Rare and very rare adverse effects of clozapine

Pasquale De Fazio,1 Raffaele Gaetano,1 Mariarita Caroleo,1 Gregorio Cerminara,1 Francesca Maida,2 Antonio Bruno,3 Maria Rosaria Muscatello,3 Maria Jose Jaén Moreno,4 Emilio Russo,2 Cristina Segura-García1 1Department of Health Sciences, School of Specialization in Psychiatry,...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	De Fazio P, Gaetano R, Caroleo M, Cerminara G, Maida F, Bruno A, Muscatello MR, Jaén Moreno MJ, Russo E, Segura-García C
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/317ff5b6e07745f4aceae892a0b6d3b2
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:317ff5b6e07745f4aceae892a0b6d3b2
record_format	dspace
spelling	oai:doaj.org-article:317ff5b6e07745f4aceae892a0b6d3b22021-12-02T01:29:13ZRare and very rare adverse effects of clozapine1178-2021https://doaj.org/article/317ff5b6e07745f4aceae892a0b6d3b22015-08-01T00:00:00Zhttp://www.dovepress.com/rare-and-very-rare-adverse-effects-of-clozapine-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Pasquale De Fazio,1 Raffaele Gaetano,1 Mariarita Caroleo,1 Gregorio Cerminara,1 Francesca Maida,2 Antonio Bruno,3 Maria Rosaria Muscatello,3 Maria Jose Jaén Moreno,4 Emilio Russo,2 Cristina Segura-García1 1Department of Health Sciences, School of Specialization in Psychiatry, 2Department of Health Sciences, School of Specialization in Pharmacology, University “Magna Graecia”, Catanzaro, 3Department of Neurosciences, School of Specialization in Psychiatry, University of Messina, Messina, Italy; 4Department of Social Health Sciences, Radiology and Physical Medicine, University of Cordoba, Cordoba, Spain Abstract: Clozapine (CLZ) is the drug of choice for the treatment of resistant schizophrenia; however, its suitable use is limited by the complex adverse effects’ profile. The best-described adverse effects in the literature are represented by agranulocytosis, myocarditis, sedation, weight gain, hypotension, and drooling; nevertheless, there are other known adverse effects that psychiatrists should readily recognize and manage. This review covers the “rare” and “very rare” known adverse effects of CLZ, which have been accurately described in literature. An extensive search on the basis of predefined criteria was made using CLZ and its combination with adverse effects as keywords in electronic databases. Data show the association between the use of CLZ and uncommon adverse effects, including ischemic colitis, paralytic ileus, hematemesis, gastroesophageal reflux disease, priapism, urinary incontinence, pityriasis rosea, intertriginous erythema, pulmonary thromboembolism, pseudo-pheochromocytoma, periorbital edema, and parotitis, which are influenced by other variables including age, early diagnosis, and previous/current pharmacological therapies. Some of these adverse effects, although unpredictable, are often manageable if promptly recognized and treated. Others are serious and potentially life-threatening. However, an adequate knowledge of the drug, clinical vigilance, and rapid intervention can drastically reduce the morbidity and mortality related to CLZ treatment. Keywords: clozapine, rare adverse effects, schizophrenia, atypical antipsychoticDe Fazio PGaetano RCaroleo MCerminara GMaida FBruno AMuscatello MRJaén Moreno MJRusso ESegura-García CDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2015, Iss default, Pp 1995-2003 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 De Fazio P Gaetano R Caroleo M Cerminara G Maida F Bruno A Muscatello MR Jaén Moreno MJ Russo E Segura-García C Rare and very rare adverse effects of clozapine
description	Pasquale De Fazio,1 Raffaele Gaetano,1 Mariarita Caroleo,1 Gregorio Cerminara,1 Francesca Maida,2 Antonio Bruno,3 Maria Rosaria Muscatello,3 Maria Jose Jaén Moreno,4 Emilio Russo,2 Cristina Segura-García1 1Department of Health Sciences, School of Specialization in Psychiatry, 2Department of Health Sciences, School of Specialization in Pharmacology, University “Magna Graecia”, Catanzaro, 3Department of Neurosciences, School of Specialization in Psychiatry, University of Messina, Messina, Italy; 4Department of Social Health Sciences, Radiology and Physical Medicine, University of Cordoba, Cordoba, Spain Abstract: Clozapine (CLZ) is the drug of choice for the treatment of resistant schizophrenia; however, its suitable use is limited by the complex adverse effects’ profile. The best-described adverse effects in the literature are represented by agranulocytosis, myocarditis, sedation, weight gain, hypotension, and drooling; nevertheless, there are other known adverse effects that psychiatrists should readily recognize and manage. This review covers the “rare” and “very rare” known adverse effects of CLZ, which have been accurately described in literature. An extensive search on the basis of predefined criteria was made using CLZ and its combination with adverse effects as keywords in electronic databases. Data show the association between the use of CLZ and uncommon adverse effects, including ischemic colitis, paralytic ileus, hematemesis, gastroesophageal reflux disease, priapism, urinary incontinence, pityriasis rosea, intertriginous erythema, pulmonary thromboembolism, pseudo-pheochromocytoma, periorbital edema, and parotitis, which are influenced by other variables including age, early diagnosis, and previous/current pharmacological therapies. Some of these adverse effects, although unpredictable, are often manageable if promptly recognized and treated. Others are serious and potentially life-threatening. However, an adequate knowledge of the drug, clinical vigilance, and rapid intervention can drastically reduce the morbidity and mortality related to CLZ treatment. Keywords: clozapine, rare adverse effects, schizophrenia, atypical antipsychotic
format	article
author	De Fazio P Gaetano R Caroleo M Cerminara G Maida F Bruno A Muscatello MR Jaén Moreno MJ Russo E Segura-García C
author_facet	De Fazio P Gaetano R Caroleo M Cerminara G Maida F Bruno A Muscatello MR Jaén Moreno MJ Russo E Segura-García C
author_sort	De Fazio P
title	Rare and very rare adverse effects of clozapine
title_short	Rare and very rare adverse effects of clozapine
title_full	Rare and very rare adverse effects of clozapine
title_fullStr	Rare and very rare adverse effects of clozapine
title_full_unstemmed	Rare and very rare adverse effects of clozapine
title_sort	rare and very rare adverse effects of clozapine
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/317ff5b6e07745f4aceae892a0b6d3b2
work_keys_str_mv	AT defaziop rareandveryrareadverseeffectsofclozapine AT gaetanor rareandveryrareadverseeffectsofclozapine AT caroleom rareandveryrareadverseeffectsofclozapine AT cerminarag rareandveryrareadverseeffectsofclozapine AT maidaf rareandveryrareadverseeffectsofclozapine AT brunoa rareandveryrareadverseeffectsofclozapine AT muscatellomr rareandveryrareadverseeffectsofclozapine AT jaenmorenomj rareandveryrareadverseeffectsofclozapine AT russoe rareandveryrareadverseeffectsofclozapine AT seguragarciac rareandveryrareadverseeffectsofclozapine
_version_	1718403007170740224

Rare and very rare adverse effects of clozapine

Ejemplares similares