Incidence of malignancy and related mortality after kidney transplantation: a nationwide, population-based cohort study in Korea

Abstract Post-transplant malignancy (PTM) is a leading cause of premature mortality among kidney transplantation recipients. However, population-based cohort studies that cover incidence, mortality, and risk factors for PTM are rarely reported, especially in East Asia. We designed a retrospective co...

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Autores principales:	Seri Jeong, Ho Sup Lee, Seom Gim Kong, Da Jung Kim, Sangjin Lee, Min-Jeong Park, Wonkeun Song, John Hoon Rim, Hyung Jik Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/31796bceaed043459d80e8ca7d514641
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spelling	oai:doaj.org-article:31796bceaed043459d80e8ca7d5146412021-12-02T16:18:06ZIncidence of malignancy and related mortality after kidney transplantation: a nationwide, population-based cohort study in Korea10.1038/s41598-020-78283-52045-2322https://doaj.org/article/31796bceaed043459d80e8ca7d5146412020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-78283-5https://doaj.org/toc/2045-2322Abstract Post-transplant malignancy (PTM) is a leading cause of premature mortality among kidney transplantation recipients. However, population-based cohort studies that cover incidence, mortality, and risk factors for PTM are rarely reported, especially in East Asia. We designed a retrospective cohort study using a national population-based database. A total of 9915 kidney recipients between 2003 and 2016 were included. During this period, 598 cases (6.0%) of de novo PTM occurred. The most common PTM was thyroid cancer (14.2%), followed by colorectal (11.2%), kidney (10.7%), and stomach cancers (8.9%). The standardised incidence ratio for all-site cancer was 3.9. The risks of Kaposi sarcoma (192.9) and kidney cancer (21.1) were more than 10 times those of the general population. Cancer-related deaths were 89 (14.9%) with liver cancer being the highest (14.6%), followed by lung cancer (13.5%), non-Hodgkin lymphoma (NHL) (12.4%), stomach cancer (9.0%), and colorectal cancer (7.9%). The standardised mortality ratio (SMR) was slightly elevated (1.4). A notable increase in SMR was observed for lymphoma (9.3 for Hodgkin lymphoma and 5.5 for NHL). Older age and graft failure were significantly related to PTM. These findings reflecting geographical variation have implications for the development of strategies for fatal cancers to prevent premature deaths from PTM.Seri JeongHo Sup LeeSeom Gim KongDa Jung KimSangjin LeeMin-Jeong ParkWonkeun SongJohn Hoon RimHyung Jik KimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Seri Jeong Ho Sup Lee Seom Gim Kong Da Jung Kim Sangjin Lee Min-Jeong Park Wonkeun Song John Hoon Rim Hyung Jik Kim Incidence of malignancy and related mortality after kidney transplantation: a nationwide, population-based cohort study in Korea
description	Abstract Post-transplant malignancy (PTM) is a leading cause of premature mortality among kidney transplantation recipients. However, population-based cohort studies that cover incidence, mortality, and risk factors for PTM are rarely reported, especially in East Asia. We designed a retrospective cohort study using a national population-based database. A total of 9915 kidney recipients between 2003 and 2016 were included. During this period, 598 cases (6.0%) of de novo PTM occurred. The most common PTM was thyroid cancer (14.2%), followed by colorectal (11.2%), kidney (10.7%), and stomach cancers (8.9%). The standardised incidence ratio for all-site cancer was 3.9. The risks of Kaposi sarcoma (192.9) and kidney cancer (21.1) were more than 10 times those of the general population. Cancer-related deaths were 89 (14.9%) with liver cancer being the highest (14.6%), followed by lung cancer (13.5%), non-Hodgkin lymphoma (NHL) (12.4%), stomach cancer (9.0%), and colorectal cancer (7.9%). The standardised mortality ratio (SMR) was slightly elevated (1.4). A notable increase in SMR was observed for lymphoma (9.3 for Hodgkin lymphoma and 5.5 for NHL). Older age and graft failure were significantly related to PTM. These findings reflecting geographical variation have implications for the development of strategies for fatal cancers to prevent premature deaths from PTM.
format	article
author	Seri Jeong Ho Sup Lee Seom Gim Kong Da Jung Kim Sangjin Lee Min-Jeong Park Wonkeun Song John Hoon Rim Hyung Jik Kim
author_facet	Seri Jeong Ho Sup Lee Seom Gim Kong Da Jung Kim Sangjin Lee Min-Jeong Park Wonkeun Song John Hoon Rim Hyung Jik Kim
author_sort	Seri Jeong
title	Incidence of malignancy and related mortality after kidney transplantation: a nationwide, population-based cohort study in Korea
title_short	Incidence of malignancy and related mortality after kidney transplantation: a nationwide, population-based cohort study in Korea
title_full	Incidence of malignancy and related mortality after kidney transplantation: a nationwide, population-based cohort study in Korea
title_fullStr	Incidence of malignancy and related mortality after kidney transplantation: a nationwide, population-based cohort study in Korea
title_full_unstemmed	Incidence of malignancy and related mortality after kidney transplantation: a nationwide, population-based cohort study in Korea
title_sort	incidence of malignancy and related mortality after kidney transplantation: a nationwide, population-based cohort study in korea
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/31796bceaed043459d80e8ca7d514641
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Incidence of malignancy and related mortality after kidney transplantation: a nationwide, population-based cohort study in Korea

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