Cortical spreading depression produces a neuroprotective effect activating mitochondrial uncoupling protein-5

Emanuela Viggiano,1,2 Vincenzo Monda,1 Antonietta Messina,1 Fiorenzo Moscatelli,3 Anna Valenzano,3 Domenico Tafuri,4 Giuseppe Cibelli,3 Bruno De Luca,1 Giovanni Messina,1,3 Marcellino Monda1 1Department of Experimental Medicine, Section of Human Physiology and Unit of Dietetics and Sports Medicine,...

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Autores principales:	Viggiano E, Monda V, Messina A, Moscatelli F, Valenzano A, Tafuri D, Cibelli G, De Luca B, Messina G, Monda M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Cortical Spreading Depression neuroprotective effect UCP5 Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/31777c00c6bb428e94b243cf3c3b54ba
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spelling	oai:doaj.org-article:31777c00c6bb428e94b243cf3c3b54ba2021-12-02T00:05:17ZCortical spreading depression produces a neuroprotective effect activating mitochondrial uncoupling protein-51178-2021https://doaj.org/article/31777c00c6bb428e94b243cf3c3b54ba2016-07-01T00:00:00Zhttps://www.dovepress.com/cortical-spreading-depression-produces-a-neuroprotective-effect-activa-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Emanuela Viggiano,1,2 Vincenzo Monda,1 Antonietta Messina,1 Fiorenzo Moscatelli,3 Anna Valenzano,3 Domenico Tafuri,4 Giuseppe Cibelli,3 Bruno De Luca,1 Giovanni Messina,1,3 Marcellino Monda1 1Department of Experimental Medicine, Section of Human Physiology and Unit of Dietetics and Sports Medicine, Second University of Naples, Naples, 2Department of Medicine, University of Padua, Padua, 3Department of Clinical and Experimental Medicine, University of Foggia, Foggia, 4Department of Motor Sciences and Wellness, University of Naples “Parthenope”, Naples, Italy Abstract: Depression of electrocorticogram propagating over the cortex surface results in cortical spreading depression (CSD), which is probably related to the pathophysiology of stroke, epilepsy, and migraine. However, preconditioning with CSD produces neuroprotection to subsequent ischemic episodes. Such effects require the expression or activation of several genes, including neuroprotective ones. Recently, it has been demonstrated that the expression of the uncoupling proteins (UCPs) 2 and 5 is amplified during brain ischemia and their expression exerts a long-term effect upon neuron protection. To evaluate the neuroprotective consequence of CSD, the expression of UCP-5 in the brain cortex was measured following CSD induction. CSD was evoked in four samples of rats, which were sacrificed after 2 hours, 4 hours, 6 hours, and 24 hours. Western blot analyses were carried out to measure UCP-5 concentrations in the prefrontal cortices of both hemispheres, and immunohistochemistry was performed to determine the localization of UCP-5 in the brain cortex. The results showed a significant elevation in UCP-5 expression at 24 hours in all cortical strata. Moreover, UCP-5 was triggered by CSD, indicating that UCP-5 production can have a neuroprotective effect. Keywords: cortical spreading depression, neuroprotective effect, uncoupling protein-5Viggiano EMonda VMessina AMoscatelli FValenzano ATafuri DCibelli GDe Luca BMessina GMonda MDove Medical PressarticleCortical Spreading Depressionneuroprotective effectUCP5Neurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2016, Iss Issue 1, Pp 1705-1710 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cortical Spreading Depression neuroprotective effect UCP5 Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Cortical Spreading Depression neuroprotective effect UCP5 Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Viggiano E Monda V Messina A Moscatelli F Valenzano A Tafuri D Cibelli G De Luca B Messina G Monda M Cortical spreading depression produces a neuroprotective effect activating mitochondrial uncoupling protein-5
description	Emanuela Viggiano,1,2 Vincenzo Monda,1 Antonietta Messina,1 Fiorenzo Moscatelli,3 Anna Valenzano,3 Domenico Tafuri,4 Giuseppe Cibelli,3 Bruno De Luca,1 Giovanni Messina,1,3 Marcellino Monda1 1Department of Experimental Medicine, Section of Human Physiology and Unit of Dietetics and Sports Medicine, Second University of Naples, Naples, 2Department of Medicine, University of Padua, Padua, 3Department of Clinical and Experimental Medicine, University of Foggia, Foggia, 4Department of Motor Sciences and Wellness, University of Naples “Parthenope”, Naples, Italy Abstract: Depression of electrocorticogram propagating over the cortex surface results in cortical spreading depression (CSD), which is probably related to the pathophysiology of stroke, epilepsy, and migraine. However, preconditioning with CSD produces neuroprotection to subsequent ischemic episodes. Such effects require the expression or activation of several genes, including neuroprotective ones. Recently, it has been demonstrated that the expression of the uncoupling proteins (UCPs) 2 and 5 is amplified during brain ischemia and their expression exerts a long-term effect upon neuron protection. To evaluate the neuroprotective consequence of CSD, the expression of UCP-5 in the brain cortex was measured following CSD induction. CSD was evoked in four samples of rats, which were sacrificed after 2 hours, 4 hours, 6 hours, and 24 hours. Western blot analyses were carried out to measure UCP-5 concentrations in the prefrontal cortices of both hemispheres, and immunohistochemistry was performed to determine the localization of UCP-5 in the brain cortex. The results showed a significant elevation in UCP-5 expression at 24 hours in all cortical strata. Moreover, UCP-5 was triggered by CSD, indicating that UCP-5 production can have a neuroprotective effect. Keywords: cortical spreading depression, neuroprotective effect, uncoupling protein-5
format	article
author	Viggiano E Monda V Messina A Moscatelli F Valenzano A Tafuri D Cibelli G De Luca B Messina G Monda M
author_facet	Viggiano E Monda V Messina A Moscatelli F Valenzano A Tafuri D Cibelli G De Luca B Messina G Monda M
author_sort	Viggiano E
title	Cortical spreading depression produces a neuroprotective effect activating mitochondrial uncoupling protein-5
title_short	Cortical spreading depression produces a neuroprotective effect activating mitochondrial uncoupling protein-5
title_full	Cortical spreading depression produces a neuroprotective effect activating mitochondrial uncoupling protein-5
title_fullStr	Cortical spreading depression produces a neuroprotective effect activating mitochondrial uncoupling protein-5
title_full_unstemmed	Cortical spreading depression produces a neuroprotective effect activating mitochondrial uncoupling protein-5
title_sort	cortical spreading depression produces a neuroprotective effect activating mitochondrial uncoupling protein-5
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/31777c00c6bb428e94b243cf3c3b54ba
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Cortical spreading depression produces a neuroprotective effect activating mitochondrial uncoupling protein-5

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