Electronic Data Management for Vaccine Trials in Low Resource Settings: Upgrades, Scalability, and Impact of ODK

Background: ODK provides software and standards that are popular solutions for off-grid electronic data collection and has substantial code overlap and interoperability with a number of related software products including CommCare, Enketo, Ona, SurveyCTO, and KoBoToolbox. These tools provide open-so...

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Autores principales:	Michael Marks, Sham Lal, Hannah Brindle, Pierre-Stéphane Gsell, Matthew MacGregor, Callum Stott, Martijn van de Rijdt, Guillermo Gutiérrez Almazor, Suman Golia, Conall Watson, Abdourahamane Diallo, Alhassane Toure, Catherine Houlihan, Patrick Keating, Hélène Martin, Ana-Maria Henao Restrepo, Yaw Anokwa, Chrissy H. Roberts
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	Ebola open-data-kit open source software electronic data collection low and middle income countries Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/318cbca4382141ec8ca751f7eedf54df
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spelling	oai:doaj.org-article:318cbca4382141ec8ca751f7eedf54df2021-11-04T05:09:51ZElectronic Data Management for Vaccine Trials in Low Resource Settings: Upgrades, Scalability, and Impact of ODK2296-256510.3389/fpubh.2021.665584https://doaj.org/article/318cbca4382141ec8ca751f7eedf54df2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fpubh.2021.665584/fullhttps://doaj.org/toc/2296-2565Background: ODK provides software and standards that are popular solutions for off-grid electronic data collection and has substantial code overlap and interoperability with a number of related software products including CommCare, Enketo, Ona, SurveyCTO, and KoBoToolbox. These tools provide open-source options for off-grid use in public health data collection, management, analysis, and reporting. During the 2018–2020 Ebola epidemic in the North Kivu and Ituri regions of Democratic Republic of Congo, we used these tools to support the DRC Ministère de la Santé RDC and World Health Organization in their efforts to administer an experimental vaccine (VSV-Zebov-GP) as part of their strategy to control the transmission of infection.Method: New functions were developed to facilitate the use of ODK, Enketo and R in large scale data collection, aggregation, monitoring, and near-real-time analysis during clinical research in health emergencies. We present enhancements to ODK that include a built-in audit-trail, a framework and companion app for biometric registration of ISO/IEC 19794-2 fingerprint templates, enhanced performance features, better scalability for studies featuring millions of data form submissions, increased options for parallelization of research projects, and pipelines for automated management and analysis of data. We also developed novel encryption protocols for enhanced web-form security in Enketo.Results: Against the backdrop of a complex and challenging epidemic response, our enhanced platform of open tools was used to collect and manage data from more than 280,000 eligible study participants who received VSV-Zebov-GP under informed consent. These data were used to determine whether the VSV-Zebov-GP was safe and effective and to guide daily field operations.Conclusions: We present open-source developments that make electronic data management during clinical research and health emergencies more viable and robust. These developments will also enhance and expand the functionality of a diverse range of data collection platforms that are based on the ODK software and standards.Michael MarksSham LalHannah BrindlePierre-Stéphane GsellMatthew MacGregorCallum StottMartijn van de RijdtGuillermo Gutiérrez AlmazorSuman GoliaConall WatsonAbdourahamane DialloAlhassane ToureCatherine HoulihanPatrick KeatingPatrick KeatingHélène MartinAna-Maria Henao RestrepoYaw AnokwaChrissy H. RobertsFrontiers Media S.A.articleEbolaopen-data-kitopen source softwareelectronic data collectionlow and middle income countriesPublic aspects of medicineRA1-1270ENFrontiers in Public Health, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ebola open-data-kit open source software electronic data collection low and middle income countries Public aspects of medicine RA1-1270
