Regulation of PERK–eIF2α signalling by tuberous sclerosis complex-1 controls homoeostasis and survival of myelinating oligodendrocytes

The molecular mechanisms regulating myelination are only partially understood. Here authors show that Tsc1ablation in oligodendrocyte lineage activates ER stress and apoptotic programs in mice, and that enhancing PERK-eIF2α signalling partially rescues the myelination defects in Tsc1 mutants.

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Autores principales:	Minqing Jiang, Lei Liu, Xuelian He, Haibo Wang, Wensheng Lin, Huimin Wang, Sung O. Yoon, Teresa L. Wood, Q. Richard Lu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3183cd29a5be4f2ab4d6cef95ce98db7
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spelling	oai:doaj.org-article:3183cd29a5be4f2ab4d6cef95ce98db72021-12-02T14:38:33ZRegulation of PERK–eIF2α signalling by tuberous sclerosis complex-1 controls homoeostasis and survival of myelinating oligodendrocytes10.1038/ncomms121852041-1723https://doaj.org/article/3183cd29a5be4f2ab4d6cef95ce98db72016-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms12185https://doaj.org/toc/2041-1723The molecular mechanisms regulating myelination are only partially understood. Here authors show that Tsc1ablation in oligodendrocyte lineage activates ER stress and apoptotic programs in mice, and that enhancing PERK-eIF2α signalling partially rescues the myelination defects in Tsc1 mutants.Minqing JiangLei LiuXuelian HeHaibo WangWensheng LinHuimin WangSung O. YoonTeresa L. WoodQ. Richard LuNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Minqing Jiang Lei Liu Xuelian He Haibo Wang Wensheng Lin Huimin Wang Sung O. Yoon Teresa L. Wood Q. Richard Lu Regulation of PERK–eIF2α signalling by tuberous sclerosis complex-1 controls homoeostasis and survival of myelinating oligodendrocytes
description	The molecular mechanisms regulating myelination are only partially understood. Here authors show that Tsc1ablation in oligodendrocyte lineage activates ER stress and apoptotic programs in mice, and that enhancing PERK-eIF2α signalling partially rescues the myelination defects in Tsc1 mutants.
format	article
author	Minqing Jiang Lei Liu Xuelian He Haibo Wang Wensheng Lin Huimin Wang Sung O. Yoon Teresa L. Wood Q. Richard Lu
author_facet	Minqing Jiang Lei Liu Xuelian He Haibo Wang Wensheng Lin Huimin Wang Sung O. Yoon Teresa L. Wood Q. Richard Lu
author_sort	Minqing Jiang
title	Regulation of PERK–eIF2α signalling by tuberous sclerosis complex-1 controls homoeostasis and survival of myelinating oligodendrocytes
title_short	Regulation of PERK–eIF2α signalling by tuberous sclerosis complex-1 controls homoeostasis and survival of myelinating oligodendrocytes
title_full	Regulation of PERK–eIF2α signalling by tuberous sclerosis complex-1 controls homoeostasis and survival of myelinating oligodendrocytes
title_fullStr	Regulation of PERK–eIF2α signalling by tuberous sclerosis complex-1 controls homoeostasis and survival of myelinating oligodendrocytes
title_full_unstemmed	Regulation of PERK–eIF2α signalling by tuberous sclerosis complex-1 controls homoeostasis and survival of myelinating oligodendrocytes
title_sort	regulation of perk–eif2α signalling by tuberous sclerosis complex-1 controls homoeostasis and survival of myelinating oligodendrocytes
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/3183cd29a5be4f2ab4d6cef95ce98db7
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Regulation of PERK–eIF2α signalling by tuberous sclerosis complex-1 controls homoeostasis and survival of myelinating oligodendrocytes

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