Genetic variants of CD209 associated with Kawasaki disease susceptibility.

<h4>Background</h4>Kawasaki disease (KD) is a systemic vasculitis with unknown etiology mainly affecting children in Asian countries. Dendritic cell-specific intercellular adhesion molecule-3 grabbing non-integrin (DC-SIGN, CD209) in humans was showed to trigger an anti-inflammatory casc...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ho-Chang Kuo, Ying-Hsien Huang, Shu-Chen Chien, Hong-Ren Yu, Kai-Sheng Hsieh, Yu-Wen Hsu, Wei-Chiao Chang
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/31922cb4731a42cfaaa7254524c05fb0
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:31922cb4731a42cfaaa7254524c05fb0
record_format	dspace
spelling	oai:doaj.org-article:31922cb4731a42cfaaa7254524c05fb02021-11-25T06:03:27ZGenetic variants of CD209 associated with Kawasaki disease susceptibility.1932-620310.1371/journal.pone.0105236https://doaj.org/article/31922cb4731a42cfaaa7254524c05fb02014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25148534/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Kawasaki disease (KD) is a systemic vasculitis with unknown etiology mainly affecting children in Asian countries. Dendritic cell-specific intercellular adhesion molecule-3 grabbing non-integrin (DC-SIGN, CD209) in humans was showed to trigger an anti-inflammatory cascade and associated with KD susceptibility. This study was conducted to investigate the association between genetic polymorphisms of CD209 and the risk KD.<h4>Methods</h4>A total of 948 subjects (381 KD and 567 controls) were recruited. Nine tagging SNPs (rs8112310, rs4804800, rs11465421, rs1544766, rs4804801, rs2287886, rs735239, rs735240, rs4804804) were selected for TaqMan allelic discrimination assay. Clinical phenotypes, coronary artery lesions (CAL) and intravenous immunoglobulin (IVIG) treatment outcomes were collected for analysis.<h4>Results</h4>Significant associations were found between CD209 polymorphisms (rs4804800, rs2287886, rs735240) and the risk of KD. Haplotype analysis for CD209 polymorphisms showed that A/A/G haplotype (P = 0.0002, OR = 1.61) and G/A/G haplotype (P = 0.0365, OR = 1.52) had higher risk of KD as compared with G/G/A haplotype in rs2287886/rs735239/rs735240 pairwise allele analysis. There were no significant association in KD with regards to CAL formation and IVIG treatment responses.<h4>Conclusion</h4>CD209 polymorphisms were responsible for the susceptibility of KD, but not CAL formation and IVIG treatment responsiveness.Ho-Chang KuoYing-Hsien HuangShu-Chen ChienHong-Ren YuKai-Sheng HsiehYu-Wen HsuWei-Chiao ChangPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 8, p e105236 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ho-Chang Kuo Ying-Hsien Huang Shu-Chen Chien Hong-Ren Yu Kai-Sheng Hsieh Yu-Wen Hsu Wei-Chiao Chang Genetic variants of CD209 associated with Kawasaki disease susceptibility.
description	<h4>Background</h4>Kawasaki disease (KD) is a systemic vasculitis with unknown etiology mainly affecting children in Asian countries. Dendritic cell-specific intercellular adhesion molecule-3 grabbing non-integrin (DC-SIGN, CD209) in humans was showed to trigger an anti-inflammatory cascade and associated with KD susceptibility. This study was conducted to investigate the association between genetic polymorphisms of CD209 and the risk KD.<h4>Methods</h4>A total of 948 subjects (381 KD and 567 controls) were recruited. Nine tagging SNPs (rs8112310, rs4804800, rs11465421, rs1544766, rs4804801, rs2287886, rs735239, rs735240, rs4804804) were selected for TaqMan allelic discrimination assay. Clinical phenotypes, coronary artery lesions (CAL) and intravenous immunoglobulin (IVIG) treatment outcomes were collected for analysis.<h4>Results</h4>Significant associations were found between CD209 polymorphisms (rs4804800, rs2287886, rs735240) and the risk of KD. Haplotype analysis for CD209 polymorphisms showed that A/A/G haplotype (P = 0.0002, OR = 1.61) and G/A/G haplotype (P = 0.0365, OR = 1.52) had higher risk of KD as compared with G/G/A haplotype in rs2287886/rs735239/rs735240 pairwise allele analysis. There were no significant association in KD with regards to CAL formation and IVIG treatment responses.<h4>Conclusion</h4>CD209 polymorphisms were responsible for the susceptibility of KD, but not CAL formation and IVIG treatment responsiveness.
format	article
author	Ho-Chang Kuo Ying-Hsien Huang Shu-Chen Chien Hong-Ren Yu Kai-Sheng Hsieh Yu-Wen Hsu Wei-Chiao Chang
author_facet	Ho-Chang Kuo Ying-Hsien Huang Shu-Chen Chien Hong-Ren Yu Kai-Sheng Hsieh Yu-Wen Hsu Wei-Chiao Chang
author_sort	Ho-Chang Kuo
title	Genetic variants of CD209 associated with Kawasaki disease susceptibility.
title_short	Genetic variants of CD209 associated with Kawasaki disease susceptibility.
title_full	Genetic variants of CD209 associated with Kawasaki disease susceptibility.
title_fullStr	Genetic variants of CD209 associated with Kawasaki disease susceptibility.
title_full_unstemmed	Genetic variants of CD209 associated with Kawasaki disease susceptibility.
title_sort	genetic variants of cd209 associated with kawasaki disease susceptibility.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/31922cb4731a42cfaaa7254524c05fb0
work_keys_str_mv	AT hochangkuo geneticvariantsofcd209associatedwithkawasakidiseasesusceptibility AT yinghsienhuang geneticvariantsofcd209associatedwithkawasakidiseasesusceptibility AT shuchenchien geneticvariantsofcd209associatedwithkawasakidiseasesusceptibility AT hongrenyu geneticvariantsofcd209associatedwithkawasakidiseasesusceptibility AT kaishenghsieh geneticvariantsofcd209associatedwithkawasakidiseasesusceptibility AT yuwenhsu geneticvariantsofcd209associatedwithkawasakidiseasesusceptibility AT weichiaochang geneticvariantsofcd209associatedwithkawasakidiseasesusceptibility
_version_	1718414214029115392

Genetic variants of CD209 associated with Kawasaki disease susceptibility.

Ejemplares similares