Two variants in the fibulin2 gene are associated with lower systolic blood pressure and decreased risk of hypertension.

Arterial stiffness is an important factor in hypertension. Fibulin 2 is an extracellular matrix scaffold protein involved in arterial stiffness and, hence, the fibulin 2 (FBLN2) gene may be a candidate for hypertension susceptibility. 4 single nucleotide polymorphisms (SNPs) of FBLN2 were evaluated...

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Autores principales:	Joan-Carles Vallvé, Noemí Serra, Guillermo Zalba, Ana Fortuño, Oscar Beloqui, Raimon Ferre, Josep Ribalta, Lluís Masana
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/318f2a96b2874a3698e33f53fdbee6e1
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spelling	oai:doaj.org-article:318f2a96b2874a3698e33f53fdbee6e12021-11-18T07:08:55ZTwo variants in the fibulin2 gene are associated with lower systolic blood pressure and decreased risk of hypertension.1932-620310.1371/journal.pone.0043051https://doaj.org/article/318f2a96b2874a3698e33f53fdbee6e12012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22912785/?tool=EBIhttps://doaj.org/toc/1932-6203Arterial stiffness is an important factor in hypertension. Fibulin 2 is an extracellular matrix scaffold protein involved in arterial stiffness and, hence, the fibulin 2 (FBLN2) gene may be a candidate for hypertension susceptibility. 4 single nucleotide polymorphisms (SNPs) of FBLN2 were evaluated in an association case-control study containing 447 hypertensive patients and 344 normotensive control subjects. The minor allele frequencies of rs3732666 and rs1061376 were significantly lower in hypertensives. The odds ratios (OR) for having the protective G (rs3732666) and T (rs1061376) alleles were 0.75 (95%CI: 0.58 to 0.96) and 0.83 (95%CI: 0.66 to 1.02), respectively. For rs3732666, the OR for hypertension in AG+GG subjects, compared with AA, was 0.71 (95%CI: 0.52 to 0.95). The protective genotype AG+GG was associated with significantly lower systolic blood pressure (SBP) [-3.6 mmHg (P = 0.048)]. There was a significant age interaction with rs3732666; the effect decreasing with increasing age. For rs1061376, TT subjects had an OR for hypertension of 0.53 (95%CI: 0.32 to 0.87) compared with CC subjects, with reduced SBP (-7.91 mmHg; P = 0.008) and diastolic BP (DBP) (-3.69 mmHg; P = 0.015). The presence of a G allele was an independent predictor of intima-media thickness (IMT); G carrier's having lower mean IMT (-0.037 mm, P = 0.027) compared with AA. Our results provide the first evidence for FBLN2 as a new gene associated with hypertension.Joan-Carles VallvéNoemí SerraGuillermo ZalbaAna FortuñoOscar BeloquiRaimon FerreJosep RibaltaLluís MasanaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 8, p e43051 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Joan-Carles Vallvé Noemí Serra Guillermo Zalba Ana Fortuño Oscar Beloqui Raimon Ferre Josep Ribalta Lluís Masana Two variants in the fibulin2 gene are associated with lower systolic blood pressure and decreased risk of hypertension.
description	Arterial stiffness is an important factor in hypertension. Fibulin 2 is an extracellular matrix scaffold protein involved in arterial stiffness and, hence, the fibulin 2 (FBLN2) gene may be a candidate for hypertension susceptibility. 4 single nucleotide polymorphisms (SNPs) of FBLN2 were evaluated in an association case-control study containing 447 hypertensive patients and 344 normotensive control subjects. The minor allele frequencies of rs3732666 and rs1061376 were significantly lower in hypertensives. The odds ratios (OR) for having the protective G (rs3732666) and T (rs1061376) alleles were 0.75 (95%CI: 0.58 to 0.96) and 0.83 (95%CI: 0.66 to 1.02), respectively. For rs3732666, the OR for hypertension in AG+GG subjects, compared with AA, was 0.71 (95%CI: 0.52 to 0.95). The protective genotype AG+GG was associated with significantly lower systolic blood pressure (SBP) [-3.6 mmHg (P = 0.048)]. There was a significant age interaction with rs3732666; the effect decreasing with increasing age. For rs1061376, TT subjects had an OR for hypertension of 0.53 (95%CI: 0.32 to 0.87) compared with CC subjects, with reduced SBP (-7.91 mmHg; P = 0.008) and diastolic BP (DBP) (-3.69 mmHg; P = 0.015). The presence of a G allele was an independent predictor of intima-media thickness (IMT); G carrier's having lower mean IMT (-0.037 mm, P = 0.027) compared with AA. Our results provide the first evidence for FBLN2 as a new gene associated with hypertension.
format	article
author	Joan-Carles Vallvé Noemí Serra Guillermo Zalba Ana Fortuño Oscar Beloqui Raimon Ferre Josep Ribalta Lluís Masana
author_facet	Joan-Carles Vallvé Noemí Serra Guillermo Zalba Ana Fortuño Oscar Beloqui Raimon Ferre Josep Ribalta Lluís Masana
author_sort	Joan-Carles Vallvé
title	Two variants in the fibulin2 gene are associated with lower systolic blood pressure and decreased risk of hypertension.
title_short	Two variants in the fibulin2 gene are associated with lower systolic blood pressure and decreased risk of hypertension.
title_full	Two variants in the fibulin2 gene are associated with lower systolic blood pressure and decreased risk of hypertension.
title_fullStr	Two variants in the fibulin2 gene are associated with lower systolic blood pressure and decreased risk of hypertension.
title_full_unstemmed	Two variants in the fibulin2 gene are associated with lower systolic blood pressure and decreased risk of hypertension.
title_sort	two variants in the fibulin2 gene are associated with lower systolic blood pressure and decreased risk of hypertension.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/318f2a96b2874a3698e33f53fdbee6e1
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Two variants in the fibulin2 gene are associated with lower systolic blood pressure and decreased risk of hypertension.

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