Potential and problems in ultrasound-responsive drug delivery systems

Ying-Zheng Zhao,1,3 Li-Na Du,2 Cui-Tao Lu,1 Yi-Guang Jin,2 Shu-Ping Ge3 1Wenzhou Medical College, Wenzhou City, Zhejiang Province, 2Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing, People’s Republic of China; 3St Christopher’s Hospital for...

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Autores principales:	Zhao YZ, Du LN, Lu CT, Jin YG, Ge SP
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/316f4b08d2384eeeab6a55774dab2281
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spelling	oai:doaj.org-article:316f4b08d2384eeeab6a55774dab22812021-12-02T07:21:42ZPotential and problems in ultrasound-responsive drug delivery systems1176-91141178-2013https://doaj.org/article/316f4b08d2384eeeab6a55774dab22812013-04-01T00:00:00Zhttp://www.dovepress.com/potential-and-problems-in-ultrasound-responsive-drug-delivery-systems-a12845https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Ying-Zheng Zhao,1,3 Li-Na Du,2 Cui-Tao Lu,1 Yi-Guang Jin,2 Shu-Ping Ge3 1Wenzhou Medical College, Wenzhou City, Zhejiang Province, 2Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing, People’s Republic of China; 3St Christopher’s Hospital for Children/Drexel University College of Medicine, Philadelphia, PA, USA Abstract: Ultrasound is an important local stimulus for triggering drug release at the target tissue. Ultrasound-responsive drug delivery systems (URDDS) have become an important research focus in targeted therapy. URDDS include many different formulations, such as microbubbles, nanobubbles, nanodroplets, liposomes, emulsions, and micelles. Drugs that can be loaded into URDDS include small molecules, biomacromolecules, and inorganic substances. Fields of clinical application include anticancer therapy, treatment of ischemic myocardium, induction of an immune response, cartilage tissue engineering, transdermal drug delivery, treatment of Huntington’s disease, thrombolysis, and disruption of the blood–brain barrier. This review focuses on recent advances in URDDS, and discusses their formulations, clinical application, and problems, as well as a perspective on their potential use in the future. Keywords: ultrasound, targeted therapy, clinical applicationZhao YZDu LNLu CTJin YGGe SPDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2013, Iss default, Pp 1621-1633 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Zhao YZ Du LN Lu CT Jin YG Ge SP Potential and problems in ultrasound-responsive drug delivery systems
description	Ying-Zheng Zhao,1,3 Li-Na Du,2 Cui-Tao Lu,1 Yi-Guang Jin,2 Shu-Ping Ge3 1Wenzhou Medical College, Wenzhou City, Zhejiang Province, 2Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing, People’s Republic of China; 3St Christopher’s Hospital for Children/Drexel University College of Medicine, Philadelphia, PA, USA Abstract: Ultrasound is an important local stimulus for triggering drug release at the target tissue. Ultrasound-responsive drug delivery systems (URDDS) have become an important research focus in targeted therapy. URDDS include many different formulations, such as microbubbles, nanobubbles, nanodroplets, liposomes, emulsions, and micelles. Drugs that can be loaded into URDDS include small molecules, biomacromolecules, and inorganic substances. Fields of clinical application include anticancer therapy, treatment of ischemic myocardium, induction of an immune response, cartilage tissue engineering, transdermal drug delivery, treatment of Huntington’s disease, thrombolysis, and disruption of the blood–brain barrier. This review focuses on recent advances in URDDS, and discusses their formulations, clinical application, and problems, as well as a perspective on their potential use in the future. Keywords: ultrasound, targeted therapy, clinical application
format	article
author	Zhao YZ Du LN Lu CT Jin YG Ge SP
author_facet	Zhao YZ Du LN Lu CT Jin YG Ge SP
author_sort	Zhao YZ
title	Potential and problems in ultrasound-responsive drug delivery systems
title_short	Potential and problems in ultrasound-responsive drug delivery systems
title_full	Potential and problems in ultrasound-responsive drug delivery systems
title_fullStr	Potential and problems in ultrasound-responsive drug delivery systems
title_full_unstemmed	Potential and problems in ultrasound-responsive drug delivery systems
title_sort	potential and problems in ultrasound-responsive drug delivery systems
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/316f4b08d2384eeeab6a55774dab2281
work_keys_str_mv	AT zhaoyz potentialandproblemsinultrasoundresponsivedrugdeliverysystems AT duln potentialandproblemsinultrasoundresponsivedrugdeliverysystems AT luct potentialandproblemsinultrasoundresponsivedrugdeliverysystems AT jinyg potentialandproblemsinultrasoundresponsivedrugdeliverysystems AT gesp potentialandproblemsinultrasoundresponsivedrugdeliverysystems
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Potential and problems in ultrasound-responsive drug delivery systems

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