DNA methylation as a mediator of HLA-DRB1*15:01 and a protective variant in multiple sclerosis
The human leukocyte antigen (HLA) haplotype DRB1*15:01 is the major risk factor for multiple sclerosis (MS). Here the authors find that DNA methylation at HLA-DRB1 gene mediates the effect of DRB1*15:01 and of a protective HLA variant on HLA-DRB1 expression and the risk of MS.
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Nature Portfolio
2018
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oai:doaj.org-article:31861db392bf46669b4a789c9a333f742021-12-02T17:33:17ZDNA methylation as a mediator of HLA-DRB1*15:01 and a protective variant in multiple sclerosis10.1038/s41467-018-04732-52041-1723https://doaj.org/article/31861db392bf46669b4a789c9a333f742018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04732-5https://doaj.org/toc/2041-1723The human leukocyte antigen (HLA) haplotype DRB1*15:01 is the major risk factor for multiple sclerosis (MS). Here the authors find that DNA methylation at HLA-DRB1 gene mediates the effect of DRB1*15:01 and of a protective HLA variant on HLA-DRB1 expression and the risk of MS.Lara KularYun LiuSabrina RuhrmannGalina ZheleznyakovaFrancesco MarabitaDavid Gomez-CabreroTojo JamesEwoud EwingMagdalena LindénBartosz GórnikiewiczShahin AeinehbandPernilla StridhJenny LinkTill F. M. AndlauerChristiane GasperiHeinz WiendlFrauke ZippRalf GoldBjörn TackenbergFrank WeberBernhard HemmerKonstantin StrauchStefanie Heilmann-HeimbachRajesh RawalUlf SchminkeCarsten O. SchmidtTim KacprowskiAndre FrankeMatthias LaudesAlexander T. DiltheyElisabeth G. CeliusHelle B. SøndergaardJesper TegnérHanne F. HarboAnnette B. OturaiSigurgeir OlafssonHannes P. EggertssonBjarni V. HalldorssonHaukur HjaltasonElias OlafssonIngileif JonsdottirKari StefanssonTomas OlssonFredrik PiehlTomas J. EkströmIngrid KockumAndrew P. FeinbergMaja JagodicNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018) |
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DOAJ |
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DOAJ |
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EN |
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Science Q |
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Science Q Lara Kular Yun Liu Sabrina Ruhrmann Galina Zheleznyakova Francesco Marabita David Gomez-Cabrero Tojo James Ewoud Ewing Magdalena Lindén Bartosz Górnikiewicz Shahin Aeinehband Pernilla Stridh Jenny Link Till F. M. Andlauer Christiane Gasperi Heinz Wiendl Frauke Zipp Ralf Gold Björn Tackenberg Frank Weber Bernhard Hemmer Konstantin Strauch Stefanie Heilmann-Heimbach Rajesh Rawal Ulf Schminke Carsten O. Schmidt Tim Kacprowski Andre Franke Matthias Laudes Alexander T. Dilthey Elisabeth G. Celius Helle B. Søndergaard Jesper Tegnér Hanne F. Harbo Annette B. Oturai Sigurgeir Olafsson Hannes P. Eggertsson Bjarni V. Halldorsson Haukur Hjaltason Elias Olafsson Ingileif Jonsdottir Kari Stefansson Tomas Olsson Fredrik Piehl Tomas J. Ekström Ingrid Kockum Andrew P. Feinberg Maja Jagodic DNA methylation as a mediator of HLA-DRB1*15:01 and a protective variant in multiple sclerosis |
| description |
The human leukocyte antigen (HLA) haplotype DRB1*15:01 is the major risk factor for multiple sclerosis (MS). Here the authors find that DNA methylation at HLA-DRB1 gene mediates the effect of DRB1*15:01 and of a protective HLA variant on HLA-DRB1 expression and the risk of MS. |
| format |
article |
| author |
Lara Kular Yun Liu Sabrina Ruhrmann Galina Zheleznyakova Francesco Marabita David Gomez-Cabrero Tojo James Ewoud Ewing Magdalena Lindén Bartosz Górnikiewicz Shahin Aeinehband Pernilla Stridh Jenny Link Till F. M. Andlauer Christiane Gasperi Heinz Wiendl Frauke Zipp Ralf Gold Björn Tackenberg Frank Weber Bernhard Hemmer Konstantin Strauch Stefanie Heilmann-Heimbach Rajesh Rawal Ulf Schminke Carsten O. Schmidt Tim Kacprowski Andre Franke Matthias Laudes Alexander T. Dilthey Elisabeth G. Celius Helle B. Søndergaard Jesper Tegnér Hanne F. Harbo Annette B. Oturai Sigurgeir Olafsson Hannes P. Eggertsson Bjarni V. Halldorsson Haukur Hjaltason Elias Olafsson Ingileif Jonsdottir Kari Stefansson Tomas Olsson Fredrik Piehl Tomas J. Ekström Ingrid Kockum Andrew P. Feinberg Maja Jagodic |
| author_facet |
Lara Kular Yun Liu Sabrina Ruhrmann Galina Zheleznyakova Francesco Marabita David Gomez-Cabrero Tojo James Ewoud Ewing Magdalena Lindén Bartosz Górnikiewicz Shahin Aeinehband Pernilla Stridh Jenny Link Till F. M. Andlauer Christiane Gasperi Heinz Wiendl Frauke Zipp Ralf Gold Björn Tackenberg Frank Weber Bernhard Hemmer Konstantin Strauch Stefanie Heilmann-Heimbach Rajesh Rawal Ulf Schminke Carsten O. Schmidt Tim Kacprowski Andre Franke Matthias Laudes Alexander T. Dilthey Elisabeth G. Celius Helle B. Søndergaard Jesper Tegnér Hanne F. Harbo Annette B. Oturai Sigurgeir Olafsson Hannes P. Eggertsson Bjarni V. Halldorsson Haukur Hjaltason Elias Olafsson Ingileif Jonsdottir Kari Stefansson Tomas Olsson Fredrik Piehl Tomas J. Ekström Ingrid Kockum Andrew P. Feinberg Maja Jagodic |
| author_sort |
Lara Kular |
| title |
DNA methylation as a mediator of HLA-DRB1*15:01 and a protective variant in multiple sclerosis |
| title_short |
DNA methylation as a mediator of HLA-DRB1*15:01 and a protective variant in multiple sclerosis |
| title_full |
DNA methylation as a mediator of HLA-DRB1*15:01 and a protective variant in multiple sclerosis |
| title_fullStr |
DNA methylation as a mediator of HLA-DRB1*15:01 and a protective variant in multiple sclerosis |
| title_full_unstemmed |
DNA methylation as a mediator of HLA-DRB1*15:01 and a protective variant in multiple sclerosis |
| title_sort |
dna methylation as a mediator of hla-drb1*15:01 and a protective variant in multiple sclerosis |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/31861db392bf46669b4a789c9a333f74 |
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