Infection via mosquito bite alters Zika virus tissue tropism and replication kinetics in rhesus macaques

Infection via mosquito bite alters Zika virus tissue tropism and replication kinetics in rhesus macaques

Vector saliva can affect infectivity and pathogenesis of vector-borne viruses, but this hasn’t been studied for Zika virus infection. Here, Dudley et al. show that mosquito-mediated Zika infection of macaques results in altered replication kinetics and greater sequence heterogeneity.

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Autores principales: Dawn M. Dudley, Christina M. Newman, Joseph Lalli, Laurel M. Stewart, Michelle R. Koenig, Andrea M. Weiler, Matthew R. Semler, Gabrielle L. Barry, Katie R. Zarbock, Mariel S. Mohns, Meghan E. Breitbach, Nancy Schultz-Darken, Eric Peterson, Wendy Newton, Emma L. Mohr, Saverio Capuano III, Jorge E. Osorio, Shelby L. O’Connor, David H. O’Connor, Thomas C. Friedrich, Matthew T. Aliota
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/31917530d7414bac87d6c4b747a76d29
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spelling oai:doaj.org-article:31917530d7414bac87d6c4b747a76d292021-12-02T17:06:29ZInfection via mosquito bite alters Zika virus tissue tropism and replication kinetics in rhesus macaques10.1038/s41467-017-02222-82041-1723https://doaj.org/article/31917530d7414bac87d6c4b747a76d292017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02222-8https://doaj.org/toc/2041-1723Vector saliva can affect infectivity and pathogenesis of vector-borne viruses, but this hasn’t been studied for Zika virus infection. Here, Dudley et al. show that mosquito-mediated Zika infection of macaques results in altered replication kinetics and greater sequence heterogeneity.Dawn M. DudleyChristina M. NewmanJoseph LalliLaurel M. StewartMichelle R. KoenigAndrea M. WeilerMatthew R. SemlerGabrielle L. BarryKatie R. ZarbockMariel S. MohnsMeghan E. BreitbachNancy Schultz-DarkenEric PetersonWendy NewtonEmma L. MohrSaverio Capuano IIIJorge E. OsorioShelby L. O’ConnorDavid H. O’ConnorThomas C. FriedrichMatthew T. AliotaNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Dawn M. Dudley
Christina M. Newman
Joseph Lalli
Laurel M. Stewart
Michelle R. Koenig
Andrea M. Weiler
Matthew R. Semler
Gabrielle L. Barry
Katie R. Zarbock
Mariel S. Mohns
Meghan E. Breitbach
Nancy Schultz-Darken
Eric Peterson
Wendy Newton
Emma L. Mohr
Saverio Capuano III
Jorge E. Osorio
Shelby L. O’Connor
David H. O’Connor
Thomas C. Friedrich
Matthew T. Aliota
Infection via mosquito bite alters Zika virus tissue tropism and replication kinetics in rhesus macaques
description Vector saliva can affect infectivity and pathogenesis of vector-borne viruses, but this hasn’t been studied for Zika virus infection. Here, Dudley et al. show that mosquito-mediated Zika infection of macaques results in altered replication kinetics and greater sequence heterogeneity.
format article
author Dawn M. Dudley
Christina M. Newman
Joseph Lalli
Laurel M. Stewart
Michelle R. Koenig
Andrea M. Weiler
Matthew R. Semler
Gabrielle L. Barry
Katie R. Zarbock
Mariel S. Mohns
Meghan E. Breitbach
Nancy Schultz-Darken
Eric Peterson
Wendy Newton
Emma L. Mohr
Saverio Capuano III
Jorge E. Osorio
Shelby L. O’Connor
David H. O’Connor
Thomas C. Friedrich
Matthew T. Aliota
author_facet Dawn M. Dudley
Christina M. Newman
Joseph Lalli
Laurel M. Stewart
Michelle R. Koenig
Andrea M. Weiler
Matthew R. Semler
Gabrielle L. Barry
Katie R. Zarbock
Mariel S. Mohns
Meghan E. Breitbach
Nancy Schultz-Darken
Eric Peterson
Wendy Newton
Emma L. Mohr
Saverio Capuano III
Jorge E. Osorio
Shelby L. O’Connor
David H. O’Connor
Thomas C. Friedrich
Matthew T. Aliota
author_sort Dawn M. Dudley
title Infection via mosquito bite alters Zika virus tissue tropism and replication kinetics in rhesus macaques
title_short Infection via mosquito bite alters Zika virus tissue tropism and replication kinetics in rhesus macaques
title_full Infection via mosquito bite alters Zika virus tissue tropism and replication kinetics in rhesus macaques
title_fullStr Infection via mosquito bite alters Zika virus tissue tropism and replication kinetics in rhesus macaques
title_full_unstemmed Infection via mosquito bite alters Zika virus tissue tropism and replication kinetics in rhesus macaques
title_sort infection via mosquito bite alters zika virus tissue tropism and replication kinetics in rhesus macaques
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/31917530d7414bac87d6c4b747a76d29
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