A neuronal mechanism underlying decision-making deficits during hyperdopaminergic states

Aberrant increased dopaminergic function results in impaired value-based decision making. Here the authors report pathway-specific effects of VTA activation on distinct aspects of flexible value-based decisions in rats.

Guardado en:

Detalles Bibliográficos
Autores principales:	Jeroen P. H. Verharen, Johannes W. de Jong, Theresia J. M. Roelofs, Christiaan F. M. Huffels, Ruud van Zessen, Mieneke C. M. Luijendijk, Ralph Hamelink, Ingo Willuhn, Hanneke E. M. den Ouden, Geoffrey van der Plasse, Roger A. H. Adan, Louk J. M. J. Vanderschuren
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/31622733c1f8444ca230c79f49f730a9
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:31622733c1f8444ca230c79f49f730a9
record_format	dspace
spelling	oai:doaj.org-article:31622733c1f8444ca230c79f49f730a92021-12-02T17:32:03ZA neuronal mechanism underlying decision-making deficits during hyperdopaminergic states10.1038/s41467-018-03087-12041-1723https://doaj.org/article/31622733c1f8444ca230c79f49f730a92018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03087-1https://doaj.org/toc/2041-1723Aberrant increased dopaminergic function results in impaired value-based decision making. Here the authors report pathway-specific effects of VTA activation on distinct aspects of flexible value-based decisions in rats.Jeroen P. H. VerharenJohannes W. de JongTheresia J. M. RoelofsChristiaan F. M. HuffelsRuud van ZessenMieneke C. M. LuijendijkRalph HamelinkIngo WilluhnHanneke E. M. den OudenGeoffrey van der PlasseRoger A. H. AdanLouk J. M. J. VanderschurenNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jeroen P. H. Verharen Johannes W. de Jong Theresia J. M. Roelofs Christiaan F. M. Huffels Ruud van Zessen Mieneke C. M. Luijendijk Ralph Hamelink Ingo Willuhn Hanneke E. M. den Ouden Geoffrey van der Plasse Roger A. H. Adan Louk J. M. J. Vanderschuren A neuronal mechanism underlying decision-making deficits during hyperdopaminergic states
description	Aberrant increased dopaminergic function results in impaired value-based decision making. Here the authors report pathway-specific effects of VTA activation on distinct aspects of flexible value-based decisions in rats.
format	article
author	Jeroen P. H. Verharen Johannes W. de Jong Theresia J. M. Roelofs Christiaan F. M. Huffels Ruud van Zessen Mieneke C. M. Luijendijk Ralph Hamelink Ingo Willuhn Hanneke E. M. den Ouden Geoffrey van der Plasse Roger A. H. Adan Louk J. M. J. Vanderschuren
author_facet	Jeroen P. H. Verharen Johannes W. de Jong Theresia J. M. Roelofs Christiaan F. M. Huffels Ruud van Zessen Mieneke C. M. Luijendijk Ralph Hamelink Ingo Willuhn Hanneke E. M. den Ouden Geoffrey van der Plasse Roger A. H. Adan Louk J. M. J. Vanderschuren
author_sort	Jeroen P. H. Verharen
title	A neuronal mechanism underlying decision-making deficits during hyperdopaminergic states
title_short	A neuronal mechanism underlying decision-making deficits during hyperdopaminergic states
title_full	A neuronal mechanism underlying decision-making deficits during hyperdopaminergic states
title_fullStr	A neuronal mechanism underlying decision-making deficits during hyperdopaminergic states
title_full_unstemmed	A neuronal mechanism underlying decision-making deficits during hyperdopaminergic states
title_sort	neuronal mechanism underlying decision-making deficits during hyperdopaminergic states
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/31622733c1f8444ca230c79f49f730a9
work_keys_str_mv	AT jeroenphverharen aneuronalmechanismunderlyingdecisionmakingdeficitsduringhyperdopaminergicstates AT johanneswdejong aneuronalmechanismunderlyingdecisionmakingdeficitsduringhyperdopaminergicstates AT theresiajmroelofs aneuronalmechanismunderlyingdecisionmakingdeficitsduringhyperdopaminergicstates AT christiaanfmhuffels aneuronalmechanismunderlyingdecisionmakingdeficitsduringhyperdopaminergicstates AT ruudvanzessen aneuronalmechanismunderlyingdecisionmakingdeficitsduringhyperdopaminergicstates AT mienekecmluijendijk aneuronalmechanismunderlyingdecisionmakingdeficitsduringhyperdopaminergicstates AT ralphhamelink aneuronalmechanismunderlyingdecisionmakingdeficitsduringhyperdopaminergicstates AT ingowilluhn aneuronalmechanismunderlyingdecisionmakingdeficitsduringhyperdopaminergicstates AT hannekeemdenouden aneuronalmechanismunderlyingdecisionmakingdeficitsduringhyperdopaminergicstates AT geoffreyvanderplasse aneuronalmechanismunderlyingdecisionmakingdeficitsduringhyperdopaminergicstates AT rogerahadan aneuronalmechanismunderlyingdecisionmakingdeficitsduringhyperdopaminergicstates AT loukjmjvanderschuren aneuronalmechanismunderlyingdecisionmakingdeficitsduringhyperdopaminergicstates AT jeroenphverharen neuronalmechanismunderlyingdecisionmakingdeficitsduringhyperdopaminergicstates AT johanneswdejong neuronalmechanismunderlyingdecisionmakingdeficitsduringhyperdopaminergicstates AT theresiajmroelofs neuronalmechanismunderlyingdecisionmakingdeficitsduringhyperdopaminergicstates AT christiaanfmhuffels neuronalmechanismunderlyingdecisionmakingdeficitsduringhyperdopaminergicstates AT ruudvanzessen neuronalmechanismunderlyingdecisionmakingdeficitsduringhyperdopaminergicstates AT mienekecmluijendijk neuronalmechanismunderlyingdecisionmakingdeficitsduringhyperdopaminergicstates AT ralphhamelink neuronalmechanismunderlyingdecisionmakingdeficitsduringhyperdopaminergicstates AT ingowilluhn neuronalmechanismunderlyingdecisionmakingdeficitsduringhyperdopaminergicstates AT hannekeemdenouden neuronalmechanismunderlyingdecisionmakingdeficitsduringhyperdopaminergicstates AT geoffreyvanderplasse neuronalmechanismunderlyingdecisionmakingdeficitsduringhyperdopaminergicstates AT rogerahadan neuronalmechanismunderlyingdecisionmakingdeficitsduringhyperdopaminergicstates AT loukjmjvanderschuren neuronalmechanismunderlyingdecisionmakingdeficitsduringhyperdopaminergicstates
_version_	1718380421075435520

A neuronal mechanism underlying decision-making deficits during hyperdopaminergic states

Ejemplares similares