Emerging Role of Non-Coding RNAs in Regulation of T-Lymphocyte Function

T-lymphocytes (T cells) play a major role in adaptive immunity and current immune checkpoint inhibitor-based cancer treatments. The regulation of their function is complex, and in addition to cytokines, receptors and transcription factors, several non-coding RNAs (ncRNAs) have been shown to affect d...

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Autores principales:	Mohammad Taheri, Dominik A. Barth, Julia Kargl, Omidvar Rezaei, Soudeh Ghafouri-Fard, Martin Pichler
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	miRNA lncRNA circRNA T cell cancer autoimmune Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/31713c80918a4bdc9d96b2bb322438e8
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spelling	oai:doaj.org-article:31713c80918a4bdc9d96b2bb322438e82021-11-04T06:41:02ZEmerging Role of Non-Coding RNAs in Regulation of T-Lymphocyte Function1664-322410.3389/fimmu.2021.756042https://doaj.org/article/31713c80918a4bdc9d96b2bb322438e82021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.756042/fullhttps://doaj.org/toc/1664-3224T-lymphocytes (T cells) play a major role in adaptive immunity and current immune checkpoint inhibitor-based cancer treatments. The regulation of their function is complex, and in addition to cytokines, receptors and transcription factors, several non-coding RNAs (ncRNAs) have been shown to affect differentiation and function of T cells. Among these non-coding RNAs, certain small microRNAs (miRNAs) including miR-15a/16-1, miR-125b-5p, miR-99a-5p, miR-128-3p, let-7 family, miR-210, miR-182-5p, miR-181, miR-155 and miR-10a have been well recognized. Meanwhile, IFNG-AS1, lnc-ITSN1-2, lncRNA-CD160, NEAT1, MEG3, GAS5, NKILA, lnc-EGFR and PVT1 are among long non-coding RNAs (lncRNAs) that efficiently influence the function of T cells. Recent studies have underscored the effects of a number of circular RNAs, namely circ_0001806, hsa_circ_0045272, hsa_circ_0012919, hsa_circ_0005519 and circHIPK3 in the modulation of T-cell apoptosis, differentiation and secretion of cytokines. This review summarizes the latest news and regulatory roles of these ncRNAs on the function of T cells, with widespread implications on the pathophysiology of autoimmune disorders and cancer.Mohammad TaheriDominik A. BarthJulia KarglOmidvar RezaeiSoudeh Ghafouri-FardMartin PichlerMartin PichlerFrontiers Media S.A.articlemiRNAlncRNAcircRNAT cellcancerautoimmuneImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	miRNA lncRNA circRNA T cell cancer autoimmune Immunologic diseases. Allergy RC581-607
spellingShingle	miRNA lncRNA circRNA T cell cancer autoimmune Immunologic diseases. Allergy RC581-607 Mohammad Taheri Dominik A. Barth Julia Kargl Omidvar Rezaei Soudeh Ghafouri-Fard Martin Pichler Martin Pichler Emerging Role of Non-Coding RNAs in Regulation of T-Lymphocyte Function
description	T-lymphocytes (T cells) play a major role in adaptive immunity and current immune checkpoint inhibitor-based cancer treatments. The regulation of their function is complex, and in addition to cytokines, receptors and transcription factors, several non-coding RNAs (ncRNAs) have been shown to affect differentiation and function of T cells. Among these non-coding RNAs, certain small microRNAs (miRNAs) including miR-15a/16-1, miR-125b-5p, miR-99a-5p, miR-128-3p, let-7 family, miR-210, miR-182-5p, miR-181, miR-155 and miR-10a have been well recognized. Meanwhile, IFNG-AS1, lnc-ITSN1-2, lncRNA-CD160, NEAT1, MEG3, GAS5, NKILA, lnc-EGFR and PVT1 are among long non-coding RNAs (lncRNAs) that efficiently influence the function of T cells. Recent studies have underscored the effects of a number of circular RNAs, namely circ_0001806, hsa_circ_0045272, hsa_circ_0012919, hsa_circ_0005519 and circHIPK3 in the modulation of T-cell apoptosis, differentiation and secretion of cytokines. This review summarizes the latest news and regulatory roles of these ncRNAs on the function of T cells, with widespread implications on the pathophysiology of autoimmune disorders and cancer.
format	article
author	Mohammad Taheri Dominik A. Barth Julia Kargl Omidvar Rezaei Soudeh Ghafouri-Fard Martin Pichler Martin Pichler
author_facet	Mohammad Taheri Dominik A. Barth Julia Kargl Omidvar Rezaei Soudeh Ghafouri-Fard Martin Pichler Martin Pichler
author_sort	Mohammad Taheri
title	Emerging Role of Non-Coding RNAs in Regulation of T-Lymphocyte Function
title_short	Emerging Role of Non-Coding RNAs in Regulation of T-Lymphocyte Function
title_full	Emerging Role of Non-Coding RNAs in Regulation of T-Lymphocyte Function
title_fullStr	Emerging Role of Non-Coding RNAs in Regulation of T-Lymphocyte Function
title_full_unstemmed	Emerging Role of Non-Coding RNAs in Regulation of T-Lymphocyte Function
title_sort	emerging role of non-coding rnas in regulation of t-lymphocyte function
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/31713c80918a4bdc9d96b2bb322438e8
work_keys_str_mv	AT mohammadtaheri emergingroleofnoncodingrnasinregulationoftlymphocytefunction AT dominikabarth emergingroleofnoncodingrnasinregulationoftlymphocytefunction AT juliakargl emergingroleofnoncodingrnasinregulationoftlymphocytefunction AT omidvarrezaei emergingroleofnoncodingrnasinregulationoftlymphocytefunction AT soudehghafourifard emergingroleofnoncodingrnasinregulationoftlymphocytefunction AT martinpichler emergingroleofnoncodingrnasinregulationoftlymphocytefunction AT martinpichler emergingroleofnoncodingrnasinregulationoftlymphocytefunction
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Emerging Role of Non-Coding RNAs in Regulation of T-Lymphocyte Function

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