Pembrolizumab or Bevacizumab Plus Chemotherapy as First-Line Treatment of Advanced Nonsquamous Nonsmall Cell Lung Cancer: A Retrospective Cohort Study

Objective: Pembrolizumab and bevacizumab both have antitumor activity. According to NCCN updated guideline the benefit of pembrolizumab or bevacizumab as a first line in management of advanced nonsmall cell lung cancer (NSCLC) is documented in randomized controlled studies. The study aimed to evalua...

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Autores principales: Jie Zhang PhD, Di Wu PhD, Ziran Zhang PhD, Jieran Long PhD, Guangming Tian PhD, Yang Wang PhD, Xiangjuan Ma PhD, Xiaoling Chen PhD, Jindi Han PhD, Weiheng Hu PhD, Ling Dai PhD, Jun Nie PhD, Jian Fang PhD
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Lenguaje:EN
Publicado: SAGE Publishing 2021
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Acceso en línea:https://doaj.org/article/31934071c47149bf87053edf3807d5a3
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spelling oai:doaj.org-article:31934071c47149bf87053edf3807d5a32021-12-02T01:04:19ZPembrolizumab or Bevacizumab Plus Chemotherapy as First-Line Treatment of Advanced Nonsquamous Nonsmall Cell Lung Cancer: A Retrospective Cohort Study1533-033810.1177/15330338211039676https://doaj.org/article/31934071c47149bf87053edf3807d5a32021-11-01T00:00:00Zhttps://doi.org/10.1177/15330338211039676https://doaj.org/toc/1533-0338Objective: Pembrolizumab and bevacizumab both have antitumor activity. According to NCCN updated guideline the benefit of pembrolizumab or bevacizumab as a first line in management of advanced nonsmall cell lung cancer (NSCLC) is documented in randomized controlled studies. The study aimed to evaluate the response and complications of patients with advanced NSCLC treated with pembrolizumab or bevacizumab plus chemotherapy. Methods: This study was a retrospective cohort study of patients with advanced nonsquamous NSCLC who received cisplatin with pemetrexed combined with pembrolizumab (A group) or bevacizumab (B group) from 07/02/2018 to 07/03/2021 at Peking University Cancer Hospital. Progression-free survival (PFS) was the primary outcome. The secondary outcomes included overall survival (OS), objective response rate (ORR), disease control rate (DCR), duration of response (DoR), and adverse events (AEs). Results: This study included 66 patients, 34 in A group and 32 in B group. There were no differences in median PFS (7.6 vs 9.9 months, P  = .601). There were no differences in median OS (23.1 vs 24.2 months, P  = .782). There were no differences in ORR (57.6 % vs 41.9 % , P  = .211) and DCR (93.9 % vs 100.0 % , P  = .164) between 2 groups. The occurrence of AEs was similar. No new safety signals were observed. Grade 3 to 4 treatment-related AEs occurred in 17 (50.0 % ) patients of A group and in 12 (37.5 % ) of B group ( P  > .05). Conclusion: The addition of pembrolizumab or bevacizumab to pemetrexed plus cisplatin was well tolerated and resulted in a clinically meaningful treatment benefit in advanced nonsquamous NSCLC. When pembrolizumab is not suitable, bevacizumab plus chemotherapy may be an option.Jie Zhang PhDDi Wu PhDZiran Zhang PhDJieran Long PhDGuangming Tian PhDYang Wang PhDXiangjuan Ma PhDXiaoling Chen PhDJindi Han PhDWeiheng Hu PhDLing Dai PhDJun Nie PhDJian Fang PhDSAGE PublishingarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENTechnology in Cancer Research & Treatment, Vol 20 (2021)
institution DOAJ
collection DOAJ
language EN
topic Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
spellingShingle Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Jie Zhang PhD
