Innovative Synoptic Reporting With Seven-Point Sampling Protocol to Improve Detection Rate of Microvascular Invasion in Hepatocellular Carcinoma
Pathological MVI diagnosis could help to determine the prognosis and need for adjuvant therapy in hepatocellular carcinoma (HCC). However, narrative reporting (NR) would miss relevant clinical information and non-standardized sampling would underestimate MVI detection. Our objective was to explore t...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:3186ebff8d7f4107b43e4cffac66aecb2021-11-04T05:03:11ZInnovative Synoptic Reporting With Seven-Point Sampling Protocol to Improve Detection Rate of Microvascular Invasion in Hepatocellular Carcinoma2234-943X10.3389/fonc.2021.726239https://doaj.org/article/3186ebff8d7f4107b43e4cffac66aecb2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.726239/fullhttps://doaj.org/toc/2234-943XPathological MVI diagnosis could help to determine the prognosis and need for adjuvant therapy in hepatocellular carcinoma (HCC). However, narrative reporting (NR) would miss relevant clinical information and non-standardized sampling would underestimate MVI detection. Our objective was to explore the impact of innovative synoptic reporting (SR) and seven-point sampling (SPRING) protocol on microvascular invasion (MVI) rate and patient outcomes. In retrospective cohort, we extracted MVI status from NR in three centers and re-reviewed specimen sections by SR recommended by the College of American Pathologists (CAP) in our center. In prospective cohort, our center implemented the SPRING protocol, and external centers remained traditional pathological examination. MVI rate was compared between our center and external centers in both cohorts. Recurrence-free survival (RFS) before and after implementation was calculated by Kaplan-Meier method and compared by the log-rank test. In retrospective study, we found there was no significant difference in MVI rate between our center and external centers [10.3% (115/1112) vs. 12.4% (35/282), P=0.316]. In our center, SR recommended by CAP improved the MVI detection rate from 10.3 to 38.6% (P<0.001). In prospective study, the MVI rate in our center under SPRING was significantly higher than external centers (53.2 vs. 17%, P<0.001). RFS of MVI (−) patients improved after SPRING in our center (P=0.010), but it remained unchanged in MVI (+) patients (P=0.200). We conclude that the SR recommended by CAP could help to improve MVI detection rate. Our SPRING protocol could help to further improve the MVI rate and optimize prognostic stratification for HCC patients.Bing LiaoLijuan LiuLihong WeiYuefeng WangLili ChenQinghua CaoQian ZhouHan XiaoShuling ChenSui PengSui PengSui PengShaoqiang LiMing KuangMing KuangMing KuangFrontiers Media S.A.articlehepatocellular carcinomamicrovascular invasioninnovative synoptic reportingseven-point samplingSPRING protocolNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021) |
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| collection |
DOAJ |
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EN |
| topic |
hepatocellular carcinoma microvascular invasion innovative synoptic reporting seven-point sampling SPRING protocol Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 |
| spellingShingle |
hepatocellular carcinoma microvascular invasion innovative synoptic reporting seven-point sampling SPRING protocol Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Bing Liao Lijuan Liu Lihong Wei Yuefeng Wang Lili Chen Qinghua Cao Qian Zhou Han Xiao Shuling Chen Sui Peng Sui Peng Sui Peng Shaoqiang Li Ming Kuang Ming Kuang Ming Kuang Innovative Synoptic Reporting With Seven-Point Sampling Protocol to Improve Detection Rate of Microvascular Invasion in Hepatocellular Carcinoma |
| description |
Pathological MVI diagnosis could help to determine the prognosis and need for adjuvant therapy in hepatocellular carcinoma (HCC). However, narrative reporting (NR) would miss relevant clinical information and non-standardized sampling would underestimate MVI detection. Our objective was to explore the impact of innovative synoptic reporting (SR) and seven-point sampling (SPRING) protocol on microvascular invasion (MVI) rate and patient outcomes. In retrospective cohort, we extracted MVI status from NR in three centers and re-reviewed specimen sections by SR recommended by the College of American Pathologists (CAP) in our center. In prospective cohort, our center implemented the SPRING protocol, and external centers remained traditional pathological examination. MVI rate was compared between our center and external centers in both cohorts. Recurrence-free survival (RFS) before and after implementation was calculated by Kaplan-Meier method and compared by the log-rank test. In retrospective study, we found there was no significant difference in MVI rate between our center and external centers [10.3% (115/1112) vs. 12.4% (35/282), P=0.316]. In our center, SR recommended by CAP improved the MVI detection rate from 10.3 to 38.6% (P<0.001). In prospective study, the MVI rate in our center under SPRING was significantly higher than external centers (53.2 vs. 17%, P<0.001). RFS of MVI (−) patients improved after SPRING in our center (P=0.010), but it remained unchanged in MVI (+) patients (P=0.200). We conclude that the SR recommended by CAP could help to improve MVI detection rate. Our SPRING protocol could help to further improve the MVI rate and optimize prognostic stratification for HCC patients. |
| format |
article |
| author |
Bing Liao Lijuan Liu Lihong Wei Yuefeng Wang Lili Chen Qinghua Cao Qian Zhou Han Xiao Shuling Chen Sui Peng Sui Peng Sui Peng Shaoqiang Li Ming Kuang Ming Kuang Ming Kuang |
| author_facet |
Bing Liao Lijuan Liu Lihong Wei Yuefeng Wang Lili Chen Qinghua Cao Qian Zhou Han Xiao Shuling Chen Sui Peng Sui Peng Sui Peng Shaoqiang Li Ming Kuang Ming Kuang Ming Kuang |
| author_sort |
Bing Liao |
| title |
Innovative Synoptic Reporting With Seven-Point Sampling Protocol to Improve Detection Rate of Microvascular Invasion in Hepatocellular Carcinoma |
| title_short |
Innovative Synoptic Reporting With Seven-Point Sampling Protocol to Improve Detection Rate of Microvascular Invasion in Hepatocellular Carcinoma |
| title_full |
Innovative Synoptic Reporting With Seven-Point Sampling Protocol to Improve Detection Rate of Microvascular Invasion in Hepatocellular Carcinoma |
| title_fullStr |
Innovative Synoptic Reporting With Seven-Point Sampling Protocol to Improve Detection Rate of Microvascular Invasion in Hepatocellular Carcinoma |
| title_full_unstemmed |
Innovative Synoptic Reporting With Seven-Point Sampling Protocol to Improve Detection Rate of Microvascular Invasion in Hepatocellular Carcinoma |
| title_sort |
innovative synoptic reporting with seven-point sampling protocol to improve detection rate of microvascular invasion in hepatocellular carcinoma |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/3186ebff8d7f4107b43e4cffac66aecb |
| work_keys_str_mv |
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