Visible-light-responsive ZnCuO nanoparticles: benign photodynamic killers of infectious protozoans

Akhtar Nadhman,1,2 Samina Nazir,2 Malik Ihsanullah Khan,1 Attiya Ayub,2,3 Bakhtiar Muhammad,3 Momin Khan,1 Dilawar Farhan Shams,4 Masoom Yasinzai1,5 1Department of Biotechnology, Quaid-i-Azam University, Islamabad, Pakistan; 2Nanosciences and Catalysis Division, National Centre for Physics, Quaid-i-...

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Autores principales:	Nadhman A, Nazir S, Khan MI, Ayub A, Muhammad B, Khan M, Shams DF, Yasinzai M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/318996f0842e419880733ef3a814bb51
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spelling	oai:doaj.org-article:318996f0842e419880733ef3a814bb512021-12-02T11:01:33ZVisible-light-responsive ZnCuO nanoparticles: benign photodynamic killers of infectious protozoans1178-2013https://doaj.org/article/318996f0842e419880733ef3a814bb512015-11-01T00:00:00Zhttps://www.dovepress.com/visible-light-responsive-zncuo-nanoparticles-benign-photodynamic-kille-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Akhtar Nadhman,1,2 Samina Nazir,2 Malik Ihsanullah Khan,1 Attiya Ayub,2,3 Bakhtiar Muhammad,3 Momin Khan,1 Dilawar Farhan Shams,4 Masoom Yasinzai1,5 1Department of Biotechnology, Quaid-i-Azam University, Islamabad, Pakistan; 2Nanosciences and Catalysis Division, National Centre for Physics, Quaid-i-Azam University Campus, Islamabad, Pakistan; 3Department of Chemistry, Hazara University, Dhodial, Pakistan; 4Department of Environmental Sciences, Abdul Wali Khan University Mardan, Mardan, Pakistan; 5Center of Interdisciplinary Research, International Islamic University, Islamabad, Pakistan Abstract: Human beings suffer from several infectious agents such as viruses, bacteria, and protozoans. Recently, there has been a great interest in developing biocompatible nanostructures to deal with infectious agents. This study investigated benign ZnCuO nanostructures that were visible-light-responsive due to the resident copper in the lattice. The nanostructures were synthesized through a size-controlled hot-injection process, which was adaptable to the surface ligation processes. The nanostructures were then characterized through transmission electron microscopy, X-ray diffraction, diffused reflectance spectroscopy, Rutherford backscattering, and photoluminescence analysis to measure crystallite nature, size, luminescence, composition, and band-gap analyses. Antiprotozoal efficiency of the current nanoparticles revealed the photodynamic killing of Leishmania protozoan, thus acting as efficient metal-based photosensitizers. The crystalline nanoparticles showed good biocompatibility when tested for macrophage toxicity and in hemolysis assays. The study opens a wide avenue for using toxic material in resident nontoxic forms as an effective antiprotozoal treatment. Keywords: zinc oxide, nanoparticles, doping, photodynamic therapy, LeishmaniaNadhman ANazir SKhan MIAyub AMuhammad BKhan MShams DFYasinzai MDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2015, Iss default, Pp 6891-6903 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Nadhman A Nazir S Khan MI Ayub A Muhammad B Khan M Shams DF Yasinzai M Visible-light-responsive ZnCuO nanoparticles: benign photodynamic killers of infectious protozoans
description	Akhtar Nadhman,1,2 Samina Nazir,2 Malik Ihsanullah Khan,1 Attiya Ayub,2,3 Bakhtiar Muhammad,3 Momin Khan,1 Dilawar Farhan Shams,4 Masoom Yasinzai1,5 1Department of Biotechnology, Quaid-i-Azam University, Islamabad, Pakistan; 2Nanosciences and Catalysis Division, National Centre for Physics, Quaid-i-Azam University Campus, Islamabad, Pakistan; 3Department of Chemistry, Hazara University, Dhodial, Pakistan; 4Department of Environmental Sciences, Abdul Wali Khan University Mardan, Mardan, Pakistan; 5Center of Interdisciplinary Research, International Islamic University, Islamabad, Pakistan Abstract: Human beings suffer from several infectious agents such as viruses, bacteria, and protozoans. Recently, there has been a great interest in developing biocompatible nanostructures to deal with infectious agents. This study investigated benign ZnCuO nanostructures that were visible-light-responsive due to the resident copper in the lattice. The nanostructures were synthesized through a size-controlled hot-injection process, which was adaptable to the surface ligation processes. The nanostructures were then characterized through transmission electron microscopy, X-ray diffraction, diffused reflectance spectroscopy, Rutherford backscattering, and photoluminescence analysis to measure crystallite nature, size, luminescence, composition, and band-gap analyses. Antiprotozoal efficiency of the current nanoparticles revealed the photodynamic killing of Leishmania protozoan, thus acting as efficient metal-based photosensitizers. The crystalline nanoparticles showed good biocompatibility when tested for macrophage toxicity and in hemolysis assays. The study opens a wide avenue for using toxic material in resident nontoxic forms as an effective antiprotozoal treatment. Keywords: zinc oxide, nanoparticles, doping, photodynamic therapy, Leishmania
format	article
author	Nadhman A Nazir S Khan MI Ayub A Muhammad B Khan M Shams DF Yasinzai M
author_facet	Nadhman A Nazir S Khan MI Ayub A Muhammad B Khan M Shams DF Yasinzai M
author_sort	Nadhman A
title	Visible-light-responsive ZnCuO nanoparticles: benign photodynamic killers of infectious protozoans
title_short	Visible-light-responsive ZnCuO nanoparticles: benign photodynamic killers of infectious protozoans
title_full	Visible-light-responsive ZnCuO nanoparticles: benign photodynamic killers of infectious protozoans
title_fullStr	Visible-light-responsive ZnCuO nanoparticles: benign photodynamic killers of infectious protozoans
title_full_unstemmed	Visible-light-responsive ZnCuO nanoparticles: benign photodynamic killers of infectious protozoans
title_sort	visible-light-responsive zncuo nanoparticles: benign photodynamic killers of infectious protozoans
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/318996f0842e419880733ef3a814bb51
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Visible-light-responsive ZnCuO nanoparticles: benign photodynamic killers of infectious protozoans

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