Di Wu PhD
Ziran Zhang PhD
Jieran Long PhD
Guangming Tian PhD
Yang Wang PhD
Xiangjuan Ma PhD
Xiaoling Chen PhD
Jindi Han PhD
Weiheng Hu PhD
Ling Dai PhD
Jun Nie PhD
Jian Fang PhD
Pembrolizumab or Bevacizumab Plus Chemotherapy as First-Line Treatment of Advanced Nonsquamous Nonsmall Cell Lung Cancer: A Retrospective Cohort Study
description Objective: Pembrolizumab and bevacizumab both have antitumor activity. According to NCCN updated guideline the benefit of pembrolizumab or bevacizumab as a first line in management of advanced nonsmall cell lung cancer (NSCLC) is documented in randomized controlled studies. The study aimed to evaluate the response and complications of patients with advanced NSCLC treated with pembrolizumab or bevacizumab plus chemotherapy. Methods: This study was a retrospective cohort study of patients with advanced nonsquamous NSCLC who received cisplatin with pemetrexed combined with pembrolizumab (A group) or bevacizumab (B group) from 07/02/2018 to 07/03/2021 at Peking University Cancer Hospital. Progression-free survival (PFS) was the primary outcome. The secondary outcomes included overall survival (OS), objective response rate (ORR), disease control rate (DCR), duration of response (DoR), and adverse events (AEs). Results: This study included 66 patients, 34 in A group and 32 in B group. There were no differences in median PFS (7.6 vs 9.9 months, P  = .601). There were no differences in median OS (23.1 vs 24.2 months, P  = .782). There were no differences in ORR (57.6 % vs 41.9 % , P  = .211) and DCR (93.9 % vs 100.0 % , P  = .164) between 2 groups. The occurrence of AEs was similar. No new safety signals were observed. Grade 3 to 4 treatment-related AEs occurred in 17 (50.0 % ) patients of A group and in 12 (37.5 % ) of B group ( P  > .05). Conclusion: The addition of pembrolizumab or bevacizumab to pemetrexed plus cisplatin was well tolerated and resulted in a clinically meaningful treatment benefit in advanced nonsquamous NSCLC. When pembrolizumab is not suitable, bevacizumab plus chemotherapy may be an option.
format article
author Jie Zhang PhD
Di Wu PhD
Ziran Zhang PhD
Jieran Long PhD
Guangming Tian PhD
Yang Wang PhD
Xiangjuan Ma PhD
Xiaoling Chen PhD
Jindi Han PhD
Weiheng Hu PhD
Ling Dai PhD
Jun Nie PhD
Jian Fang PhD
author_facet Jie Zhang PhD
Di Wu PhD
Ziran Zhang PhD
Jieran Long PhD
Guangming Tian PhD
Yang Wang PhD
Xiangjuan Ma PhD
Xiaoling Chen PhD
Jindi Han PhD
Weiheng Hu PhD
Ling Dai PhD
Jun Nie PhD
Jian Fang PhD
author_sort Jie Zhang PhD
title Pembrolizumab or Bevacizumab Plus Chemotherapy as First-Line Treatment of Advanced Nonsquamous Nonsmall Cell Lung Cancer: A Retrospective Cohort Study
title_short Pembrolizumab or Bevacizumab Plus Chemotherapy as First-Line Treatment of Advanced Nonsquamous Nonsmall Cell Lung Cancer: A Retrospective Cohort Study
title_full Pembrolizumab or Bevacizumab Plus Chemotherapy as First-Line Treatment of Advanced Nonsquamous Nonsmall Cell Lung Cancer: A Retrospective Cohort Study
title_fullStr Pembrolizumab or Bevacizumab Plus Chemotherapy as First-Line Treatment of Advanced Nonsquamous Nonsmall Cell Lung Cancer: A Retrospective Cohort Study
title_full_unstemmed Pembrolizumab or Bevacizumab Plus Chemotherapy as First-Line Treatment of Advanced Nonsquamous Nonsmall Cell Lung Cancer: A Retrospective Cohort Study
title_sort pembrolizumab or bevacizumab plus chemotherapy as first-line treatment of advanced nonsquamous nonsmall cell lung cancer: a retrospective cohort study
publisher SAGE Publishing
publishDate 2021
url https://doaj.org/article/31934071c47149bf87053edf3807d5a3
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