The STIM1-binding site nexus remotely controls Orai1 channel gating

How plasma membrane Orai Ca2+ channels are activated by STIM proteins to activate Ca2+signals is still not fully known. Here the authors show that a nexus region located at the Orai1 C-terminus allows channel gating without a direct interaction of STIM1 with the channel pore.

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Autores principales:	Yandong Zhou, Xiangyu Cai, Natalia A. Loktionova, Xianming Wang, Robert M. Nwokonko, Xizhuo Wang, Youjun Wang, Brad S. Rothberg, Mohamed Trebak, Donald L. Gill
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/319437aa2a59462e85ad73d129f7e2ee
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spelling	oai:doaj.org-article:319437aa2a59462e85ad73d129f7e2ee2021-12-02T14:39:14ZThe STIM1-binding site nexus remotely controls Orai1 channel gating10.1038/ncomms137252041-1723https://doaj.org/article/319437aa2a59462e85ad73d129f7e2ee2016-12-01T00:00:00Zhttps://doi.org/10.1038/ncomms13725https://doaj.org/toc/2041-1723How plasma membrane Orai Ca2+ channels are activated by STIM proteins to activate Ca2+signals is still not fully known. Here the authors show that a nexus region located at the Orai1 C-terminus allows channel gating without a direct interaction of STIM1 with the channel pore.Yandong ZhouXiangyu CaiNatalia A. LoktionovaXianming WangRobert M. NwokonkoXizhuo WangYoujun WangBrad S. RothbergMohamed TrebakDonald L. GillNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yandong Zhou Xiangyu Cai Natalia A. Loktionova Xianming Wang Robert M. Nwokonko Xizhuo Wang Youjun Wang Brad S. Rothberg Mohamed Trebak Donald L. Gill The STIM1-binding site nexus remotely controls Orai1 channel gating
description	How plasma membrane Orai Ca2+ channels are activated by STIM proteins to activate Ca2+signals is still not fully known. Here the authors show that a nexus region located at the Orai1 C-terminus allows channel gating without a direct interaction of STIM1 with the channel pore.
format	article
author	Yandong Zhou Xiangyu Cai Natalia A. Loktionova Xianming Wang Robert M. Nwokonko Xizhuo Wang Youjun Wang Brad S. Rothberg Mohamed Trebak Donald L. Gill
author_facet	Yandong Zhou Xiangyu Cai Natalia A. Loktionova Xianming Wang Robert M. Nwokonko Xizhuo Wang Youjun Wang Brad S. Rothberg Mohamed Trebak Donald L. Gill
author_sort	Yandong Zhou
title	The STIM1-binding site nexus remotely controls Orai1 channel gating
title_short	The STIM1-binding site nexus remotely controls Orai1 channel gating
title_full	The STIM1-binding site nexus remotely controls Orai1 channel gating
title_fullStr	The STIM1-binding site nexus remotely controls Orai1 channel gating
title_full_unstemmed	The STIM1-binding site nexus remotely controls Orai1 channel gating
title_sort	stim1-binding site nexus remotely controls orai1 channel gating
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/319437aa2a59462e85ad73d129f7e2ee
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The STIM1-binding site nexus remotely controls Orai1 channel gating

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