Infection via mosquito bite alters Zika virus tissue tropism and replication kinetics in rhesus macaques

Infection via mosquito bite alters Zika virus tissue tropism and replication kinetics in rhesus macaques

Vector saliva can affect infectivity and pathogenesis of vector-borne viruses, but this hasn’t been studied for Zika virus infection. Here, Dudley et al. show that mosquito-mediated Zika infection of macaques results in altered replication kinetics and greater sequence heterogeneity.

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Detalles Bibliográficos
Autores principales: Dawn M. Dudley, Christina M. Newman, Joseph Lalli, Laurel M. Stewart, Michelle R. Koenig, Andrea M. Weiler, Matthew R. Semler, Gabrielle L. Barry, Katie R. Zarbock, Mariel S. Mohns, Meghan E. Breitbach, Nancy Schultz-Darken, Eric Peterson, Wendy Newton, Emma L. Mohr, Saverio Capuano III, Jorge E. Osorio, Shelby L. O’Connor, David H. O’Connor, Thomas C. Friedrich, Matthew T. Aliota
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/31917530d7414bac87d6c4b747a76d29
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Descripción
Sumario:Vector saliva can affect infectivity and pathogenesis of vector-borne viruses, but this hasn’t been studied for Zika virus infection. Here, Dudley et al. show that mosquito-mediated Zika infection of macaques results in altered replication kinetics and greater sequence heterogeneity.

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