Primary plasma cell leukemia: consensus definition by the International Myeloma Working Group according to peripheral blood plasma cell percentage

Abstract Primary plasma cell leukemia (PCL) has a consistently ominous prognosis, even after progress in the last decades. PCL deserves a prompt identification to start the most effective treatment for this ultra-high-risk disease. The aim of this position paper is to revisit the diagnosis of PCL ac...

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Autores principales:	Carlos Fernández de Larrea, Robert Kyle, Laura Rosiñol, Bruno Paiva, Monika Engelhardt, Saad Usmani, Jo Caers, Wilson Gonsalves, Fredrik Schjesvold, Giampaolo Merlini, Suzanne Lentzch, Enrique Ocio, Laurent Garderet, Philippe Moreau, Pieter Sonneveld, Ashraf Badros, Gösta Gahrton, Hartmut Goldschmidt, Sascha Tuchman, Hermann Einsele, Brian Durie, Baldeep Wirk, Pellegrino Musto, Patrick Hayden, Martin Kaiser, Jesús San Miguel, Joan Bladé, S. Vincent Rajkumar, Maria Victoria Mateos
Formato:	article
Lenguaje:	EN
Publicado:	Nature Publishing Group 2021
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/316690c0ce52472eb67f8eef3f9e74a5
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spelling	oai:doaj.org-article:316690c0ce52472eb67f8eef3f9e74a52021-12-05T12:25:49ZPrimary plasma cell leukemia: consensus definition by the International Myeloma Working Group according to peripheral blood plasma cell percentage10.1038/s41408-021-00587-02044-5385https://doaj.org/article/316690c0ce52472eb67f8eef3f9e74a52021-12-01T00:00:00Zhttps://doi.org/10.1038/s41408-021-00587-0https://doaj.org/toc/2044-5385Abstract Primary plasma cell leukemia (PCL) has a consistently ominous prognosis, even after progress in the last decades. PCL deserves a prompt identification to start the most effective treatment for this ultra-high-risk disease. The aim of this position paper is to revisit the diagnosis of PCL according to the presence of circulating plasma cells in patients otherwise meeting diagnostic criteria of multiple myeloma. We could identify two retrospective series where the question about what number of circulating plasma cells in peripheral blood should be used for defining PCL. The presence of ≥5% circulating plasma cells in patients with MM had a similar adverse prognostic impact as the previously defined PCL. Therefore, PCL should be defined by the presence of 5% or more circulating plasma cells in peripheral blood smears in patients otherwise diagnosed with symptomatic multiple myeloma.Carlos Fernández de LarreaRobert KyleLaura RosiñolBruno PaivaMonika EngelhardtSaad UsmaniJo CaersWilson GonsalvesFredrik SchjesvoldGiampaolo MerliniSuzanne LentzchEnrique OcioLaurent GarderetPhilippe MoreauPieter SonneveldAshraf BadrosGösta GahrtonHartmut GoldschmidtSascha TuchmanHermann EinseleBrian DurieBaldeep WirkPellegrino MustoPatrick HaydenMartin KaiserJesús San MiguelJoan BladéS. Vincent RajkumarMaria Victoria MateosNature Publishing GrouparticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENBlood Cancer Journal, Vol 11, Iss 12, Pp 1-5 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Carlos Fernández de Larrea Robert Kyle Laura Rosiñol Bruno Paiva Monika Engelhardt Saad Usmani Jo Caers Wilson Gonsalves Fredrik Schjesvold Giampaolo Merlini Suzanne Lentzch Enrique Ocio Laurent Garderet Philippe Moreau Pieter Sonneveld Ashraf Badros Gösta Gahrton Hartmut Goldschmidt Sascha Tuchman Hermann Einsele Brian Durie Baldeep Wirk Pellegrino Musto Patrick Hayden Martin Kaiser Jesús San Miguel Joan Bladé S. Vincent Rajkumar Maria Victoria Mateos Primary plasma cell leukemia: consensus definition by the International Myeloma Working Group according to peripheral blood plasma cell percentage
description	Abstract Primary plasma cell leukemia (PCL) has a consistently ominous prognosis, even after progress in the last decades. PCL deserves a prompt identification to start the most effective treatment for this ultra-high-risk disease. The aim of this position paper is to revisit the diagnosis of PCL according to the presence of circulating plasma cells in patients otherwise meeting diagnostic criteria of multiple myeloma. We could identify two retrospective series where the question about what number of circulating plasma cells in peripheral blood should be used for defining PCL. The presence of ≥5% circulating plasma cells in patients with MM had a similar adverse prognostic impact as the previously defined PCL. Therefore, PCL should be defined by the presence of 5% or more circulating plasma cells in peripheral blood smears in patients otherwise diagnosed with symptomatic multiple myeloma.
format	article
author	Carlos Fernández de Larrea Robert Kyle Laura Rosiñol Bruno Paiva Monika Engelhardt Saad Usmani Jo Caers Wilson Gonsalves Fredrik Schjesvold Giampaolo Merlini Suzanne Lentzch Enrique Ocio Laurent Garderet Philippe Moreau Pieter Sonneveld Ashraf Badros Gösta Gahrton Hartmut Goldschmidt Sascha Tuchman Hermann Einsele Brian Durie Baldeep Wirk Pellegrino Musto Patrick Hayden Martin Kaiser Jesús San Miguel Joan Bladé S. Vincent Rajkumar Maria Victoria Mateos
author_facet	Carlos Fernández de Larrea Robert Kyle Laura Rosiñol Bruno Paiva Monika Engelhardt Saad Usmani Jo Caers Wilson Gonsalves Fredrik Schjesvold Giampaolo Merlini Suzanne Lentzch Enrique Ocio Laurent Garderet Philippe Moreau Pieter Sonneveld Ashraf Badros Gösta Gahrton Hartmut Goldschmidt Sascha Tuchman Hermann Einsele Brian Durie Baldeep Wirk Pellegrino Musto Patrick Hayden Martin Kaiser Jesús San Miguel Joan Bladé S. Vincent Rajkumar Maria Victoria Mateos
author_sort	Carlos Fernández de Larrea
title	Primary plasma cell leukemia: consensus definition by the International Myeloma Working Group according to peripheral blood plasma cell percentage
title_short	Primary plasma cell leukemia: consensus definition by the International Myeloma Working Group according to peripheral blood plasma cell percentage
title_full	Primary plasma cell leukemia: consensus definition by the International Myeloma Working Group according to peripheral blood plasma cell percentage
title_fullStr	Primary plasma cell leukemia: consensus definition by the International Myeloma Working Group according to peripheral blood plasma cell percentage
title_full_unstemmed	Primary plasma cell leukemia: consensus definition by the International Myeloma Working Group according to peripheral blood plasma cell percentage
title_sort	primary plasma cell leukemia: consensus definition by the international myeloma working group according to peripheral blood plasma cell percentage
publisher	Nature Publishing Group
publishDate	2021
url	https://doaj.org/article/316690c0ce52472eb67f8eef3f9e74a5
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Primary plasma cell leukemia: consensus definition by the International Myeloma Working Group according to peripheral blood plasma cell percentage

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