spellingShingle	Ebola open-data-kit open source software electronic data collection low and middle income countries Public aspects of medicine RA1-1270 Michael Marks Sham Lal Hannah Brindle Pierre-Stéphane Gsell Matthew MacGregor Callum Stott Martijn van de Rijdt Guillermo Gutiérrez Almazor Suman Golia Conall Watson Abdourahamane Diallo Alhassane Toure Catherine Houlihan Patrick Keating Patrick Keating Hélène Martin Ana-Maria Henao Restrepo Yaw Anokwa Chrissy H. Roberts Electronic Data Management for Vaccine Trials in Low Resource Settings: Upgrades, Scalability, and Impact of ODK
description	Background: ODK provides software and standards that are popular solutions for off-grid electronic data collection and has substantial code overlap and interoperability with a number of related software products including CommCare, Enketo, Ona, SurveyCTO, and KoBoToolbox. These tools provide open-source options for off-grid use in public health data collection, management, analysis, and reporting. During the 2018–2020 Ebola epidemic in the North Kivu and Ituri regions of Democratic Republic of Congo, we used these tools to support the DRC Ministère de la Santé RDC and World Health Organization in their efforts to administer an experimental vaccine (VSV-Zebov-GP) as part of their strategy to control the transmission of infection.Method: New functions were developed to facilitate the use of ODK, Enketo and R in large scale data collection, aggregation, monitoring, and near-real-time analysis during clinical research in health emergencies. We present enhancements to ODK that include a built-in audit-trail, a framework and companion app for biometric registration of ISO/IEC 19794-2 fingerprint templates, enhanced performance features, better scalability for studies featuring millions of data form submissions, increased options for parallelization of research projects, and pipelines for automated management and analysis of data. We also developed novel encryption protocols for enhanced web-form security in Enketo.Results: Against the backdrop of a complex and challenging epidemic response, our enhanced platform of open tools was used to collect and manage data from more than 280,000 eligible study participants who received VSV-Zebov-GP under informed consent. These data were used to determine whether the VSV-Zebov-GP was safe and effective and to guide daily field operations.Conclusions: We present open-source developments that make electronic data management during clinical research and health emergencies more viable and robust. These developments will also enhance and expand the functionality of a diverse range of data collection platforms that are based on the ODK software and standards.
format	article
author	Michael Marks Sham Lal Hannah Brindle Pierre-Stéphane Gsell Matthew MacGregor Callum Stott Martijn van de Rijdt Guillermo Gutiérrez Almazor Suman Golia Conall Watson Abdourahamane Diallo Alhassane Toure Catherine Houlihan Patrick Keating Patrick Keating Hélène Martin Ana-Maria Henao Restrepo Yaw Anokwa Chrissy H. Roberts
author_facet	Michael Marks Sham Lal Hannah Brindle Pierre-Stéphane Gsell Matthew MacGregor Callum Stott Martijn van de Rijdt Guillermo Gutiérrez Almazor Suman Golia Conall Watson Abdourahamane Diallo Alhassane Toure Catherine Houlihan Patrick Keating Patrick Keating Hélène Martin Ana-Maria Henao Restrepo Yaw Anokwa Chrissy H. Roberts
author_sort	Michael Marks
title	Electronic Data Management for Vaccine Trials in Low Resource Settings: Upgrades, Scalability, and Impact of ODK
title_short	Electronic Data Management for Vaccine Trials in Low Resource Settings: Upgrades, Scalability, and Impact of ODK
title_full	Electronic Data Management for Vaccine Trials in Low Resource Settings: Upgrades, Scalability, and Impact of ODK
title_fullStr	Electronic Data Management for Vaccine Trials in Low Resource Settings: Upgrades, Scalability, and Impact of ODK
title_full_unstemmed	Electronic Data Management for Vaccine Trials in Low Resource Settings: Upgrades, Scalability, and Impact of ODK
title_sort	electronic data management for vaccine trials in low resource settings: upgrades, scalability, and impact of odk
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/318cbca4382141ec8ca751f7eedf54df
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Electronic Data Management for Vaccine Trials in Low Resource Settings: Upgrades, Scalability, and Impact of ODK

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