of Rose oil and Geranium oil in the mouse forced swim test
title_full	Evaluation of antidepressant activities of Rose oil and Geranium oil in the mouse forced swim test
title_fullStr	Evaluation of antidepressant activities of Rose oil and Geranium oil in the mouse forced swim test
title_full_unstemmed	Evaluation of antidepressant activities of Rose oil and Geranium oil in the mouse forced swim test
title_sort	evaluation of antidepressant activities of rose oil and geranium oil in the mouse forced swim test
publisher	Babol University of Medical Sciences
publishDate	2005
url	https://doaj.org/article/3161bb98f532447e9ec5e6322b162be1
work_keys_str_mv	AT dfarzin evaluationofantidepressantactivitiesofroseoilandgeraniumoilinthemouseforcedswimtest AT mzarghami evaluationofantidepressantactivitiesofroseoilandgeraniumoilinthemouseforcedswimtest AT lkhalaj evaluationofantidepressantactivitiesofroseoilandgeraniumoilinthemouseforcedswimtest
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Evaluation of antidepressant activities of Rose oil and Geranium oil in the mouse forced swim test

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