Chronic stable angina is associated with lower health-related quality of life: evidence from Chinese patients.

<h4>Objectives</h4>To compare health-related quality of life (HRQoL) between patients with stable angina and the general population in China and to examine factors associated with HRQoL among patients with stable angina.<h4>Methods</h4>A cross-sectional HRQoL survey of stable...

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Autores principales:	Jing Wu, Yuerong Han, Judy Xu, Yang Lu, Hongliang Cong, Junyi Zheng, He Sun
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/317062fced594cb1b4030222862b5b78
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spelling	oai:doaj.org-article:317062fced594cb1b4030222862b5b782021-11-18T08:18:42ZChronic stable angina is associated with lower health-related quality of life: evidence from Chinese patients.1932-620310.1371/journal.pone.0097294https://doaj.org/article/317062fced594cb1b4030222862b5b782014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24842793/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objectives</h4>To compare health-related quality of life (HRQoL) between patients with stable angina and the general population in China and to examine factors associated with HRQoL among patients with stable angina.<h4>Methods</h4>A cross-sectional HRQoL survey of stable angina patients recruited from 4 hospitals (n = 411) and the general population recruited from 3 Physical Examination Centers (n = 549) was conducted from July to December, 2011 in two large cities, Tianjin and Chengdu. HRQoL was assessed using the EQ-5D, EQ-VAS, and SF-6D instruments. The health status specific to patients with stable angina was assessed using the Seattle Angina Questionnaire (SAQ). Information on socio-demographic, clinical, and lifestyle factors were also collected. Nested regressions were performed to explore how these factors were associated with HRQoL in patients with stable angina.<h4>Results</h4>Compared with the general population (44.2 ± 10 years, 49.9% females), stable angina patients (68.1 ± 12 years, 50.4% females) had significantly lower HRQoL scores in EQ-5D utility index (0.75 ± 0.19 vs. 0.90 ± 0.20, p<0.05), SF-6D utility index (0.68 ± 0.12 vs. 0.85 ± 0.11, p<0.05), and EQ-VAS (71.2 ± 12.3 vs. 83.9 ± 10.9, p<0.05). The differences remained (-0.05 for EQ-5D, -9.27 for EQ-VAS and -0.13 for SF-6D) after controlling for socio-economic characteristics. SAQ scores showed that stable angina patients experienced impaired disease-specific health status, especially in angina stability (40.5 ± 34.6). Nested regressions indicated stable angina-specific health status explained most of the variation in HRQoL, among which disease perception, physical limitation, and angina stability were the strongest predictors. More physical exercise and better sleep were positively related with HRQoL.<h4>Conclusions</h4>Compared to the general population, stable angina patients were associated with lower HRQoL and lower health utility scores, which were largely impacted by clinical symptoms. Further studies are needed to characterize the influence of geographic and cultural factors on the variations of health-related utility in stable angina patients.Jing WuYuerong HanJudy XuYang LuHongliang CongJunyi ZhengHe SunPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 5, p e97294 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jing Wu Yuerong Han Judy Xu Yang Lu Hongliang Cong Junyi Zheng He Sun Chronic stable angina is associated with lower health-related quality of life: evidence from Chinese patients.
description	<h4>Objectives</h4>To compare health-related quality of life (HRQoL) between patients with stable angina and the general population in China and to examine factors associated with HRQoL among patients with stable angina.<h4>Methods</h4>A cross-sectional HRQoL survey of stable angina patients recruited from 4 hospitals (n = 411) and the general population recruited from 3 Physical Examination Centers (n = 549) was conducted from July to December, 2011 in two large cities, Tianjin and Chengdu. HRQoL was assessed using the EQ-5D, EQ-VAS, and SF-6D instruments. The health status specific to patients with stable angina was assessed using the Seattle Angina Questionnaire (SAQ). Information on socio-demographic, clinical, and lifestyle factors were also collected. Nested regressions were performed to explore how these factors were associated with HRQoL in patients with stable angina.<h4>Results</h4>Compared with the general population (44.2 ± 10 years, 49.9% females), stable angina patients (68.1 ± 12 years, 50.4% females) had significantly lower HRQoL scores in EQ-5D utility index (0.75 ± 0.19 vs. 0.90 ± 0.20, p<0.05), SF-6D utility index (0.68 ± 0.12 vs. 0.85 ± 0.11, p<0.05), and EQ-VAS (71.2 ± 12.3 vs. 83.9 ± 10.9, p<0.05). The differences remained (-0.05 for EQ-5D, -9.27 for EQ-VAS and -0.13 for SF-6D) after controlling for socio-economic characteristics. SAQ scores showed that stable angina patients experienced impaired disease-specific health status, especially in angina stability (40.5 ± 34.6). Nested regressions indicated stable angina-specific health status explained most of the variation in HRQoL, among which disease perception, physical limitation, and angina stability were the strongest predictors. More physical exercise and better sleep were positively related with HRQoL.<h4>Conclusions</h4>Compared to the general population, stable angina patients were associated with lower HRQoL and lower health utility scores, which were largely impacted by clinical symptoms. Further studies are needed to characterize the influence of geographic and cultural factors on the variations of health-related utility in stable angina patients.
format	article
author	Jing Wu Yuerong Han Judy Xu Yang Lu Hongliang Cong Junyi Zheng He Sun
author_facet	Jing Wu Yuerong Han Judy Xu Yang Lu Hongliang Cong Junyi Zheng He Sun
author_sort	Jing Wu
title	Chronic stable angina is associated with lower health-related quality of life: evidence from Chinese patients.
title_short	Chronic stable angina is associated with lower health-related quality of life: evidence from Chinese patients.
title_full	Chronic stable angina is associated with lower health-related quality of life: evidence from Chinese patients.
title_fullStr	Chronic stable angina is associated with lower health-related quality of life: evidence from Chinese patients.
title_full_unstemmed	Chronic stable angina is associated with lower health-related quality of life: evidence from Chinese patients.
title_sort	chronic stable angina is associated with lower health-related quality of life: evidence from chinese patients.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/317062fced594cb1b4030222862b5b78
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Chronic stable angina is associated with lower health-related quality of life: evidence from Chinese patients.

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