Exposure to Violence Accelerates Epigenetic Aging in Children

Abstract Epigenetic processes, including DNA methylation, change reliably with age across the lifespan, such that DNA methylation can be used as an “epigenetic clock”. This epigenetic clock can be used to predict age and age acceleration, which occurs when methylation-based prediction of age exceeds...

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Autores principales:	Tanja Jovanovic, L. Alexander Vance, Dorthie Cross, Anna K. Knight, Varun Kilaru, Vasiliki Michopoulos, Torsten Klengel, Alicia K. Smith
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3193b43c5ed54e5f9d4618255143291c
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spelling	oai:doaj.org-article:3193b43c5ed54e5f9d4618255143291c2021-12-02T16:08:21ZExposure to Violence Accelerates Epigenetic Aging in Children10.1038/s41598-017-09235-92045-2322https://doaj.org/article/3193b43c5ed54e5f9d4618255143291c2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-09235-9https://doaj.org/toc/2045-2322Abstract Epigenetic processes, including DNA methylation, change reliably with age across the lifespan, such that DNA methylation can be used as an “epigenetic clock”. This epigenetic clock can be used to predict age and age acceleration, which occurs when methylation-based prediction of age exceeds chronological age and has been associated with increased mortality. In the current study we examined epigenetic age acceleration using saliva samples collected from children between ages 6–13 (N = 101). Children’s exposure to neighborhood violence and heart rate during a stressful task were assessed. Age acceleration was associated with children’s direct experience of violence (p = 0.004) and with decreased heart rate (p = 0.002). Children who were predicted to be older than their chronological age had twice as much violence exposure as other children and their heart rate was similar to that of adults. The results remained significant after controlling for demographic variables, such as sex, income and education. This is the first study to show the effects of direct violence exposure on epigenetic aging in children using salivary DNA. Although longitudinal studies are needed to determine whether accelerated epigenetic aging leads to adverse health outcomes later in life, these data point to DNA methylation during childhood as a putative biological mechanism.Tanja JovanovicL. Alexander VanceDorthie CrossAnna K. KnightVarun KilaruVasiliki MichopoulosTorsten KlengelAlicia K. SmithNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tanja Jovanovic L. Alexander Vance Dorthie Cross Anna K. Knight Varun Kilaru Vasiliki Michopoulos Torsten Klengel Alicia K. Smith Exposure to Violence Accelerates Epigenetic Aging in Children
description	Abstract Epigenetic processes, including DNA methylation, change reliably with age across the lifespan, such that DNA methylation can be used as an “epigenetic clock”. This epigenetic clock can be used to predict age and age acceleration, which occurs when methylation-based prediction of age exceeds chronological age and has been associated with increased mortality. In the current study we examined epigenetic age acceleration using saliva samples collected from children between ages 6–13 (N = 101). Children’s exposure to neighborhood violence and heart rate during a stressful task were assessed. Age acceleration was associated with children’s direct experience of violence (p = 0.004) and with decreased heart rate (p = 0.002). Children who were predicted to be older than their chronological age had twice as much violence exposure as other children and their heart rate was similar to that of adults. The results remained significant after controlling for demographic variables, such as sex, income and education. This is the first study to show the effects of direct violence exposure on epigenetic aging in children using salivary DNA. Although longitudinal studies are needed to determine whether accelerated epigenetic aging leads to adverse health outcomes later in life, these data point to DNA methylation during childhood as a putative biological mechanism.
format	article
author	Tanja Jovanovic L. Alexander Vance Dorthie Cross Anna K. Knight Varun Kilaru Vasiliki Michopoulos Torsten Klengel Alicia K. Smith
author_facet	Tanja Jovanovic L. Alexander Vance Dorthie Cross Anna K. Knight Varun Kilaru Vasiliki Michopoulos Torsten Klengel Alicia K. Smith
author_sort	Tanja Jovanovic
title	Exposure to Violence Accelerates Epigenetic Aging in Children
title_short	Exposure to Violence Accelerates Epigenetic Aging in Children
title_full	Exposure to Violence Accelerates Epigenetic Aging in Children
title_fullStr	Exposure to Violence Accelerates Epigenetic Aging in Children
title_full_unstemmed	Exposure to Violence Accelerates Epigenetic Aging in Children
title_sort	exposure to violence accelerates epigenetic aging in children
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/3193b43c5ed54e5f9d4618255143291c
work_keys_str_mv	AT tanjajovanovic exposuretoviolenceacceleratesepigeneticaginginchildren AT lalexandervance exposuretoviolenceacceleratesepigeneticaginginchildren AT dorthiecross exposuretoviolenceacceleratesepigeneticaginginchildren AT annakknight exposuretoviolenceacceleratesepigeneticaginginchildren AT varunkilaru exposuretoviolenceacceleratesepigeneticaginginchildren AT vasilikimichopoulos exposuretoviolenceacceleratesepigeneticaginginchildren AT torstenklengel exposuretoviolenceacceleratesepigeneticaginginchildren AT aliciaksmith exposuretoviolenceacceleratesepigeneticaginginchildren
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Exposure to Violence Accelerates Epigenetic Aging in Children

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