Transcranial alternating current stimulation enhances individual alpha activity in human EEG.

Non-invasive electrical stimulation of the human cortex by means of transcranial direct current stimulation (tDCS) has been instrumental in a number of important discoveries in the field of human cortical function and has become a well-established method for evaluating brain function in healthy huma...

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Autores principales:	Tino Zaehle, Stefan Rach, Christoph S Herrmann
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3171b8ae5c5e433c901e01d88a881003
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spelling	oai:doaj.org-article:3171b8ae5c5e433c901e01d88a8810032021-11-18T07:02:36ZTranscranial alternating current stimulation enhances individual alpha activity in human EEG.1932-620310.1371/journal.pone.0013766https://doaj.org/article/3171b8ae5c5e433c901e01d88a8810032010-11-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21072168/?tool=EBIhttps://doaj.org/toc/1932-6203Non-invasive electrical stimulation of the human cortex by means of transcranial direct current stimulation (tDCS) has been instrumental in a number of important discoveries in the field of human cortical function and has become a well-established method for evaluating brain function in healthy human participants. Recently, transcranial alternating current stimulation (tACS) has been introduced to directly modulate the ongoing rhythmic brain activity by the application of oscillatory currents on the human scalp. Until now the efficiency of tACS in modulating rhythmic brain activity has been indicated only by inference from perceptual and behavioural consequences of electrical stimulation. No direct electrophysiological evidence of tACS has been reported. We delivered tACS over the occipital cortex of 10 healthy participants to entrain the neuronal oscillatory activity in their individual alpha frequency range and compared results with those from a separate group of participants receiving sham stimulation. The tACS but not the sham stimulation elevated the endogenous alpha power in parieto-central electrodes of the electroencephalogram. Additionally, in a network of spiking neurons, we simulated how tACS can be affected even after the end of stimulation. The results show that spike-timing-dependent plasticity (STDP) selectively modulates synapses depending on the resonance frequencies of the neural circuits that they belong to. Thus, tACS influences STDP which in turn results in aftereffects upon neural activity.The present findings are the first direct electrophysiological evidence of an interaction of tACS and ongoing oscillatory activity in the human cortex. The data demonstrate the ability of tACS to specifically modulate oscillatory brain activity and show its potential both at fostering knowledge on the functional significance of brain oscillations and for therapeutic application.Tino ZaehleStefan RachChristoph S HerrmannPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 11, p e13766 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tino Zaehle Stefan Rach Christoph S Herrmann Transcranial alternating current stimulation enhances individual alpha activity in human EEG.
description	Non-invasive electrical stimulation of the human cortex by means of transcranial direct current stimulation (tDCS) has been instrumental in a number of important discoveries in the field of human cortical function and has become a well-established method for evaluating brain function in healthy human participants. Recently, transcranial alternating current stimulation (tACS) has been introduced to directly modulate the ongoing rhythmic brain activity by the application of oscillatory currents on the human scalp. Until now the efficiency of tACS in modulating rhythmic brain activity has been indicated only by inference from perceptual and behavioural consequences of electrical stimulation. No direct electrophysiological evidence of tACS has been reported. We delivered tACS over the occipital cortex of 10 healthy participants to entrain the neuronal oscillatory activity in their individual alpha frequency range and compared results with those from a separate group of participants receiving sham stimulation. The tACS but not the sham stimulation elevated the endogenous alpha power in parieto-central electrodes of the electroencephalogram. Additionally, in a network of spiking neurons, we simulated how tACS can be affected even after the end of stimulation. The results show that spike-timing-dependent plasticity (STDP) selectively modulates synapses depending on the resonance frequencies of the neural circuits that they belong to. Thus, tACS influences STDP which in turn results in aftereffects upon neural activity.The present findings are the first direct electrophysiological evidence of an interaction of tACS and ongoing oscillatory activity in the human cortex. The data demonstrate the ability of tACS to specifically modulate oscillatory brain activity and show its potential both at fostering knowledge on the functional significance of brain oscillations and for therapeutic application.
format	article
author	Tino Zaehle Stefan Rach Christoph S Herrmann
author_facet	Tino Zaehle Stefan Rach Christoph S Herrmann
author_sort	Tino Zaehle
title	Transcranial alternating current stimulation enhances individual alpha activity in human EEG.
title_short	Transcranial alternating current stimulation enhances individual alpha activity in human EEG.
title_full	Transcranial alternating current stimulation enhances individual alpha activity in human EEG.
title_fullStr	Transcranial alternating current stimulation enhances individual alpha activity in human EEG.
title_full_unstemmed	Transcranial alternating current stimulation enhances individual alpha activity in human EEG.
title_sort	transcranial alternating current stimulation enhances individual alpha activity in human eeg.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/3171b8ae5c5e433c901e01d88a881003
work_keys_str_mv	AT tinozaehle transcranialalternatingcurrentstimulationenhancesindividualalphaactivityinhumaneeg AT stefanrach transcranialalternatingcurrentstimulationenhancesindividualalphaactivityinhumaneeg AT christophsherrmann transcranialalternatingcurrentstimulationenhancesindividualalphaactivityinhumaneeg
_version_	1718424031654313984

Transcranial alternating current stimulation enhances individual alpha activity in human EEG.

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