The plasma membrane calcium ATPase 4 signalling in cardiac fibroblasts mediates cardiomyocyte hypertrophy

Restricting hypertrophic heart growth in response to pathologic overload is an unmet therapeutic need. Here, the authors show that blocking Ca2+signaling controlled by the transport protein PMCA4 in cardiac fibroblasts enhances secretion of a potent Wnt signaling inhibitor, sFRP2, and prevents the d...

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Autores principales:	Tamer M. A. Mohamed, Riham Abou-Leisa, Nicholas Stafford, Arfa Maqsood, Min Zi, Sukhpal Prehar, Florence Baudoin-Stanley, Xin Wang, Ludwig Neyses, Elizabeth J. Cartwright, Delvac Oceandy
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3181bc8460874c778601d9d69e9cba89
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spelling	oai:doaj.org-article:3181bc8460874c778601d9d69e9cba892021-12-02T17:31:32ZThe plasma membrane calcium ATPase 4 signalling in cardiac fibroblasts mediates cardiomyocyte hypertrophy10.1038/ncomms110742041-1723https://doaj.org/article/3181bc8460874c778601d9d69e9cba892016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms11074https://doaj.org/toc/2041-1723Restricting hypertrophic heart growth in response to pathologic overload is an unmet therapeutic need. Here, the authors show that blocking Ca2+signaling controlled by the transport protein PMCA4 in cardiac fibroblasts enhances secretion of a potent Wnt signaling inhibitor, sFRP2, and prevents the development of pathologic cardiac hypertrophy in mice.Tamer M. A. MohamedRiham Abou-LeisaNicholas StaffordArfa MaqsoodMin ZiSukhpal PreharFlorence Baudoin-StanleyXin WangLudwig NeysesElizabeth J. CartwrightDelvac OceandyNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tamer M. A. Mohamed Riham Abou-Leisa Nicholas Stafford Arfa Maqsood Min Zi Sukhpal Prehar Florence Baudoin-Stanley Xin Wang Ludwig Neyses Elizabeth J. Cartwright Delvac Oceandy The plasma membrane calcium ATPase 4 signalling in cardiac fibroblasts mediates cardiomyocyte hypertrophy
description	Restricting hypertrophic heart growth in response to pathologic overload is an unmet therapeutic need. Here, the authors show that blocking Ca2+signaling controlled by the transport protein PMCA4 in cardiac fibroblasts enhances secretion of a potent Wnt signaling inhibitor, sFRP2, and prevents the development of pathologic cardiac hypertrophy in mice.
format	article
author	Tamer M. A. Mohamed Riham Abou-Leisa Nicholas Stafford Arfa Maqsood Min Zi Sukhpal Prehar Florence Baudoin-Stanley Xin Wang Ludwig Neyses Elizabeth J. Cartwright Delvac Oceandy
author_facet	Tamer M. A. Mohamed Riham Abou-Leisa Nicholas Stafford Arfa Maqsood Min Zi Sukhpal Prehar Florence Baudoin-Stanley Xin Wang Ludwig Neyses Elizabeth J. Cartwright Delvac Oceandy
author_sort	Tamer M. A. Mohamed
title	The plasma membrane calcium ATPase 4 signalling in cardiac fibroblasts mediates cardiomyocyte hypertrophy
title_short	The plasma membrane calcium ATPase 4 signalling in cardiac fibroblasts mediates cardiomyocyte hypertrophy
title_full	The plasma membrane calcium ATPase 4 signalling in cardiac fibroblasts mediates cardiomyocyte hypertrophy
title_fullStr	The plasma membrane calcium ATPase 4 signalling in cardiac fibroblasts mediates cardiomyocyte hypertrophy
title_full_unstemmed	The plasma membrane calcium ATPase 4 signalling in cardiac fibroblasts mediates cardiomyocyte hypertrophy
title_sort	plasma membrane calcium atpase 4 signalling in cardiac fibroblasts mediates cardiomyocyte hypertrophy
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/3181bc8460874c778601d9d69e9cba89
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The plasma membrane calcium ATPase 4 signalling in cardiac fibroblasts mediates cardiomyocyte hypertrophy

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